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Nutrients. 2018 Jun 4;10(6). pii: E721. doi: 10.3390/nu10060721.

Vitamin D₃ Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis.

Author information

1
Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. senait.ashenafi.betemariam@ki.se.
2
Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. jolanta.mazurek@gmx.com.
3
Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. anders.rehn@bredband2.com.
4
Department of Surgery, Faculty of Medicine, Black Lion University Hospital and Addis Ababa University, P.O Box: 28287/1000, Addis Ababa, Ethiopia. bedelemma@yahoo.com.
5
Department of Internal Medicine, Faculty of Medicine, Black Lion University Hospital and Addis Ababa University, P.O Box: 28287/1000, Addis Ababa, Ethiopia. getadera@yahoo.com.
6
Department of Internal Medicine, Faculty of Medicine, Black Lion University Hospital and Addis Ababa University, P.O Box: 28287/1000, Addis Ababa, Ethiopia. amsalubekele2016@gmail.com.
7
Department of Radiology, Faculty of Medicine, Black Lion University Hospital and Addis Ababa University, P.O Box: 28287/1000, Addis Ababa, Ethiopia. g_asefa@yahoo.com.
8
Armauer Hansen Research Institute (AHRI), P.O. Box 1005, Addis Ababa, Ethiopia. menberework@gmail.com.
9
Armauer Hansen Research Institute (AHRI), P.O. Box 1005, Addis Ababa, Ethiopia. aseffaa@gmail.com.
10
Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. jan.andersson@ki.se.
11
Department of Medicine, Division of Infectious Diseases, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. jan.andersson@ki.se.
12
Department of Laboratory Medicine (Labmed), Division of Clinical Microbiology, Karolinska Institutet, 141 86 Stockholm, Sweden. peter.bergman@ki.se.
13
Center for Infectious Medicine (CIM), F59, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. susanna.brighenti@ki.se.

Abstract

Low vitamin D (vitD₃) is one of the most common nutritional deficiencies in the world known to be associated with numerous medical conditions including infections such as tuberculosis (TB). In this study, vitD₃ status and its association with the antimicrobial peptide, human cathelicidin (LL-37), was investigated in Ethiopian patients with different clinical forms of TB. Patients with active TB (n = 77) and non-TB controls (n = 78) were enrolled in Ethiopia, while another group of non-TB controls (n = 62) was from Sweden. Active TB included pulmonary TB (n = 32), pleural TB (n = 20), and lymph node TB (n = 25). Concentrations of 25-hydroxyvitamin D₃ (25(OH)D₃) were assessed in plasma, while LL-37 mRNA was measured in peripheral blood and in samples obtained from the site of infection. Median 25(OH)D₃ plasma levels in active TB patients were similar to Ethiopian non-TB controls (38.5 versus 35.0 nmol/L) and vitD₃ deficiency (.

KEYWORDS:

LL-37; antimicrobial; clinical; tuberculosis; vitamin D

PMID:
29867045
PMCID:
PMC6024873
DOI:
10.3390/nu10060721
[Indexed for MEDLINE]
Free PMC Article

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