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Items: 1 to 20 of 48


Genome-wide identification of transcriptional start sites in the haloarchaeon Haloferax volcanii based on differential RNA-Seq (dRNA-Seq).

Babski J, Haas KA, Näther-Schindler D, Pfeiffer F, Förstner KU, Hammelmann M, Hilker R, Becker A, Sharma CM, Marchfelder A, Soppa J.

BMC Genomics. 2016 Aug 12;17(1):629. doi: 10.1186/s12864-016-2920-y.


Gene Repression in Haloarchaea Using the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas I-B System.

Stachler AE, Marchfelder A.

J Biol Chem. 2016 Jul 15;291(29):15226-42. doi: 10.1074/jbc.M116.724062.


The role of Cas8 in type I CRISPR interference.

Cass SD, Haas KA, Stoll B, Alkhnbashi OS, Sharma K, Urlaub H, Backofen R, Marchfelder A, Bolt EL.

Biosci Rep. 2015 May 5;35(3). pii: e00197. doi: 10.1042/BSR20150043.


Analysis of protein-RNA interactions in CRISPR proteins and effector complexes by UV-induced cross-linking and mass spectrometry.

Sharma K, Hrle A, Kramer K, Sachsenberg T, Staals RH, Randau L, Marchfelder A, van der Oost J, Kohlbacher O, Conti E, Urlaub H.

Methods. 2015 Nov 1;89:138-48. doi: 10.1016/j.ymeth.2015.06.005.


Deletion of the Sm1 encoding motif in the lsm gene results in distinct changes in the transcriptome and enhanced swarming activity of Haloferax cells.

Maier LK, Benz J, Fischer S, Alstetter M, Jaschinski K, Hilker R, Becker A, Allers T, Soppa J, Marchfelder A.

Biochimie. 2015 Oct;117:129-37. doi: 10.1016/j.biochi.2015.02.023.


The Adaptive Immune System of Haloferax volcanii.

Maier LK, Dyall-Smith M, Marchfelder A.

Life (Basel). 2015 Feb 16;5(1):521-37. doi: 10.3390/life5010521. Review.


An active immune defense with a minimal CRISPR (clustered regularly interspaced short palindromic repeats) RNA and without the Cas6 protein.

Maier LK, Stachler AE, Saunders SJ, Backofen R, Marchfelder A.

J Biol Chem. 2015 Feb 13;290(7):4192-201. doi: 10.1074/jbc.M114.617506.


Structural analyses of the CRISPR protein Csc2 reveal the RNA-binding interface of the type I-D Cas7 family.

Hrle A, Maier LK, Sharma K, Ebert J, Basquin C, Urlaub H, Marchfelder A, Conti E.

RNA Biol. 2014;11(8):1072-82. doi: 10.4161/rna.29893.


Small regulatory RNAs in Archaea.

Babski J, Maier LK, Heyer R, Jaschinski K, Prasse D, Jäger D, Randau L, Schmitz RA, Marchfelder A, Soppa J.

RNA Biol. 2014;11(5):484-93. Review.


Generation and phenotyping of a collection of sRNA gene deletion mutants of the haloarchaeon Haloferax volcanii.

Jaschinski K, Babski J, Lehr M, Burmester A, Benz J, Heyer R, Dörr M, Marchfelder A, Soppa J.

PLoS One. 2014 Mar 17;9(3):e90763. doi: 10.1371/journal.pone.0090763.


A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii.

Brendel J, Stoll B, Lange SJ, Sharma K, Lenz C, Stachler AE, Maier LK, Richter H, Nickel L, Schmitz RA, Randau L, Allers T, Urlaub H, Backofen R, Marchfelder A.

J Biol Chem. 2014 Mar 7;289(10):7164-77. doi: 10.1074/jbc.M113.508184.


Requirements for a successful defence reaction by the CRISPR-Cas subtype I-B system.

Stoll B, Maier LK, Lange SJ, Brendel J, Fischer S, Backofen R, Marchfelder A.

Biochem Soc Trans. 2013 Dec;41(6):1444-8. doi: 10.1042/BST20130098. Review.


tRNA 3' processing in yeast involves tRNase Z, Rex1, and Rrp6.

Skowronek E, Grzechnik P, Späth B, Marchfelder A, Kufel J.

RNA. 2014 Jan;20(1):115-30. doi: 10.1261/rna.041467.113.


RNA-Pareto: interactive analysis of Pareto-optimal RNA sequence-structure alignments.

Schnattinger T, Schöning U, Marchfelder A, Kestler HA.

Bioinformatics. 2013 Dec 1;29(23):3102-4. doi: 10.1093/bioinformatics/btt536.


Special focus CRISPR-Cas.

Marchfelder A.

RNA Biol. 2013 May;10(5):655-8. doi: 10.4161/rna.24687. No abstract available.


Essential requirements for the detection and degradation of invaders by the Haloferax volcanii CRISPR/Cas system I-B.

Maier LK, Lange SJ, Stoll B, Haas KA, Fischer S, Fischer E, Duchardt-Ferner E, Wöhnert J, Backofen R, Marchfelder A.

RNA Biol. 2013 May;10(5):865-74. doi: 10.4161/rna.24282.


The immune system of halophilic archaea.

Maier LK, Fischer S, Stoll B, Brendel J, Pfeiffer F, Dyall-Smith M, Marchfelder A.

Mob Genet Elements. 2012 Sep 1;2(5):228-232.


The ring of confidence: a haloarchaeal CRISPR/Cas system.

Maier LK, Stoll B, Brendel J, Fischer S, Pfeiffer F, Dyall-Smith M, Marchfelder A.

Biochem Soc Trans. 2013 Feb 1;41(1):374-8. doi: 10.1042/BST20120263.


An archaeal immune system can detect multiple protospacer adjacent motifs (PAMs) to target invader DNA.

Fischer S, Maier LK, Stoll B, Brendel J, Fischer E, Pfeiffer F, Dyall-Smith M, Marchfelder A.

J Biol Chem. 2012 Sep 28;287(40):33351-63.


High throughput sequencing reveals a plethora of small RNAs including tRNA derived fragments in Haloferax volcanii.

Heyer R, Dörr M, Jellen-Ritter A, Späth B, Babski J, Jaschinski K, Soppa J, Marchfelder A.

RNA Biol. 2012 Jul;9(7):1011-8. doi: 10.4161/rna.20826.

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