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Items: 1 to 20 of 36

1.

Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.

Zangerl-Plessl EM, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P, Stary-Weinzinger A, Nichols CG.

J Gen Physiol. 2019 Nov 19. pii: jgp.201912422. doi: 10.1085/jgp.201912422. [Epub ahead of print]

PMID:
31744859
2.

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking.

Zangerl-Plessl EM, Qile M, Bloothooft M, Stary-Weinzinger A, van der Heyden MAG.

Biomolecules. 2019 Oct 25;9(11). pii: E650. doi: 10.3390/biom9110650. Review.

3.

Conduction through a narrow inward-rectifier K+ channel pore.

Bernsteiner H, Zangerl-Plessl EM, Chen X, Stary-Weinzinger A.

J Gen Physiol. 2019 Oct 7;151(10):1231-1246. doi: 10.1085/jgp.201912359. Epub 2019 Sep 11.

4.

LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.

Qile M, Beekman HDM, Sprenkeler DJ, Houtman MJC, van Ham WB, Stary-Weinzinger A, Beyl S, Hering S, van den Berg DJ, de Lange ECM, Heitman LH, IJzerman AP, Vos MA, van der Heyden MAG.

Br J Pharmacol. 2019 Oct;176(19):3871-3885. doi: 10.1111/bph.14798. Epub 2019 Aug 30.

5.

A structural model of the human serotonin transporter in an outward-occluded state.

Hellsberg E, Ecker GF, Stary-Weinzinger A, Forrest LR.

PLoS One. 2019 Jun 28;14(6):e0217377. doi: 10.1371/journal.pone.0217377. eCollection 2019.

6.

Computational Identification of Novel Kir6 Channel Inhibitors.

Chen X, Garon A, Wieder M, Houtman MJC, Zangerl-Plessl EM, Langer T, van der Heyden MAG, Stary-Weinzinger A.

Front Pharmacol. 2019 May 24;10:549. doi: 10.3389/fphar.2019.00549. eCollection 2019.

7.

Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents.

Houtman MJC, Chen X, Qile M, Duran K, van Haaften G, Stary-Weinzinger A, van der Heyden MAG.

J Cell Mol Med. 2019 Aug;23(8):4962-4969. doi: 10.1111/jcmm.14329. Epub 2019 May 22.

8.

Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go channel superfamily member Kv 12.1.

Dierich M, van Ham WB, Stary-Weinzinger A, Leitner MG.

Br J Pharmacol. 2019 Aug;176(15):2708-2723. doi: 10.1111/bph.14693. Epub 2019 Jun 17.

9.

Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole.

Gualdani R, Cavalluzzi MM, Tadini-Buoninsegni F, Convertino M, Gailly P, Stary-Weinzinger A, Lentini G.

Cell Physiol Biochem. 2018;45(6):2233-2245. doi: 10.1159/000488169. Epub 2018 Mar 10.

10.

Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo.

Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S.

Pharmacol Res. 2018 May;131:150-163. doi: 10.1016/j.phrs.2018.02.024. Epub 2018 Mar 15.

11.

Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.

Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.

Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.

12.

Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

Cooper PE, McClenaghan C, Chen X, Stary-Weinzinger A, Nichols CG.

J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.

13.

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.

Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K, van Haaften G, Zangerl-Plessl EM, Takanari H, Stary-Weinzinger A, van der Heyden MAG.

J Biomed Sci. 2017 Jul 15;24(1):44. doi: 10.1186/s12929-017-0352-x.

14.

Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti MC.

Mol Pharmacol. 2017 Oct;92(4):437-450. doi: 10.1124/mol.117.108886. Epub 2017 Jul 13.

15.

Dynamics of the EAG1 K+ channel selectivity filter assessed by molecular dynamics simulations.

Bernsteiner H, Bründl M, Stary-Weinzinger A.

Biochem Biophys Res Commun. 2017 Feb 26;484(1):107-112. doi: 10.1016/j.bbrc.2017.01.064. Epub 2017 Jan 19.

16.

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.

Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG.

J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug 15.

17.

Drug trapping in hERG K+ channels: (not) a matter of drug size?

Linder T, Bernsteiner H, Saxena P, Bauer F, Erker T, Timin E, Hering S, Stary-Weinzinger A.

Medchemcomm. 2016 Mar 1;7(3):512-518. doi: 10.1039/c5md00443h. Epub 2015 Dec 22.

18.

Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels.

Linder T, Wang S, Zangerl-Plessl EM, Nichols CG, Stary-Weinzinger A.

J Chem Inf Model. 2015 Apr 27;55(4):814-22. doi: 10.1021/acs.jcim.5b00010. Epub 2015 Apr 3.

19.

Structural insights into trapping and dissociation of small molecules in K⁺ channels.

Linder T, Saxena P, Timin E, Hering S, Stary-Weinzinger A.

J Chem Inf Model. 2014 Nov 24;54(11):3218-28. doi: 10.1021/ci500353r. Epub 2014 Oct 21.

PMID:
25297379
20.

Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

Houtman MJ, Korte SM, Ji Y, Kok B, Vos MA, Stary-Weinzinger A, van der Heyden MA.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):992-7. doi: 10.1016/j.bbrc.2014.09.031. Epub 2014 Sep 16.

PMID:
25223803

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