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Items: 1 to 20 of 68

1.

Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells.

Rolle F, Bincoletto V, Gazzano E, Rolando B, Lollo G, Stella B, Riganti C, Arpicco S.

Int J Pharm. 2020 Mar 3;580:119191. doi: 10.1016/j.ijpharm.2020.119191. [Epub ahead of print]

PMID:
32142738
2.

Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells.

Fathy Abd-Ellatef GE, Gazzano E, Chirio D, Hamed AR, Belisario DC, Zuddas C, Peira E, Rolando B, Kopecka J, Assem Said Marie M, Sapino S, Ramadan Fahmy S, Gallarate M, Abdel-Hamid AZ, Riganti C.

Pharmaceutics. 2020 Jan 24;12(2). pii: E96. doi: 10.3390/pharmaceutics12020096.

3.

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide.

Sodano F, Cavanagh RJ, Pearce AK, Lazzarato L, Rolando B, Fraix A, Abelha TF, Vasey CE, Alexander C, Taresco V, Sortino S.

Biomater Sci. 2020 Mar 7;8(5):1329-1344. doi: 10.1039/c9bm01644a. Epub 2020 Jan 8.

PMID:
31912808
4.

Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug.

Sodano F, Lazzarato L, Rolando B, Spyrakis F, De Caro C, Magliocca S, Marabello D, Chegaev K, Gazzano E, Riganti C, Calignano A, Russo R, Rimoli MG.

Mol Pharm. 2019 Oct 7;16(10):4181-4189. doi: 10.1021/acs.molpharmaceut.9b00508. Epub 2019 Sep 12.

PMID:
31465230
5.

Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells.

Salaroglio IC, Abate C, Rolando B, Battaglia L, Gazzano E, Colombino E, Costamagna C, Annovazzi L, Mellai M, Berardi F, Capucchio MT, Schiffer D, Riganti C.

Mol Pharm. 2019 Aug 5;16(8):3361-3373. doi: 10.1021/acs.molpharmaceut.9b00018. Epub 2019 Jul 2.

PMID:
31265310
6.

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.

Giraudo A, Krall J, Bavo F, Nielsen B, Kongstad KT, Rolando B, De Blasio R, Gloriam DE, Löffler R, Thiesen L, Harpsøe K, Frydenvang K, Boschi D, Wellendorph P, Lolli ML, Jensen AA, Frølund B.

J Med Chem. 2019 Jun 27;62(12):5797-5809. doi: 10.1021/acs.jmedchem.9b00026. Epub 2019 Jun 5.

PMID:
31117514
7.

Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae.

Parisi C, Failla M, Fraix A, Rolando B, Gianquinto E, Spyrakis F, Gazzano E, Riganti C, Lazzarato L, Fruttero R, Gasco A, Sortino S.

Chemistry. 2019 Aug 22;25(47):11080-11084. doi: 10.1002/chem.201902062. Epub 2019 Jul 4.

PMID:
31074543
8.

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.

Gazzano E, Buondonno I, Marengo A, Rolando B, Chegaev K, Kopecka J, Saponara S, Sorge M, Hattinger CM, Gasco A, Fruttero R, Brancaccio M, Serra M, Stella B, Fattal E, Arpicco S, Riganti C.

Cancer Lett. 2019 Aug 1;456:29-39. doi: 10.1016/j.canlet.2019.04.029. Epub 2019 Apr 29.

9.

Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.

Lolli ML, Carnovale IM, Pippione AC, Wahlgren WY, Bonanni D, Marini E, Zonari D, Gallicchio M, Boscaro V, Goyal P, Friemann R, Rolando B, Bagnati R, Adinolfi S, Oliaro-Bosso S, Boschi D.

ACS Med Chem Lett. 2019 Jan 28;10(4):437-443. doi: 10.1021/acsmedchemlett.8b00484. eCollection 2019 Apr 11.

PMID:
30996776
10.

Correction to "Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance".

Chegaev K, Fraix A, Gazzano E, Abd-Ellatef GEF, Blangetti M, Rolando B, Conoci S, Riganti C, Fruttero R, Gasco A, Sortino S.

ACS Med Chem Lett. 2019 Feb 28;10(3):393. doi: 10.1021/acsmedchemlett.9b00048. eCollection 2019 Mar 14.

11.

Correction to Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.

Sainas S, Pippione AC, Lupino E, Giorgis M, Circosta P, Gaidano V, Goyal P, Bonanni D, Rolando B, Cignetti A, Ducime A, Andersson M, Järvå M, Friemann R, Piccinini M, Ramondetti C, Buccinnà B, Al-Karadaghi S, Boschi D, Saglio G, Lolli ML.

J Med Chem. 2019 Feb 14;62(3):1696. doi: 10.1021/acs.jmedchem.9b00057. Epub 2019 Jan 29. No abstract available.

PMID:
30694669
12.

A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.

Parisi C, Failla M, Fraix A, Rescifina A, Rolando B, Lazzarato L, Cardile V, Graziano ACE, Fruttero R, Gasco A, Sortino S.

Bioorg Chem. 2019 Apr;85:18-22. doi: 10.1016/j.bioorg.2018.12.027. Epub 2018 Dec 20.

PMID:
30599409
13.

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells.

Riganti C, Contino M, Guglielmo S, Perrone MG, Salaroglio IC, Milosevic V, Giampietro R, Leonetti F, Rolando B, Lazzarato L, Colabufo NA, Fruttero R.

J Med Chem. 2019 Jan 24;62(2):974-986. doi: 10.1021/acs.jmedchem.8b01655. Epub 2019 Jan 9.

PMID:
30584838
14.

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.

Pippione AC, Sainas S, Goyal P, Fritzson I, Cassiano GC, Giraudo A, Giorgis M, Tavella TA, Bagnati R, Rolando B, Caing-Carlsson R, Costa FTM, Andrade CH, Al-Karadaghi S, Boschi D, Friemann R, Lolli ML.

Eur J Med Chem. 2019 Feb 1;163:266-280. doi: 10.1016/j.ejmech.2018.11.044. Epub 2018 Nov 22.

PMID:
30529545
15.

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma.

Buondonno I, Gazzano E, Tavanti E, Chegaev K, Kopecka J, Fanelli M, Rolando B, Fruttero R, Gasco A, Hattinger C, Serra M, Riganti C.

Cell Mol Life Sci. 2019 Feb;76(3):609-625. doi: 10.1007/s00018-018-2967-9. Epub 2018 Nov 14.

PMID:
30430199
16.

Anti-Pseudomonas activity of 3-nitro-4-phenylfuroxan.

Orlandi VT, Bolognese F, Rolando B, Guglielmo S, Lazzarato L, Fruttero R.

Microbiology. 2018 Dec;164(12):1557-1566. doi: 10.1099/mic.0.000730. Epub 2018 Oct 9.

17.

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site.

Giraudo A, Krall J, Nielsen B, Sørensen TE, Kongstad KT, Rolando B, Boschi D, Frølund B, Lolli ML.

Eur J Med Chem. 2018 Oct 5;158:311-321. doi: 10.1016/j.ejmech.2018.08.094. Epub 2018 Sep 5.

PMID:
30223119
18.
19.

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands.

Contino M, Guglielmo S, Perrone MG, Giampietro R, Rolando B, Carrieri A, Zaccaria D, Chegaev K, Borio V, Riganti C, Zabielska-Koczywąs K, Colabufo NA, Fruttero R.

Medchemcomm. 2018 Apr 3;9(5):862-869. doi: 10.1039/c8md00075a. eCollection 2018 May 1.

20.

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.

Sainas S, Pippione AC, Lupino E, Giorgis M, Circosta P, Gaidano V, Goyal P, Bonanni D, Rolando B, Cignetti A, Ducime A, Andersson M, Järvå M, Friemann R, Piccinini M, Ramondetti C, Buccinnà B, Al-Karadaghi S, Boschi D, Saglio G, Lolli ML.

J Med Chem. 2018 Jul 26;61(14):6034-6055. doi: 10.1021/acs.jmedchem.8b00373. Epub 2018 Jul 9. Erratum in: J Med Chem. 2019 Feb 14;62(3):1696.

PMID:
29939742

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