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Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition.

Das NA, Carpenter AJ, Belenchia A, Aroor AR, Noda M, Siebenlist U, Chandrasekar B, DeMarco VG.

Cell Signal. 2019 Dec 17;68:109506. doi: 10.1016/j.cellsig.2019.109506. [Epub ahead of print]


Chronic Elevation of Endothelin-1 Alone May Not Be Sufficient to Impair Endothelium-Dependent Relaxation.

Grunewald ZI, Jurrissen TJ, Woodford ML, Ramirez-Perez FI, Park LK, Pettit-Mee R, Ghiarone T, Brown SM, Morales-Quinones M, Ball JR, Staveley-O'Carroll KF, Aroor AR, Fadel PJ, Paradis P, Schiffrin EL, Bender SB, Martinez-Lemus LA, Padilla J.

Hypertension. 2019 Dec;74(6):1409-1419. doi: 10.1161/HYPERTENSIONAHA.119.13676. Epub 2019 Oct 21.


Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice.

Padilla J, Woodford ML, Lastra-Gonzalez G, Martinez-Diaz V, Fujie S, Yang Y, Lising AMC, Ramirez-Perez FI, Aroor AR, Morales-Quinones M, Ghiarone T, Whaley-Connell A, Martinez-Lemus LA, Hill MA, Manrique-Acevedo C.

Endocrinology. 2019 Dec 1;160(12):2918-2928. doi: 10.1210/en.2019-00483.


Utility of obesity and metabolic dyslipidemia (a non-insulin based determinate of the metabolic syndrome and insulin resistance) in predicting arterial stiffness.

Aroor AR, Whaley-Connell A, Sowers JR.

J Clin Hypertens (Greenwich). 2019 Aug;21(8):1071-1074. doi: 10.1111/jch.13615. Epub 2019 Jul 18.


Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice.

Sowers JR, Habibi J, Aroor AR, Yang Y, Lastra G, Hill MA, Whaley-Connell A, Jaisser F, Jia G.

Metabolism. 2019 Oct;99:57-66. doi: 10.1016/j.metabol.2019.153946. Epub 2019 Jul 11.


Binge Alcohol Is More Injurious to Liver in Female than in Male Rats: Histopathological, Pharmacologic, and Epigenetic Profiles.

Shukla SD, Restrepo R, Aroor AR, Liu X, Lim RW, Franke JD, Ford DA, Korthuis RJ.

J Pharmacol Exp Ther. 2019 Sep;370(3):390-398. doi: 10.1124/jpet.119.258871. Epub 2019 Jul 1.


Endothelial cell senescence in aging-related vascular dysfunction.

Jia G, Aroor AR, Jia C, Sowers JR.

Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1802-1809. doi: 10.1016/j.bbadis.2018.08.008. Epub 2018 Aug 18. Review.


The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat.

Habibi J, Aroor AR, Das NA, Manrique-Acevedo CM, Johnson MS, Hayden MR, Nistala R, Wiedmeyer C, Chandrasekar B, DeMarco VG.

Cardiovasc Diabetol. 2019 Mar 25;18(1):40. doi: 10.1186/s12933-019-0847-8.


Empagliflozin Ameliorates Type 2 Diabetes-Induced Ultrastructural Remodeling of the Neurovascular Unit and Neuroglia in the Female db/db Mouse.

Hayden MR, Grant DG, Aroor AR, DeMarco VG.

Brain Sci. 2019 Mar 7;9(3). pii: E57. doi: 10.3390/brainsci9030057.


Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor.

Aroor AR, Habibi J, Nistala R, Ramirez-Perez FI, Martinez-Lemus LA, Jaffe IZ, Sowers JR, Jia G, Whaley-Connell A.

Hypertension. 2019 Apr;73(4):849-858. doi: 10.1161/HYPERTENSIONAHA.118.12198.


Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.

Sharma N, Dev R, Belenchia AM, Aroor AR, Whaley-Connell A, Pulakat L, Hans CP.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):212-223. doi: 10.1161/ATVBAHA.118.311969.


Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury.

Aroor AR, Das NA, Carpenter AJ, Habibi J, Jia G, Ramirez-Perez FI, Martinez-Lemus L, Manrique-Acevedo CM, Hayden MR, Duta C, Nistala R, Mayoux E, Padilla J, Chandrasekar B, DeMarco VG.

Cardiovasc Diabetol. 2018 Jul 30;17(1):108. doi: 10.1186/s12933-018-0750-8.


Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness.

Jia G, Aroor AR, Hill MA, Sowers JR.

Hypertension. 2018 Sep;72(3):537-548. doi: 10.1161/HYPERTENSIONAHA.118.11065. Review. No abstract available.


Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction.

Jia G, Habibi J, Aroor AR, Hill MA, Yang Y, Whaley-Connell A, Jaisser F, Sowers JR.

Hypertension. 2018 Sep;72(3):731-738. doi: 10.1161/HYPERTENSIONAHA.118.11339.


Potential Role of Antihypertensive Medications in Preventing Excessive Arterial Stiffening.

Jia G, Aroor AR, Martinez-Lemus LA, Sowers JR.

Curr Hypertens Rep. 2018 Jul 6;20(9):76. doi: 10.1007/s11906-018-0876-9. Review.


The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin.

Aroor AR, Manrique-Acevedo C, DeMarco VG.

Cardiovasc Diabetol. 2018 Apr 18;17(1):59. doi: 10.1186/s12933-018-0704-1. Review.


Cellular mechanisms underlying obesity-induced arterial stiffness.

Aroor AR, Jia G, Sowers JR.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R387-R398. doi: 10.1152/ajpregu.00235.2016. Epub 2017 Nov 22. Review.


Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.

Brown SM, Smith CE, Meuth AI, Khan M, Aroor AR, Cleeton HM, Meininger GA, Sowers JR, DeMarco VG, Chandrasekar B, Nistala R, Bender SB.

Endocrinology. 2017 Oct 1;158(10):3592-3604. doi: 10.1210/en.2017-00416.


Enhanced endothelium epithelial sodium channel signaling prompts left ventricular diastolic dysfunction in obese female mice.

Jia G, Habibi J, Aroor AR, Hill MA, DeMarco VG, Lee LE, Ma L, Barron BJ, Whaley-Connell A, Sowers JR.

Metabolism. 2018 Jan;78:69-79. doi: 10.1016/j.metabol.2017.08.008. Epub 2017 Sep 8.


The role of mineralocorticoid receptor signaling in the cross-talk between adipose tissue and the vascular wall.

Jia G, Aroor AR, Sowers JR.

Cardiovasc Res. 2017 Jul 1;113(9):1055-1063. doi: 10.1093/cvr/cvx097. Review.

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