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Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa.

Goyard D, Thomas B, Gillon E, Imberty A, Renaudet O.

Front Chem. 2019 Oct 2;7:666. doi: 10.3389/fchem.2019.00666. eCollection 2019.


Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors.

Sommer R, Rox K, Wagner S, Hauck D, Henrikus SS, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, Varrot A, Hartmann RW, Titz A.

J Med Chem. 2019 Oct 24;62(20):9201-9216. doi: 10.1021/acs.jmedchem.9b01120. Epub 2019 Oct 11.


Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study.

Lepsik M, Sommer R, Kuhaudomlarp S, Lelimousin M, Paci E, Varrot A, Titz A, Imberty A.

Eur J Med Chem. 2019 Sep 1;177:212-220. doi: 10.1016/j.ejmech.2019.05.049. Epub 2019 May 18.


A Bioinformatics View of Glycan⁻Virus Interactions.

Le Mercier P, Mariethoz J, Lascano-Maillard J, Bonnardel F, Imberty A, Ricard-Blum S, Lisacek F.

Viruses. 2019 Apr 23;11(4). pii: E374. doi: 10.3390/v11040374. Review.


Selective high-resolution DNP-enhanced NMR of biomolecular binding sites.

Marin-Montesinos I, Goyard D, Gillon E, Renaudet O, Imberty A, Hediger S, De Paëpe G.

Chem Sci. 2019 Feb 1;10(11):3366-3374. doi: 10.1039/c8sc05696j. eCollection 2019 Mar 21.


Architecture and Evolution of Blade Assembly in β-propeller Lectins.

Bonnardel F, Kumar A, Wimmerova M, Lahmann M, Perez S, Varrot A, Lisacek F, Imberty A.

Structure. 2019 May 7;27(5):764-775.e3. doi: 10.1016/j.str.2019.02.002. Epub 2019 Mar 7.


Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins.

Wilhelm I, Levit-Zerdoun E, Jakob J, Villringer S, Frensch M, Übelhart R, Landi A, Müller P, Imberty A, Thuenauer R, Claudinon J, Jumaa H, Reth M, Eibel H, Hobeika E, Römer W.

Sci Signal. 2019 Mar 5;12(571). pii: eaao7194. doi: 10.1126/scisignal.aao7194.


Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions.

Denavit V, Lainé D, Bouzriba C, Shanina E, Gillon É, Fortin S, Rademacher C, Imberty A, Giguère D.

Chemistry. 2019 Mar 21;25(17):4478-4490. doi: 10.1002/chem.201806197. Epub 2019 Feb 27.


Expeditious Synthesis of C-Glycosyl Barbiturate Ligands of Bacterial Lectins: From Monomer Design to Glycoclusters and Glycopolymers.

Portier F, Imberty A, Halila S.

Bioconjug Chem. 2019 Mar 20;30(3):647-656. doi: 10.1021/acs.bioconjchem.8b00847. Epub 2019 Jan 10.


Tetraphenylethylene-based glycoclusters with aggregation-induced emission (AIE) properties as high-affinity ligands of bacterial lectins.

Donnier-Maréchal M, Abdullayev S, Bauduin M, Pascal Y, Fu MQ, He XP, Gillon E, Imberty A, Kipnis E, Dessein R, Vidal S.

Org Biomol Chem. 2018 Nov 21;16(45):8804-8809. doi: 10.1039/c8ob02035c.


Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells.

Ribeiro JP, Villringer S, Goyard D, Coche-Guerente L, Höferlin M, Renaudet O, Römer W, Imberty A.

Chem Sci. 2018 Aug 14;9(39):7634-7641. doi: 10.1039/c8sc02730g. eCollection 2018 Oct 21.


Human Bronchial Epithelial Cells Inhibit Aspergillus fumigatus Germination of Extracellular Conidia via FleA Recognition.

Richard N, Marti L, Varrot A, Guillot L, Guitard J, Hennequin C, Imberty A, Corvol H, Chignard M, Balloy V.

Sci Rep. 2018 Oct 24;8(1):15699. doi: 10.1038/s41598-018-33902-0.


Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches.

Soleilhac E, Brillet-Guéguen L, Roussel V, Prudent R, Touquet B, Dass S, Aci-Sèche S, Kasam V, Barette C, Imberty A, Breton V, Vantard M, Horvath D, Botté C, Tardieux I, Roy S, Maréchal E, Lafanechère L.

Int J Mol Sci. 2018 Oct 9;19(10). pii: E3085. doi: 10.3390/ijms19103085.


UniLectin3D, a database of carbohydrate binding proteins with curated information on 3D structures and interacting ligands.

Bonnardel F, Mariethoz J, Salentin S, Robin X, Schroeder M, Perez S, Lisacek F, Imberty A.

Nucleic Acids Res. 2019 Jan 8;47(D1):D1236-D1244. doi: 10.1093/nar/gky832.


Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin.

Dingjan T, Gillon É, Imberty A, Pérez S, Titz A, Ramsland PA, Yuriev E.

J Chem Inf Model. 2018 Sep 24;58(9):1976-1989. doi: 10.1021/acs.jcim.8b00185. Epub 2018 Sep 4.


Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs.

Tobola F, Lelimousin M, Varrot A, Gillon E, Darnhofer B, Blixt O, Birner-Gruenberger R, Imberty A, Wiltschi B.

ACS Chem Biol. 2018 Aug 17;13(8):2211-2219. doi: 10.1021/acschembio.8b00377. Epub 2018 Jun 12.


Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.

Villringer S, Madl J, Sych T, Manner C, Imberty A, Römer W.

Sci Rep. 2018 Jan 31;8(1):1932. doi: 10.1038/s41598-018-20230-6.


Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.

Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A.

J Am Chem Soc. 2018 Feb 21;140(7):2537-2545. doi: 10.1021/jacs.7b11133. Epub 2018 Jan 22.


Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens.

Goyard D, Baldoneschi V, Varrot A, Fiore M, Imberty A, Richichi B, Renaudet O, Nativi C.

Bioconjug Chem. 2018 Jan 17;29(1):83-88. doi: 10.1021/acs.bioconjchem.7b00616. Epub 2017 Dec 26.


Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: synthesis, binding studies and anti-adhesive properties.

Donnier-Maréchal M, Galanos N, Grandjean T, Pascal Y, Ji DK, Dong L, Gillon E, He XP, Imberty A, Kipnis E, Dessein R, Vidal S.

Org Biomol Chem. 2017 Dec 6;15(47):10037-10043. doi: 10.1039/c7ob02749d.


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