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Items: 1 to 20 of 35

1.

CMG2 Expression Is an Independent Prognostic Factor for Soft Tissue Sarcoma Patients.

Greither T, Wedler A, Rot S, Keßler J, Kehlen A, Holzhausen HJ, Bache M, Würl P, Taubert H, Kappler M.

Int J Mol Sci. 2017 Dec 7;18(12). pii: E2648. doi: 10.3390/ijms18122648.

2.

N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity.

Kehlen A, Haegele M, Böhme L, Cynis H, Hoffmann T, Demuth HU.

Biosci Rep. 2017 Aug 23;37(4). pii: BSR20170712. doi: 10.1042/BSR20170712. Print 2017 Aug 31.

3.

Differences in the frequencies of HLA-class I and II alleles between German patients with renal cell carcinoma and healthy controls.

Goebel S, Kehlen A, Bluemke K, Altermann W, Schlaf G, Fischer K, Fornara P, Wullich B, Wach S, Taubert H.

Cancer Immunol Immunother. 2017 May;66(5):565-571. doi: 10.1007/s00262-017-1957-3. Epub 2017 Feb 9.

PMID:
28184970
4.

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.

Hellvard A, Zeitlmann L, Heiser U, Kehlen A, Niestroj A, Demuth HU, Koziel J, Delaleu N, Jan Potempa, Mydel P.

Sci Rep. 2016 Aug 11;6:31441. doi: 10.1038/srep31441.

5.

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S.

Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192.

PMID:
26351917
6.

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.

Hartlage-Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jäger C, Kleinschmidt M, Cynis H, Kehlen A, Arendt T, Demuth HU, Rossner S.

Acta Neuropathol. 2015 Apr;129(4):565-83. doi: 10.1007/s00401-015-1395-2. Epub 2015 Feb 11.

7.

Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.

Waniek A, Hartlage-Rübsamen M, Höfling C, Kehlen A, Schilling S, Demuth HU, Roßner S.

Biochim Biophys Acta. 2015 Jan;1852(1):146-55. doi: 10.1016/j.bbadis.2014.11.011. Epub 2014 Nov 18.

8.

High coexpression of CCL2 and CX3CL1 is gender-specifically associated with good prognosis in soft tissue sarcoma patients.

Kehlen A, Greither T, Wach S, Nolte E, Kappler M, Bache M, Holzhausen HJ, Lautenschläger C, Göbel S, Würl P, Immel UD, Agaimy A, Wullich B, Taubert H.

Int J Cancer. 2014 Nov 1;135(9):2096-106. doi: 10.1002/ijc.28867. Epub 2014 Apr 4.

9.

A non-canonical function of eukaryotic elongation factor 1A1: regulation of interleukin-6 expression.

Schulz I, Engel C, Niestroj AJ, Kehlen A, Rahfeld JU, Kleinschmidt M, Lehmann K, Roßner S, Demuth HU.

Biochim Biophys Acta. 2014 May;1843(5):965-75. doi: 10.1016/j.bbamcr.2014.01.022. Epub 2014 Jan 31.

10.

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease.

Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, Cynis H, Kehlen A, Arendt T, Hartlage-Rübsamen M, Demuth HU, Roßner S.

J Alzheimers Dis. 2014;39(2):385-400. doi: 10.3233/JAD-131535.

PMID:
24164736
11.

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.

Cynis H, Kehlen A, Haegele M, Hoffmann T, Heiser U, Fujii M, Shibazaki Y, Yoneyama H, Schilling S, Demuth HU.

Int J Exp Pathol. 2013 Jun;94(3):217-25. doi: 10.1111/iep.12020. Epub 2013 Apr 8.

12.

Role of glutaminyl cyclases in thyroid carcinomas.

Kehlen A, Haegele M, Menge K, Gans K, Immel UD, Hoang-Vu C, Klonisch T, Demuth HU.

Endocr Relat Cancer. 2013 Feb 18;20(1):79-90. doi: 10.1530/ERC-12-0053. Print 2013 Feb.

PMID:
23183267
13.

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway.

Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Rossner S, Demuth HU.

J Neuroinflammation. 2011 Jul 29;8:86. doi: 10.1186/1742-2094-8-86.

14.

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU.

EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20.

15.

Estrogen-independent actions of environmentally relevant AhR-agonists in human endometrial epithelial cells.

Willing C, Peich M, Danescu A, Kehlen A, Fowler PA, Hombach-Klonisch S.

Mol Hum Reprod. 2011 Feb;17(2):115-26. doi: 10.1093/molehr/gaq081. Epub 2010 Sep 27. Erratum in: Mol Hum Reprod. 2013 Jul;19(7):473.

PMID:
20876610
16.

Relaxin enhances S100A4 and promotes growth of human thyroid carcinoma cell xenografts.

Radestock Y, Willing C, Kehlen A, Hoang-Vu C, Hombach-Klonisch S.

Mol Cancer Res. 2010 Apr;8(4):494-506. doi: 10.1158/1541-7786.MCR-09-0307. Epub 2010 Mar 23.

17.

Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.

Geissler T, Brandt W, Porzel A, Schlenzig D, Kehlen A, Wessjohann L, Arnold N.

Bioorg Med Chem. 2010 Mar 15;18(6):2173-2177. doi: 10.1016/j.bmc.2010.01.074. Epub 2010 Feb 4.

PMID:
20176490
18.

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.

Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S.

Nat Med. 2008 Oct;14(10):1106-11. doi: 10.1038/nm.1872. Epub 2008 Sep 28.

PMID:
18836460
19.

The cytoplasmic domain of proEGF negatively regulates motility and elastinolytic activity in thyroid carcinoma cells.

Glogowska A, Pyka J, Kehlen A, Los M, Perumal P, Weber E, Cheng SY, Hoang-Vu C, Klonisch T.

Neoplasia. 2008 Oct;10(10):1120-30.

20.

Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo.

Forssmann U, Stoetzer C, Stephan M, Kruschinski C, Skripuletz T, Schade J, Schmiedl A, Pabst R, Wagner L, Hoffmann T, Kehlen A, Escher SE, Forssmann WG, Elsner J, von Hörsten S.

J Immunol. 2008 Jul 15;181(2):1120-7.

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