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J Cell Physiol. 2019 Aug;234(10):18111-18122. doi: 10.1002/jcp.28443. Epub 2019 Mar 7.

Prognostic significance of X-linked inhibitor of apoptosis protein in solid tumors: A systematic review and meta-analysis.

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Department of Clinical Laboratory, Jilin University China-Japan Union Hospital, Changchun, Jilin, China.
Department of Stomatology, Jilin University School Infirmary, Changchun, Jilin, China.
Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, China.


X-linked inhibitor of apoptosis protein (XIAP) is aberrantly expressed in solid tumors. Considering conflicting data, we conducted this meta-analysis to investigate its prognostic role. Electronic databases were searched to collect studies about associations between XIAP expressions and survival outcomes. Hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI) were utilized as effect size estimates. A total of 3,794 patients from 21 published studies were included. The results revealed that high XIAP expressions correlated with age (OR = 2.02; 95% CI, 1.07-3.84), lymph node metastasis (OR = 1.69; 95% CI, 1.02-2.77), histological grade (OR = 2.04; 95% CI, 1.01-4.11), and tumor stage (OR = 2.18; 95% CI, 1.20-3.96). The combined HR revealed that high XIAP expressions associated with poor overall survival (OS) (HR = 1.60; 95% CI, 1.22-2.10). Our study suggested high XIAP expressions may be indicative of poor prognosis in solid tumors.


X-linked inhibitor of apoptosis protein (XIAP); apoptosis; meta-analysis; prognosis; solid tumor


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