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Items: 1 to 20 of 42

1.

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold.

Rotondi G, Guglielmi P, Carradori S, Secci D, De Monte C, De Filippis B, Maccallini C, Amoroso R, Cirilli R, Akdemir A, Angeli A, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1400-1413. doi: 10.1080/14756366.2019.1651315.

2.

Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Laghezza A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Tortorella P, Veschi S, Loiodice F, Cama A, Amoroso R.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2302-2306. doi: 10.1016/j.bmcl.2019.06.020. Epub 2019 Jun 18.

PMID:
31272790
3.

PPAR Ligands Containing Stilbene Scaffold.

Fantacuzzi M, De Filippis B, Amoroso R, Giampietro L.

Mini Rev Med Chem. 2019 Jun 2. doi: 10.2174/1389557519666190603085026. [Epub ahead of print]

PMID:
31161987
4.

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Ammazzalorso A, Carradori S, Angeli A, Akdemir A, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1051-1061. doi: 10.1080/14756366.2019.1611801.

5.

Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.

Giampietro L, Laghezza A, Cerchia C, Florio R, Recinella L, Capone F, Ammazzalorso A, Bruno I, De Filippis B, Fantacuzzi M, Ferrante C, Maccallini C, Tortorella P, Verginelli F, Brunetti L, Cama A, Amoroso R, Loiodice F, Lavecchia A.

ACS Med Chem Lett. 2019 Feb 25;10(4):545-551. doi: 10.1021/acsmedchemlett.8b00574. eCollection 2019 Apr 11.

PMID:
30996794
6.

Development of Fibrates as Important Scaffolds in Medicinal Chemistry.

Giampietro L, Ammazzalorso A, Amoroso R, De Filippis B.

ChemMedChem. 2019 Jun 5;14(11):1051-1066. doi: 10.1002/cmdc.201900128. Epub 2019 May 7. Review.

PMID:
30957432
7.

PPAR-γ agonist GL516 reduces oxidative stress and apoptosis occurrence in a rat astrocyte cell line.

Giampietro L, Gallorini M, De Filippis B, Amoroso R, Cataldi A, di Giacomo V.

Neurochem Int. 2019 Jun;126:239-245. doi: 10.1016/j.neuint.2019.03.021. Epub 2019 Apr 1.

PMID:
30946848
8.

Stilbene derivatives as new perspective in antifungal medicinal chemistry.

De Filippis B, Ammazzalorso A, Amoroso R, Giampietro L.

Drug Dev Res. 2019 May;80(3):285-293. doi: 10.1002/ddr.21525. Epub 2019 Feb 20.

PMID:
30790326
9.

The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro.

Gallorini M, Maccallini C, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Cataldi A, Amoroso R.

Int J Mol Sci. 2019 Jan 24;20(3). pii: E495. doi: 10.3390/ijms20030495.

10.

Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking.

Giancristofaro A, Barbosa AJM, Ammazzalorso A, Amoia P, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

Medchemcomm. 2018 Jul 4;9(10):1630-1638. doi: 10.1039/c8md00272j. eCollection 2018 Oct 1.

11.

Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.

Maccallini C, Di Matteo M, Gallorini M, Montagnani M, Graziani V, Ammazzalorso A, Amoia P, De Filippis B, Di Silvestre S, Fantacuzzi M, Giampietro L, Potenza MA, Re N, Pandolfi A, Cataldi A, Amoroso R.

Eur J Med Chem. 2018 May 25;152:53-64. doi: 10.1016/j.ejmech.2018.04.027. Epub 2018 Apr 13.

PMID:
29689474
12.

N-acylsulfonamides: Synthetic routes and biological potential in medicinal chemistry.

Ammazzalorso A, De Filippis B, Giampietro L, Amoroso R.

Chem Biol Drug Des. 2017 Dec;90(6):1094-1105. doi: 10.1111/cbdd.13043. Epub 2017 Jul 11. Review.

PMID:
28632928
13.

Cytotoxic effect of a family of peroxisome proliferator-activated receptor antagonists in colorectal and pancreatic cancer cell lines.

Ammazzalorso A, De Lellis L, Florio R, Bruno I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Perconti S, Verginelli F, Cama A, Amoroso R.

Chem Biol Drug Des. 2017 Nov;90(5):1029-1035. doi: 10.1111/cbdd.13026. Epub 2017 Jul 19.

PMID:
28544586
14.

Anticancer Activity of Stilbene-Based Derivatives.

De Filippis B, Ammazzalorso A, Fantacuzzi M, Giampietro L, Maccallini C, Amoroso R.

ChemMedChem. 2017 Apr 20;12(8):558-570. doi: 10.1002/cmdc.201700045. Epub 2017 Mar 28. Review.

PMID:
28266812
15.

Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies.

Ammazzalorso A, De Filippis B, Campestre C, Laghezza A, Marrone A, Amoroso R, Tortorella P, Agamennone M.

Int J Mol Sci. 2016 Oct 22;17(10). pii: E1768.

16.

Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases.

Maccallini C, Di Matteo M, Vullo D, Ammazzalorso A, Carradori S, De Filippis B, Fantacuzzi M, Giampietro L, Pandolfi A, Supuran CT, Amoroso R.

ChemMedChem. 2016 Aug 19;11(16):1695-9. doi: 10.1002/cmdc.201600204. Epub 2016 Jul 5.

PMID:
27377568
17.

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.

Di Matteo M, Ammazzalorso A, Andreoli F, Caffa I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Nencioni A, Parenti MD, Soncini D, Del Rio A, Amoroso R.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3192-3194. doi: 10.1016/j.bmcl.2016.04.078. Epub 2016 Apr 28.

PMID:
27161804
18.

Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists.

Ammazzalorso A, Carrieri A, Verginelli F, Bruno I, Carbonara G, D'Angelo A, De Filippis B, Fantacuzzi M, Florio R, Fracchiolla G, Giampietro L, Giancristofaro A, Maccallini C, Cama A, Amoroso R.

Eur J Med Chem. 2016 May 23;114:191-200. doi: 10.1016/j.ejmech.2016.02.064. Epub 2016 Feb 27.

PMID:
26974385
19.

Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC.

Fantacuzzi M, Maccallini C, Di Matteo M, Ammazzalorso A, Bruno I, De Filippis B, Giampietro L, Mollica A, Amoroso R.

J Pharm Biomed Anal. 2016 Feb 20;120:419-24. doi: 10.1016/j.jpba.2015.11.045. Epub 2015 Dec 2.

PMID:
26689740
20.

Synthesis of Naphthyl-, Quinolin- and Anthracenyl Analogues of Clofibric Acid as PPARα Agonists.

Giampietro L, Ammazzalorso A, Bruno I, Carradori S, De Filippis B, Fantacuzzi M, Giancristofaro A, Maccallini C, Amoroso R.

Chem Biol Drug Des. 2016 Mar;87(3):467-71. doi: 10.1111/cbdd.12677. Epub 2015 Nov 20.

PMID:
26502898

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