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Items: 1 to 20 of 35

1.

A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.

Andrisano V, Naldi M, De Simone A, Bartolini M.

Expert Opin Ther Pat. 2018 Jun;28(6):455-465. doi: 10.1080/13543776.2018.1476494. Review.

PMID:
29757691
2.

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors.

Hulcová D, Breiterová K, Siatka T, Klímová K, Davani L, Šafratová M, Hošťálková A, De Simone A, Andrisano V, Cahlíková L.

Molecules. 2018 Mar 21;23(4). pii: E719. doi: 10.3390/molecules23040719.

3.

Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET.

Neiens P, De Simone A, Ramershoven A, Höfner G, Allmendinger L, Wanner KT.

Biomed Chromatogr. 2018 Jul;32(7):e4231. doi: 10.1002/bmc.4231. Epub 2018 Apr 10.

PMID:
29500932
4.

The Role of Chromatography in Alzheimer's Disease Drug Discovery.

Fiori J, De Simone A, Naldi M, Andrisano V.

Adv Chromatogr. 2017;53:75-107. Review. No abstract available.

PMID:
29461692
5.

Simultaneous Multiple MS Binding Assays for the Dopamine, Norepinephrine, and Serotonin Transporters.

Neiens P, De Simone A, Höfner G, Wanner KT.

ChemMedChem. 2018 Mar 6;13(5):453-463. doi: 10.1002/cmdc.201700737. Epub 2018 Feb 16.

PMID:
29451362
6.

Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death.

Basso M, Chen HH, Tripathy D, Conte M, Apperley KYP, De Simone A, Keillor JW, Ratan R, Nebbioso A, Sarno F, Altucci L, Milelli A.

ChemMedChem. 2018 Feb 6;13(3):227-230. doi: 10.1002/cmdc.201700601. Epub 2018 Jan 18.

PMID:
29286587
7.

Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease.

De Simone A, Bartolini M, Baschieri A, Apperley KYP, Chen HH, Guardigni M, Montanari S, Kobrlova T, Soukup O, Valgimigli L, Andrisano V, Keillor JW, Basso M, Milelli A.

Eur J Med Chem. 2017 Oct 20;139:378-389. doi: 10.1016/j.ejmech.2017.07.058. Epub 2017 Jul 25.

PMID:
28810189
8.

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.

Pérez-Areales FJ, Betari N, Viayna A, Pont C, Espargaró A, Bartolini M, De Simone A, Rinaldi Alvarenga JF, Pérez B, Sabate R, Lamuela-Raventós RM, Andrisano V, Luque FJ, Muñoz-Torrero D.

Future Med Chem. 2017 Jun;9(10):965-981. doi: 10.4155/fmc-2017-0049. Epub 2017 Jun 20.

PMID:
28632395
9.

Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development§.

Milelli A, De Simone A, Ticchi N, Chen HH, Betari N, Andrisano V, Tumiatti V.

Curr Med Chem. 2017;24(32):3522-3546. doi: 10.2174/0929867324666170309123920. Review.

PMID:
28294041
10.

Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors.

De Simone A, Fiori J, Naldi M, D'Urzo A, Tumiatti V, Milelli A, Andrisano V.

J Pharm Biomed Anal. 2017 Sep 10;144:159-166. doi: 10.1016/j.jpba.2017.02.036. Epub 2017 Feb 27.

PMID:
28268049
11.

Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease.

Seidl C, de Moraes Santos CA, De Simone A, Bartolini M, Weffort-Santos AM, Andrisano V.

Curr Alzheimer Res. 2017;14(3):317-326. doi: 10.2174/1567205013666161026150455.

PMID:
27784218
12.

Naturally Inspired Molecules as Multifunctional Agents for Alzheimer's Disease Treatment.

Rampa A, Tarozzi A, Mancini F, Pruccoli L, Di Martino RM, Gobbi S, Bisi A, De Simone A, Palomba F, Zaccheroni N, Belluti F.

Molecules. 2016 May 16;21(5). pii: E643. doi: 10.3390/molecules21050643.

13.

Direct determination of GSK-3β activity and inhibition by UHPLC-UV-vis diode arrays detector (DAD).

D'Urzo A, De Simone A, Fiori J, Naldi M, Milelli A, Andrisano V.

J Pharm Biomed Anal. 2016 May 30;124:104-111. doi: 10.1016/j.jpba.2016.02.029. Epub 2016 Feb 23.

PMID:
26942334
14.

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets.

Chlebek J, De Simone A, Hošťálková A, Opletal L, Pérez C, Pérez DI, Havlíková L, Cahlíková L, Andrisano V.

Fitoterapia. 2016 Mar;109:241-7. doi: 10.1016/j.fitote.2016.01.008. Epub 2016 Jan 11.

PMID:
26779945
15.

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.

Di Martino RM, De Simone A, Andrisano V, Bisignano P, Bisi A, Gobbi S, Rampa A, Fato R, Bergamini C, Perez DI, Martinez A, Bottegoni G, Cavalli A, Belluti F.

J Med Chem. 2016 Jan 28;59(2):531-44. doi: 10.1021/acs.jmedchem.5b00894. Epub 2016 Jan 7.

PMID:
26696252
16.

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.

Zha X, Lamba D, Zhang L, Lou Y, Xu C, Kang D, Chen L, Xu Y, Zhang L, De Simone A, Samez S, Pesaresi A, Stojan J, Lopez MG, Egea J, Andrisano V, Bartolini M.

J Med Chem. 2016 Jan 14;59(1):114-31. doi: 10.1021/acs.jmedchem.5b01119. Epub 2015 Dec 29.

PMID:
26632651
17.

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease.

Prati F, De Simone A, Armirotti A, Summa M, Pizzirani D, Scarpelli R, Bertozzi SM, Perez DI, Andrisano V, Perez-Castillo A, Monti B, Massenzio F, Polito L, Racchi M, Sabatino P, Bottegoni G, Martinez A, Cavalli A, Bolognesi ML.

ACS Chem Neurosci. 2015 Oct 21;6(10):1665-82. doi: 10.1021/acschemneuro.5b00121. Epub 2015 Aug 3.

18.

From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.

Rampa A, Mancini F, De Simone A, Falchi F, Belluti F, Di Martino RM, Gobbi S, Andrisano V, Tarozzi A, Bartolini M, Cavalli A, Bisi A.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2804-8. doi: 10.1016/j.bmcl.2015.05.002. Epub 2015 May 9.

PMID:
26003339
19.

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.

Prati F, De Simone A, Bisignano P, Armirotti A, Summa M, Pizzirani D, Scarpelli R, Perez DI, Andrisano V, Perez-Castillo A, Monti B, Massenzio F, Polito L, Racchi M, Favia AD, Bottegoni G, Martinez A, Bolognesi ML, Cavalli A.

Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1578-82. doi: 10.1002/anie.201410456. Epub 2014 Dec 11.

PMID:
25504761
20.

Reprint of: Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate.

De Simone A, Seidl C, Santos CA, Andrisano V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 1;968:94-100. doi: 10.1016/j.jchromb.2014.05.009. Epub 2014 May 17.

PMID:
24932540

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