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Items: 1 to 20 of 137

1.

Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus.

Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E, Alusi G, Hiley C, Ahmed J, Vanhaesebroeck B, Lemoine NR, Wang Y.

Mol Ther. 2020 Feb 28. pii: S1525-0016(20)30126-X. doi: 10.1016/j.ymthe.2020.02.017. [Epub ahead of print]

2.

PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis.

Wu W, Zhou G, Han H, Huang X, Jiang H, Mukai S, Kazlauskas A, Cui J, Matsubara JA, Vanhaesebroeck B, Xia X, Wang J, Lei H.

Diabetes. 2020 Apr;69(4):736-748. doi: 10.2337/db19-0713. Epub 2020 Jan 8.

PMID:
31915155
3.

Cracking the context-specific PI3K signaling code.

Madsen RR, Vanhaesebroeck B.

Sci Signal. 2020 Jan 7;13(613). pii: eaay2940. doi: 10.1126/scisignal.aay2940. Review.

PMID:
31911433
4.

PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias.

Zhabyeyev P, Chen X, Vanhaesebroeck B, Oudit GY.

Channels (Austin). 2019 Dec;13(1):520-532. doi: 10.1080/19336950.2019.1697127.

5.

Class III PI3K Vps34 Controls Thyroid Hormone Production by Regulating Thyroglobulin Iodination, Lysosomal Proteolysis, and Tissue Homeostasis.

Grieco G, Wang T, Delcorte O, Spourquet C, Janssens V, Strickaert A, Gaide Chevronnay HP, Liao XH, Bilanges B, Refetoff S, Vanhaesebroeck B, Maenhaut C, Courtoy PJ, Pierreux CE.

Thyroid. 2020 Jan;30(1):133-146. doi: 10.1089/thy.2019.0182. Epub 2019 Dec 2.

PMID:
31650902
6.

Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.

Vanhaesebroeck B, Bilanges B, Madsen RR, Dale KL, Lau E, Vladimirou E.

Biomolecules. 2019 Aug 1;9(8). pii: E331. doi: 10.3390/biom9080331. Review.

7.

p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.

Martínez-Mármol R, Mohannak N, Qian L, Wang T, Gormal RS, Ruitenberg MJ, Vanhaesebroeck B, Coulson EJ, Meunier FA.

J Neurosci. 2019 Oct 2;39(40):7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019. Epub 2019 Jul 30.

8.

PI3K isoforms in cell signalling and vesicle trafficking.

Bilanges B, Posor Y, Vanhaesebroeck B.

Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534. doi: 10.1038/s41580-019-0129-z. Review.

PMID:
31110302
9.

Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts.

Zhabyeyev P, McLean B, Chen X, Vanhaesebroeck B, Oudit GY.

J Mol Cell Cardiol. 2019 Jul;132:98-109. doi: 10.1016/j.yjmcc.2019.05.008. Epub 2019 May 13.

PMID:
31095940
10.

PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction.

McLean BA, Patel VB, Zhabyeyev P, Chen X, Basu R, Wang F, Shah S, Vanhaesebroeck B, Oudit GY.

J Am Heart Assoc. 2019 May 7;8(9):e010961. doi: 10.1161/JAHA.118.010961.

11.

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.

Madsen RR, Knox RG, Pearce W, Lopez S, Mahler-Araujo B, McGranahan N, Vanhaesebroeck B, Semple RK.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8380-8389. doi: 10.1073/pnas.1821093116. Epub 2019 Apr 4.

12.

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.

Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR.

Am J Transplant. 2019 Jun;19(6):1820-1830. doi: 10.1111/ajt.15305. Epub 2019 Mar 19.

PMID:
30748099
13.

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.

Patel VB, Zhabyeyev P, Chen X, Wang F, Paul M, Fan D, McLean BA, Basu R, Zhang P, Shah S, Dawson JF, Pyle WG, Hazra M, Kassiri Z, Hazra S, Vanhaesebroeck B, McCulloch CA, Oudit GY.

Nat Commun. 2018 Dec 19;9(1):5390. doi: 10.1038/s41467-018-07812-8.

14.

Endothelial and cardiomyocyte PI3Kβ divergently regulate cardiac remodelling in response to ischaemic injury.

Chen X, Zhabyeyev P, Azad AK, Wang W, Minerath RA, DesAulniers J, Grueter CE, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY.

Cardiovasc Res. 2019 Jul 1;115(8):1343-1356. doi: 10.1093/cvr/cvy298.

PMID:
30496354
15.

Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis.

Laurent PA, Hechler B, Solinhac R, Ragab A, Cabou C, Anquetil T, Severin S, Denis CV, Mangin PH, Vanhaesebroeck B, Payrastre B, Gratacap MP.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2041-2053. doi: 10.1161/ATVBAHA.118.311410.

PMID:
30354258
16.

Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.

Grieco G, Janssens V, Gaide Chevronnay HP, N'Kuli F, Van Der Smissen P, Wang T, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ.

Sci Rep. 2018 Sep 20;8(1):14133. doi: 10.1038/s41598-018-32389-z.

17.

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.

Madsen RR, Vanhaesebroeck B, Semple RK.

Trends Mol Med. 2018 Oct;24(10):856-870. doi: 10.1016/j.molmed.2018.08.003. Epub 2018 Sep 6. Review.

18.

Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome.

Semple RK, Vanhaesebroeck B.

Nature. 2018 Jun;558(7711):523-525. doi: 10.1038/d41586-018-05365-w. No abstract available.

PMID:
29941899
19.

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway.

Palam LR, Mali RS, Ramdas B, Srivatsan SN, Visconte V, Tiu RV, Vanhaesebroeck B, Roers A, Gerbaulet A, Xu M, Janga SC, Takemoto CM, Paczesny S, Kapur R.

JCI Insight. 2018 Feb 22;3(4). pii: 94679. doi: 10.1172/jci.insight.94679. eCollection 2018 Feb 22.

20.

Determinants and clinical implications of chromosomal instability in cancer.

Sansregret L, Vanhaesebroeck B, Swanton C.

Nat Rev Clin Oncol. 2018 Mar;15(3):139-150. doi: 10.1038/nrclinonc.2017.198. Epub 2018 Jan 3. Review.

PMID:
29297505

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