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Items: 1 to 20 of 31

1.

Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage.

Kahremany S, Babaev I, Gvirtz R, Ogen-Stern N, Azoulay-Ginsburg S, Senderowitz H, Cohen G, Gruzman A.

Skin Pharmacol Physiol. 2019;32(4):173-181. doi: 10.1159/000499432. Epub 2019 May 10.

PMID:
31079103
2.

Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A.

Medchemcomm. 2018 Dec 13;10(2):280-293. doi: 10.1039/c8md00419f. eCollection 2019 Feb 1.

PMID:
30881615
3.

Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-( n-octylamino)pyrimidin-2(1 H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model.

Trifonov L, Nudelman V, Zhenin M, Matsree E, Afri M, Schmerling B, Cohen G, Jozwiak K, Weitman M, Korshin E, Senderowitz H, Shainberg A, Hochhauser E, Gruzman A.

J Med Chem. 2018 Dec 27;61(24):11309-11326. doi: 10.1021/acs.jmedchem.8b01471. Epub 2018 Dec 11.

PMID:
30507195
4.

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist.

Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A.

Med Chem. 2018;14(7):688-694. doi: 10.2174/1573406414666180412154952.

PMID:
29651942
5.

A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK.

Rozentul N, Avrahami Y, Shubely M, Levy L, Munder A, Cohen G, Cerasi E, Sasson S, Gruzman A.

Pharm Res. 2017 Dec;34(12):2873-2890. doi: 10.1007/s11095-017-2271-7. Epub 2017 Oct 5.

PMID:
28983714
6.

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Data Brief. 2017 Jul 28;14:329-336. doi: 10.1016/j.dib.2017.07.069. eCollection 2017 Oct.

7.

Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):1900-1910. doi: 10.1016/j.bbamem.2017.06.013. Epub 2017 Jun 23.

8.

Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.

Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A.

ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1189-1206. doi: 10.1021/acsami.6b10568. Epub 2017 Jan 3.

9.

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.

Ben-Hail D, Begas-Shvartz R, Shalev M, Shteinfer-Kuzmine A, Gruzman A, Reina S, De Pinto V, Shoshan-Barmatz V.

J Biol Chem. 2016 Nov 25;291(48):24986-25003. Epub 2016 Oct 13.

10.

Design and synthesis of novel protein kinase R (PKR) inhibitors.

Weintraub S, Yarnitzky T, Kahremany S, Barrera I, Viskind O, Rosenblum K, Niv MY, Gruzman A.

Mol Divers. 2016 Nov;20(4):805-819. Epub 2016 Aug 1.

PMID:
27480630
11.

A versatile water-soluble chelating and radical scavenging platform.

Eckshtain-Levi M, Lavi R, Yufit DS, Daniel B, Green O, Fleker O, Richman M, Rahimipour S, Gruzman A, Benisvy L.

Chem Commun (Camb). 2016 Feb 7;52(11):2350-3. doi: 10.1039/c5cc08198j.

PMID:
26731129
12.

SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex.

Weintraub S, Moskovitz Y, Fleker O, Levy AR, Meir A, Ruthstein S, Benisvy L, Gruzman A.

J Biol Inorg Chem. 2015 Dec;20(8):1287-98. doi: 10.1007/s00775-015-1307-x. Epub 2015 Nov 7.

PMID:
26547749
13.

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.

Lev N, Barhum Y, Ben-Zur T, Aharony I, Trifonov L, Regev N, Melamed E, Gruzman A, Offen D.

PLoS One. 2015 May 29;10(5):e0127549. doi: 10.1371/journal.pone.0127549. eCollection 2015.

14.

A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS).

Getter T, Zaks I, Barhum Y, Ben-Zur T, Böselt S, Gregoire S, Viskind O, Shani T, Gottlieb H, Green O, Shubely M, Senderowitz H, Israelson A, Kwon I, Petri S, Offen D, Gruzman A.

ChemMedChem. 2015 May;10(5):850-61. doi: 10.1002/cmdc.201500045. Epub 2015 Mar 13.

PMID:
25772747
15.

Antiproliferative Effect of Novel Aminoacridine-based Compounds.

Munder A, Moskovitz Y, Redko B, Levy AR, Ruthstein S, Gellerman G, Gruzman A.

Med Chem. 2015;11(4):373-82.

PMID:
25524547
16.

Activation of PPARδ: from computer modelling to biological effects.

Kahremany S, Livne A, Gruzman A, Senderowitz H, Sasson S.

Br J Pharmacol. 2015 Feb;172(3):754-70. doi: 10.1111/bph.12950. Epub 2014 Dec 15. Review.

17.

Activators of AMPK: not just for type II diabetes.

Zaks I, Getter T, Gruzman A.

Future Med Chem. 2014 Jul;6(11):1325-53. doi: 10.4155/fmc.14.74. Review.

PMID:
25163002
18.

Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress.

Shapira R, Rudnick S, Daniel B, Viskind O, Aisha V, Richman M, Ayasolla KR, Perelman A, Chill JH, Gruzman A, Rahimipour S.

J Med Chem. 2013 Sep 12;56(17):6709-18. doi: 10.1021/jm4005225. Epub 2013 Aug 28.

PMID:
23984871
19.

Riluzole increases the rate of glucose transport in L6 myotubes and NSC-34 motor neuron-like cells via AMPK pathway activation.

Daniel B, Green O, Viskind O, Gruzman A.

Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):434-43. doi: 10.3109/21678421.2013.808226. Epub 2013 Jul 8.

PMID:
23834207
20.

Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.

Meltzer-Mats E, Babai-Shani G, Pasternak L, Uritsky N, Getter T, Viskind O, Eckel J, Cerasi E, Senderowitz H, Sasson S, Gruzman A.

J Med Chem. 2013 Jul 11;56(13):5335-50. doi: 10.1021/jm4001488. Epub 2013 Jun 26.

PMID:
23750537

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