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Items: 1 to 20 of 72

1.

In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned.

Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL, Pitkänen A.

Int J Mol Sci. 2019 Oct 29;20(21). pii: E5395. doi: 10.3390/ijms20215395.

2.

NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes.

Oksanen M, Hyötyläinen I, Trontti K, Rolova T, Wojciechowski S, Koskuvi M, Viitanen M, Levonen AL, Hovatta I, Roybon L, Lehtonen Š, Kanninen KM, Hämäläinen RH, Koistinaho J.

Glia. 2019 Oct 31. doi: 10.1002/glia.23741. [Epub ahead of print]

PMID:
31670864
3.

Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma.

Pölönen P, Jawahar Deen A, Leinonen HM, Jyrkkänen HK, Kuosmanen S, Mononen M, Jain A, Tuomainen T, Pasonen-Seppänen S, Hartikainen JM, Mannermaa A, Nykter M, Tavi P, Johansen T, Heinäniemi M, Levonen AL.

Oncogene. 2019 Aug 23. doi: 10.1038/s41388-019-0956-6. [Epub ahead of print]

PMID:
31444413
4.

Characterizing valve dynamics in mice by high-resolution cine-MRI.

Weisell J, Ruotsalainen AK, Laakso H, Ylä-Herttuala E, Näpänkangas J, Levonen AL, Liimatainen T, Rysä J.

NMR Biomed. 2019 Aug;32(8):e4108. doi: 10.1002/nbm.4108. Epub 2019 May 21.

PMID:
31112347
5.

Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function.

Jauhiainen S, Laakkonen JP, Ketola K, Toivanen PI, Nieminen T, Ninchoji T, Levonen AL, Kaikkonen MU, Ylä-Herttuala S.

Front Physiol. 2019 Mar 12;10:224. doi: 10.3389/fphys.2019.00224. eCollection 2019.

6.

Regulation of stress signaling pathways by protein lipoxidation.

Patinen T, Adinolfi S, Cortés CC, Härkönen J, Jawahar Deen A, Levonen AL.

Redox Biol. 2019 May;23:101114. doi: 10.1016/j.redox.2019.101114. Epub 2019 Jan 16. Review.

7.

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.

Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT.

Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Review.

PMID:
30610225
8.

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K.

Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.

9.

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells.

Kuosmanen SM, Sihvola V, Kansanen E, Kaikkonen MU, Levonen AL.

Redox Biol. 2018 Sep;18:77-83. doi: 10.1016/j.redox.2018.06.007. Epub 2018 Jun 22.

10.

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice.

Ruotsalainen AK, Lappalainen JP, Heiskanen E, Merentie M, Sihvola V, Näpänkangas J, Lottonen-Raikaslehto L, Kansanen E, Adinolfi S, Kaarniranta K, Ylä-Herttuala S, Jauhiainen M, Pirinen E, Levonen AL.

Cardiovasc Res. 2019 Jan 1;115(1):243-254. doi: 10.1093/cvr/cvy143.

PMID:
29917052
11.

Regulation of stress signaling pathways by nitro-fatty acids.

Deen AJ, Sihvola V, Härkönen J, Patinen T, Adinolfi S, Levonen AL.

Nitric Oxide. 2018 Mar 19. pii: S1089-8603(17)30323-3. doi: 10.1016/j.niox.2018.03.012. [Epub ahead of print] Review.

PMID:
29567143
12.

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation.

Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen HK, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokki H, Tavi P, Heikkinen S, Levonen AL.

Nucleic Acids Res. 2018 Feb 16;46(3):1124-1138. doi: 10.1093/nar/gkx1155.

13.

MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells.

Kuosmanen SM, Kansanen E, Sihvola V, Levonen AL.

Sci Rep. 2017 Sep 8;7(1):10943. doi: 10.1038/s41598-017-11487-4.

14.

Nitro-Oleic Acid Regulates Endothelin Signaling in Human Endothelial Cells.

Kansanen E, Kuosmanen SM, Ruotsalainen AK, Hynynen H, Levonen AL.

Mol Pharmacol. 2017 Oct;92(4):481-490. doi: 10.1124/mol.117.109751. Epub 2017 Aug 4.

PMID:
28778983
15.

Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling.

Abushik PA, Bart G, Korhonen P, Leinonen H, Giniatullina R, Sibarov DA, Levonen AL, Malm T, Antonov SM, Giniatullin R.

Cephalalgia. 2017 Dec;37(14):1373-1383. doi: 10.1177/0333102416681588. Epub 2016 Nov 25.

PMID:
27884929
16.

Keap1 as the redox sensor of the antioxidant response.

Sihvola V, Levonen AL.

Arch Biochem Biophys. 2017 Mar 1;617:94-100. doi: 10.1016/j.abb.2016.10.010. Epub 2016 Oct 18. Review.

PMID:
27769838
17.

Hemin and Cobalt Protoporphyrin Inhibit NLRP3 Inflammasome Activation by Enhancing Autophagy: A Novel Mechanism of Inflammasome Regulation.

Nurmi K, Kareinen I, Virkanen J, Rajamäki K, Kouri VP, Vaali K, Levonen AL, Fyhrquist N, Matikainen S, Kovanen PT, Eklund KK.

J Innate Immun. 2017;9(1):65-82. doi: 10.1159/000448894. Epub 2016 Sep 22.

18.

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.

Liddell JR, Lehtonen S, Duncan C, Keksa-Goldsteine V, Levonen AL, Goldsteins G, Malm T, White AR, Koistinaho J, Kanninen KM.

J Neuroinflammation. 2016 Feb 26;13:49. doi: 10.1186/s12974-016-0515-9.

19.

The Effects of Sequence Variation on Genome-wide NRF2 Binding--New Target Genes and Regulatory SNPs.

Kuosmanen SM, Viitala S, Laitinen T, Peräkylä M, Pölönen P, Kansanen E, Leinonen H, Raju S, Wienecke-Baldacchino A, Närvänen A, Poso A, Heinäniemi M, Heikkinen S, Levonen AL.

Nucleic Acids Res. 2016 Feb 29;44(4):1760-75. doi: 10.1093/nar/gkw052. Epub 2016 Jan 29.

20.

Dysregulation of the Keap1-Nrf2 pathway in cancer.

Leinonen HM, Kansanen E, Pölönen P, Heinäniemi M, Levonen AL.

Biochem Soc Trans. 2015 Aug;43(4):645-9. doi: 10.1042/BST20150048. Epub 2015 Aug 3. Review.

PMID:
26551706

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