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Items: 13

1.

Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease: Lights and Shadows.

Xicoy H, Peñuelas N, Vila M, Laguna A.

Cells. 2019 Oct 25;8(11). pii: E1317. doi: 10.3390/cells8111317. Review.

2.

Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology.

Vila M, Laguna A, Carballo-Carbajal I.

Autophagy. 2019 Nov;15(11):2028-2030. doi: 10.1080/15548627.2019.1659621. Epub 2019 Sep 3.

3.

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.

Carballo-Carbajal I, Laguna A, Romero-Giménez J, Cuadros T, Bové J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Peñuelas N, Torra A, Rodríguez-Galván B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E, Vila M.

Nat Commun. 2019 Mar 7;10(1):973. doi: 10.1038/s41467-019-08858-y.

4.

The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.

Lassot I, Mora S, Lesage S, Zieba BA, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Soulet C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.

Cell Rep. 2018 Nov 27;25(9):2484-2496.e9. doi: 10.1016/j.celrep.2018.11.002.

5.

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.

Doucet-Beaupré H, Gilbert C, Profes MS, Chabrat A, Pacelli C, Giguère N, Rioux V, Charest J, Deng Q, Laguna A, Ericson J, Perlmann T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Lévesque M.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96. doi: 10.1073/pnas.1520387113. Epub 2016 Jul 12.

6.

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gómez-Galán M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T.

Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27.

PMID:
25915474
7.

Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Panman L, Papathanou M, Laguna A, Oosterveen T, Volakakis N, Acampora D, Kurtsdotter I, Yoshitake T, Kehr J, Joodmardi E, Muhr J, Simeone A, Ericson J, Perlmann T.

Cell Rep. 2014 Aug 21;8(4):1018-25. doi: 10.1016/j.celrep.2014.07.016. Epub 2014 Aug 7.

8.

Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome.

Laguna A, Barallobre MJ, Marchena MÁ, Mateus C, Ramírez E, Martínez-Cue C, Delabar JM, Castelo-Branco M, de la Villa P, Arbonés ML.

Hum Mol Genet. 2013 Jul 15;22(14):2775-84. doi: 10.1093/hmg/ddt125. Epub 2013 Mar 19.

PMID:
23512985
9.

α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.

Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Björklund A.

Sci Transl Med. 2012 Dec 5;4(163):163ra156. doi: 10.1126/scitranslmed.3004676. Erratum in: Sci Transl Med. 2016 Apr 20;8(335):335er4.

10.

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles.

Aranda S, Laguna A, de la Luna S.

FASEB J. 2011 Feb;25(2):449-62. doi: 10.1096/fj.10-165837. Epub 2010 Nov 3. Review.

PMID:
21048044
11.

Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.

Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sánchez P, Arbonés ML, Fariñas I.

Cell Stem Cell. 2010 Sep 3;7(3):367-79. doi: 10.1016/j.stem.2010.06.021.

12.

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.

Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernández E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbonés ML.

Dev Cell. 2008 Dec;15(6):841-53. doi: 10.1016/j.devcel.2008.10.014.

13.

Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.

Aranda S, Alvarez M, Turró S, Laguna A, de la Luna S.

Mol Cell Biol. 2008 Oct;28(19):5899-911. doi: 10.1128/MCB.00394-08. Epub 2008 Aug 4.

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