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Nanobody Based Dual Specific CARs.

De Munter S, Ingels J, Goetgeluk G, Bonte S, Pille M, Weening K, Kerre T, Abken H, Vandekerckhove B.

Int J Mol Sci. 2018 Jan 30;19(2). pii: E403. doi: 10.3390/ijms19020403.


Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments.

Cauwels A, Van Lint S, Paul F, Garcin G, De Koker S, Van Parys A, Wueest T, Gerlo S, Van der Heyden J, Bordat Y, Catteeuw D, Rogge E, Verhee A, Vandekerckhove B, Kley N, Uzé G, Tavernier J.

Cancer Res. 2018 Jan 15;78(2):463-474. doi: 10.1158/0008-5472.CAN-17-1980. Epub 2017 Nov 29.


The checkpoint for agonist selection precedes conventional selection in human thymus.

Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B.

Sci Immunol. 2017 Feb 24;2(8). pii: eaah4232. doi: 10.1126/sciimmunol.aah4232.


A Murine Intestinal Intraepithelial NKp46-Negative Innate Lymphoid Cell Population Characterized by Group 1 Properties.

Van Acker A, Gronke K, Biswas A, Martens L, Saeys Y, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Plum J, Dunay IR, Diefenbach A, Leclercq G.

Cell Rep. 2017 May 16;19(7):1431-1443. doi: 10.1016/j.celrep.2017.04.068.


A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter.

Lethé B, Snauwaert S, Bricard O, Schröder D, Gomard T, Hames G, Muller C, Lurquin C, Gauthy E, Essaghir A, Vandekerckhove B, Coulie PG.

Immun Inflamm Dis. 2017 Sep;5(3):346-354. doi: 10.1002/iid3.172. Epub 2017 May 15.


Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.

Van Caeneghem Y, De Munter S, Tieppo P, Goetgeluk G, Weening K, Verstichel G, Bonte S, Taghon T, Leclercq G, Kerre T, Debets R, Vermijlen D, Abken H, Vandekerckhove B.

Oncoimmunology. 2017 Jan 19;6(3):e1283460. doi: 10.1080/2162402X.2017.1283460. eCollection 2017.


The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection.

Filtjens J, Coltel N, Cencig S, Taveirne S, Van Ammel E, Van Acker A, Kerre T, Matthys P, Taghon T, Vandekerckhove B, Carlier Y, Truyens C, Leclercq G.

Front Immunol. 2016 Nov 10;7:472. eCollection 2016.


The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.

Van Acker A, Louagie E, Filtjens J, Taveirne S, Van Ammel E, Kerre T, Elewaut D, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

Cancer Immunol Immunother. 2016 Nov;65(11):1365-1375. Epub 2016 Sep 1.


Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

Filtjens J, Keirsse J, Van Ammel E, Taveirne S, Van Acker A, Kerre T, Taghon T, Vandekerckhove B, Plum J, Van Ginderachter JA, Leclercq G.

Sci Rep. 2016 Jul 29;6:30564. doi: 10.1038/srep30564.


Gene Correction of iPSCs from a Wiskott-Aldrich Syndrome Patient Normalizes the Lymphoid Developmental and Functional Defects.

Laskowski TJ, Van Caeneghem Y, Pourebrahim R, Ma C, Ni Z, Garate Z, Crane AM, Li XS, Liao W, Gonzalez-Garay M, Segovia JC, Paschon DE, Rebar EJ, Holmes MC, Kaufman D, Vandekerckhove B, Davis BR.

Stem Cell Reports. 2016 Aug 9;7(2):139-48. doi: 10.1016/j.stemcr.2016.06.003. Epub 2016 Jul 7.


GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.

Van de Walle I, Dolens AC, Durinck K, De Mulder K, Van Loocke W, Damle S, Waegemans E, De Medts J, Velghe I, De Smedt M, Vandekerckhove B, Kerre T, Plum J, Leclercq G, Rothenberg EV, Van Vlierberghe P, Speleman F, Taghon T.

Nat Commun. 2016 Apr 6;7:11171. doi: 10.1038/ncomms11171.


Pluripotent stem cell based gene therapy for hematological diseases.

Vanhee S, Vandekerckhove B.

Crit Rev Oncol Hematol. 2016 Jan;97:238-46. doi: 10.1016/j.critrevonc.2015.08.022. Epub 2015 Sep 14. Review.


Humanized Mice to Study Human T Cell Development.

Bonte S, Snauwaert S, Vanhee S, Dolens AC, Taghon T, Vandekerckhove B, Kerre T.

Methods Mol Biol. 2016;1323:253-72. doi: 10.1007/978-1-4939-2809-5_21.


Notch3 activation is sufficient but not required for inducing human T-lineage specification.

Waegemans E, Van de Walle I, De Medts J, De Smedt M, Kerre T, Vandekerckhove B, Leclercq G, Wang T, Plum J, Taghon T.

J Immunol. 2014 Dec 15;193(12):5997-6004. doi: 10.4049/jimmunol.1400764. Epub 2014 Nov 7.


In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis.

Vanhee S, De Mulder K, Van Caeneghem Y, Verstichel G, Van Roy N, Menten B, Velghe I, Philippé J, De Bleser D, Lambrecht BN, Taghon T, Leclercq G, Kerre T, Vandekerckhove B.

Haematologica. 2015 Feb;100(2):157-66. doi: 10.3324/haematol.2014.112144. Epub 2014 Nov 7.


Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases.

Van Acker A, Filtjens J, Van Welden S, Taveirne S, Van Ammel E, Vanhees M, Devisscher L, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

PLoS One. 2014 Oct 13;9(10):e110015. doi: 10.1371/journal.pone.0110015. eCollection 2014. Erratum in: PLoS One. 2015;10(4):e0124464.


Contribution of the Ly49E natural killer receptor in the immune response to Plasmodium berghei infection and control of hepatic parasite development.

Filtjens J, Foquet L, Taveirne S, Van Ammel E, Vanhees M, Van Acker A, Kerre T, Taghon T, Vandekerckhove B, Plum J, Van den Steen PE, Leclercq G.

PLoS One. 2014 Jan 30;9(1):e87463. doi: 10.1371/journal.pone.0087463. eCollection 2014.


Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.

Van de Walle I, Waegemans E, De Medts J, De Smet G, De Smedt M, Snauwaert S, Vandekerckhove B, Kerre T, Leclercq G, Plum J, Gridley T, Wang T, Koch U, Radtke F, Taghon T.

J Exp Med. 2013 Apr 8;210(4):683-97. doi: 10.1084/jem.20121798. Epub 2013 Mar 25.


Can immunotherapy specifically target acute myeloid leukemic stem cells?

Snauwaert S, Vandekerckhove B, Kerre T.

Oncoimmunology. 2013 Feb 1;2(2):e22943.


Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.

Filtjens J, Taveirne S, Van Acker A, Van Ammel E, Vanhees M, Kerre T, Taghon T, Vandekerckhove B, Plum J, Leclercq G.

J Leukoc Biol. 2013 May;93(5):699-711. doi: 10.1189/jlb.0812378. Epub 2013 Mar 8.


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