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Items: 1 to 20 of 22

1.

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series.

Aspatwar A, Parvathaneni NK, Barker H, Anduran E, Supuran CT, Dubois L, Lambin P, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):109-117. doi: 10.1080/14756366.2019.1685510.

2.

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos.

Aspatwar A, Hammaren M, Parikka M, Parkkila S, Carta F, Bozdag M, Vullo D, Supuran CT.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):65-71. doi: 10.1080/14756366.2019.1683007.

3.

Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs.

Aspatwar A, Kairys V, Rala S, Parikka M, Bozdag M, Carta F, Supuran CT, Parkkila S.

Int J Mol Sci. 2019 Oct 17;20(20). pii: E5153. doi: 10.3390/ijms20205153. Review.

4.

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos.

Aspatwar A, Hammaren MM, Parikka M, Parkkila S.

J Vis Exp. 2019 Aug 25;(150). doi: 10.3791/59315.

PMID:
31498322
5.

Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1.

Aspatwar A, Tolvanen MEE, Schneider HP, Becker HM, Narkilahti S, Parkkila S, Deitmer JW.

FEBS Open Bio. 2019 Jul;9(7):1204-1211. doi: 10.1002/2211-5463.12647. Epub 2019 Jun 11.

6.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies.

Aspatwar A, Winum JY, Carta F, Supuran CT, Hammaren M, Parikka M, Parkkila S.

Molecules. 2018 Nov 8;23(11). pii: E2911. doi: 10.3390/molecules23112911. Review.

7.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. doi: 10.1080/14756366.2018.1482285.

8.

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.

Karjalainen SL, Haapasalo HK, Aspatwar A, Barker H, Parkkila S, Haapasalo JA.

BMC Cancer. 2018 May 23;18(1):584. doi: 10.1186/s12885-018-4493-4.

9.

An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii.

Aspatwar A, Haapanen S, Parkkila S.

Metabolites. 2018 Mar 13;8(1). pii: E22. doi: 10.3390/metabo8010022. Review.

10.

Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase.

Patrikainen MS, Tolvanen MEE, Aspatwar A, Barker HR, Ortutay C, Jänis J, Laitaoja M, Hytönen VP, Azizi L, Manandhar P, Jáger E, Vullo D, Kukkurainen S, Hilvo M, Supuran CT, Parkkila S.

PeerJ. 2017 Dec 7;5:e4128. doi: 10.7717/peerj.4128. eCollection 2017.

11.

An update on anticancer drug development and delivery targeting carbonic anhydrase IX.

Kazokaitė J, Aspatwar A, Parkkila S, Matulis D.

PeerJ. 2017 Nov 23;5:e4068. doi: 10.7717/peerj.4068. eCollection 2017.

12.

Zebrafish as a Model Organism for the Development of Drugs for Skin Cancer.

Bootorabi F, Manouchehri H, Changizi R, Barker H, Palazzo E, Saltari A, Parikka M, Pincelli C, Aspatwar A.

Int J Mol Sci. 2017 Jul 18;18(7). pii: E1550. doi: 10.3390/ijms18071550. Review.

13.

β-CA-specific inhibitor dithiocarbamate Fc14-584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis.

Aspatwar A, Hammarén M, Koskinen S, Luukinen B, Barker H, Carta F, Supuran CT, Parikka M, Parkkila S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):832-840. doi: 10.1080/14756366.2017.1332056.

14.

Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide.

Kazokaitė J, Aspatwar A, Kairys V, Parkkila S, Matulis D.

Drug Chem Toxicol. 2017 Jul;40(3):309-319. doi: 10.1080/01480545.2016.1223095. Epub 2016 Sep 6.

PMID:
27600313
15.

Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish.

Aspatwar A, Tolvanen ME, Ojanen MJ, Barker HR, Saralahti AK, Bäuerlein CA, Ortutay C, Pan P, Kuuslahti M, Parikka M, Rämet M, Parkkila S.

PLoS One. 2015 Jul 28;10(7):e0134263. doi: 10.1371/journal.pone.0134263. eCollection 2015.

16.

Carbonic anhydrase related proteins: molecular biology and evolution.

Aspatwar A, Tolvanen ME, Ortutay C, Parkkila S.

Subcell Biochem. 2014;75:135-56. doi: 10.1007/978-94-007-7359-2_8. Review.

PMID:
24146378
17.

An update on carbonic anhydrase-related proteins VIII, X and XI.

Aspatwar A, Tolvanen ME, Parkkila S.

J Enzyme Inhib Med Chem. 2013 Dec;28(6):1129-42. doi: 10.3109/14756366.2012.727813. Epub 2013 Jan 7. Review.

PMID:
23294106
18.

Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish.

Aspatwar A, Tolvanen ME, Jokitalo E, Parikka M, Ortutay C, Harjula SK, Rämet M, Vihinen M, Parkkila S.

Hum Mol Genet. 2013 Feb 1;22(3):417-32. doi: 10.1093/hmg/dds438. Epub 2012 Oct 18.

PMID:
23087022
19.

Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes.

Tolvanen ME, Ortutay C, Barker HR, Aspatwar A, Patrikainen M, Parkkila S.

Bioorg Med Chem. 2013 Mar 15;21(6):1503-10. doi: 10.1016/j.bmc.2012.08.060. Epub 2012 Sep 10.

PMID:
23022279
20.

Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer.

Aspatwar A, Tolvanen ME, Ortutay C, Parkkila S.

Curr Pharm Des. 2010;16(29):3264-76. Review.

PMID:
20819067

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