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HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells.

Causse SZ, Marcion G, Chanteloup G, Uyanik B, Boudesco C, Grigorash BB, Douhard R, Dias AMM, Dumetier B, Dondaine L, Gozzi GJ, Moussay E, Paggetti J, Mirjolet C, de Thonel A, Dubrez L, Demidov ON, Gobbo J, Garrido C.

Oncogene. 2019 Apr;38(15):2767-2777. doi: 10.1038/s41388-018-0616-2. Epub 2018 Dec 12.


HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chrétien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A.

Nat Commun. 2018 Apr 12;9(1):1431. doi: 10.1038/s41467-018-03627-9.


Alcohol exposure promotes DNA methyltransferase DNMT3A upregulation through reactive oxygen species-dependent mechanisms.

Miozzo F, Arnould H, de Thonel A, Schang AL, Sabéran-Djoneidi D, Baudry A, Schneider B, Mezger V.

Cell Stress Chaperones. 2018 Jan;23(1):115-126. doi: 10.1007/s12192-017-0829-2. Epub 2017 Jul 15.


Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer.

Gobbo J, Marcion G, Cordonnier M, Dias AMM, Pernet N, Hammann A, Richaud S, Mjahed H, Isambert N, Clausse V, Rébé C, Bertaut A, Goussot V, Lirussi F, Ghiringhelli F, de Thonel A, Fumoleau P, Seigneuric R, Garrido C.

J Natl Cancer Inst. 2015 Nov 22;108(3). doi: 10.1093/jnci/djv330. Print 2016 Mar.


HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms.

Sevin M, Girodon F, Garrido C, de Thonel A.

Mediators Inflamm. 2015;2015:970242. doi: 10.1155/2015/970242. Epub 2015 Oct 15. Review.


Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome.

El Fatimy R, Miozzo F, Le Mouël A, Abane R, Schwendimann L, Sabéran-Djoneidi D, de Thonel A, Massaoudi I, Paslaru L, Hashimoto-Torii K, Christians E, Rakic P, Gressens P, Mezger V.

EMBO Mol Med. 2014 Aug;6(8):1043-61. doi: 10.15252/emmm.201303311.


Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.

Collura A, Lagrange A, Svrcek M, Marisa L, Buhard O, Guilloux A, Wanherdrick K, Dorard C, Taieb A, Saget A, Loh M, Soong R, Zeps N, Platell C, Mews A, Iacopetta B, De Thonel A, Seigneuric R, Marcion G, Chapusot C, Lepage C, Bouvier AM, Gaub MP, Milano G, Selves J, Senet P, Delarue P, Arzouk H, Lacoste C, Coquelle A, Bengrine-Lefèvre L, Tournigand C, Lefèvre JH, Parc Y, Biard DS, Fléjou JF, Garrido C, Duval A.

Gastroenterology. 2014 Feb;146(2):401-11.e1.


Transcriptional regulation of small HSP-HSF1 and beyond.

de Thonel A, Le Mouël A, Mezger V.

Int J Biochem Cell Biol. 2012 Oct;44(10):1593-612. doi: 10.1016/j.biocel.2012.06.012. Epub 2012 Jun 29. Review.


Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Frisan E, Vandekerckhove J, de Thonel A, Pierre-Eugène C, Sternberg A, Arlet JB, Floquet C, Gyan E, Kosmider O, Dreyfus F, Gabet AS, Courtois G, Vyas P, Ribeil JA, Zermati Y, Lacombe C, Mayeux P, Solary E, Garrido C, Hermine O, Fontenay M.

Blood. 2012 Feb 9;119(6):1532-42. doi: 10.1182/blood-2011-03-343475. Epub 2011 Dec 12.


Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.

Dorard C, de Thonel A, Collura A, Marisa L, Svrcek M, Lagrange A, Jego G, Wanherdrick K, Joly AL, Buhard O, Gobbo J, Penard-Lacronique V, Zouali H, Tubacher E, Kirzin S, Selves J, Milano G, Etienne-Grimaldi MC, Bengrine-Lefèvre L, Louvet C, Tournigand C, Lefèvre JH, Parc Y, Tiret E, Fléjou JF, Gaub MP, Garrido C, Duval A.

Nat Med. 2011 Sep 25;17(10):1283-9. doi: 10.1038/nm.2457.


Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy.

Rérole AL, Gobbo J, De Thonel A, Schmitt E, Pais de Barros JP, Hammann A, Lanneau D, Fourmaux E, Demidov ON, Micheau O, Lagrost L, Colas P, Kroemer G, Garrido C.

Cancer Res. 2011 Jan 15;71(2):484-95. doi: 10.1158/0008-5472.CAN-10-1443. Epub 2011 Jan 11. Erratum in: Cancer Res. 2015 Mar 1;75(5):902. Deminov, Oleg [corrected to Demidov, Oleg N].


Implication of heat shock factors in tumorigenesis: therapeutical potential.

De Thonel A, Mezger V, Garrido C.

Cancers (Basel). 2011 Mar 7;3(1):1158-81. doi: 10.3390/cancers3011158.


HSP27 controls GATA-1 protein level during erythroid cell differentiation.

de Thonel A, Vandekerckhove J, Lanneau D, Selvakumar S, Courtois G, Hazoume A, Brunet M, Maurel S, Hammann A, Ribeil JA, Zermati Y, Gabet AS, Boyes J, Solary E, Hermine O, Garrido C.

Blood. 2010 Jul 8;116(1):85-96. doi: 10.1182/blood-2009-09-241778. Epub 2010 Apr 21.


Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis.

de Thonel A, Ferraris SE, Pallari HM, Imanishi SY, Kochin V, Hosokawa T, Hisanaga S, Sahlgren C, Eriksson JE.

Mol Biol Cell. 2010 Apr 15;21(8):1423-34. doi: 10.1091/mbc.E09-10-0847. Epub 2010 Mar 3.


Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, Boireau W, Rouleau A, Simon B, Lanneau D, De Thonel A, Multhoff G, Hamman A, Martin F, Chauffert B, Solary E, Zitvogel L, Garrido C, Ryffel B, Borg C, Apetoh L, Rébé C, Ghiringhelli F.

J Clin Invest. 2010 Feb;120(2):457-71. doi: 10.1172/JCI40483. Epub 2010 Jan 19.


Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.

Didelot C, Lanneau D, Brunet M, Joly AL, De Thonel A, Chiosis G, Garrido C.

Curr Med Chem. 2007;14(27):2839-47. Review.


Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by microLC-ESI-Q-TOF MS/MS.

Imanishi SY, Kochin V, Ferraris SE, de Thonel A, Pallari HM, Corthals GL, Eriksson JE.

Mol Cell Proteomics. 2007 Aug;6(8):1380-91. Epub 2007 May 17.


Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.

Guilloton F, Jean C, de Thonel A, Laurent G, Quillet-Mary A.

Cell Signal. 2007 Jun;19(6):1132-40. Epub 2007 Jan 3.


Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27.

Lanneau D, de Thonel A, Maurel S, Didelot C, Garrido C.

Prion. 2007 Jan-Mar;1(1):53-60. Epub 2007 Jan 24. Review.


Binding and phosphorylation of par-4 by akt is essential for cancer cell survival.

Goswami A, Burikhanov R, de Thonel A, Fujita N, Goswami M, Zhao Y, Eriksson JE, Tsuruo T, Rangnekar VM.

Mol Cell. 2005 Oct 7;20(1):33-44.

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