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Primary cilia defects causing mitral valve prolapse.

Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott JJ, Bouatia-Naji N, Slaugenhaupt SA, Norris RA.

Sci Transl Med. 2019 May 22;11(493). pii: eaax0290. doi: 10.1126/scitranslmed.aax0290.


Mesothelium and Malignant Mesothelioma.

Hiriart E, Deepe R, Wessels A.

J Dev Biol. 2019 Apr 8;7(2). pii: E7. doi: 10.3390/jdb7020007. Review.


A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return.

Burns TA, Deepe RN, Bullard J, Phelps AL, Toomer KA, Hiriart E, Norris RA, Haycraft CJ, Wessels A.

Anat Rec (Hoboken). 2019 Jan;302(1):136-145. doi: 10.1002/ar.23909. Epub 2018 Oct 5.


The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse.

Lockhart MM, van den Hoff M, Wessels A.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 20.
2016 Jun 25.


A role for primary cilia in aortic valve development and disease.

Toomer KA, Fulmer D, Guo L, Drohan A, Peterson N, Swanson P, Brooks B, Mukherjee R, Body S, Lipschutz JH, Wessels A, Norris RA.

Dev Dyn. 2017 Aug;246(8):625-634. doi: 10.1002/dvdy.24524. Epub 2017 Jun 28.


The Dorsal Mesenchymal Protrusion and the Pathogenesis of Atrioventricular Septal Defects.

Burns T, Yang Y, Hiriart E, Wessels A.

J Cardiovasc Dev Dis. 2016 Dec;3(4). pii: 29. doi: 10.3390/jcdd3040029. Epub 2016 Sep 26.


Wnt/β-catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion.

Briggs LE, Burns TA, Lockhart MM, Phelps AL, Van den Hoff MJ, Wessels A.

Dev Dyn. 2016 Feb;245(2):103-13. doi: 10.1002/dvdy.24339. Epub 2015 Dec 29.


Mutations in DCHS1 cause mitral valve prolapse.

Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA.

Nature. 2015 Sep 3;525(7567):109-13. doi: 10.1038/nature14670. Epub 2015 Aug 10.


Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.

Dorr KM, Amin NM, Kuchenbrod LM, Labiner H, Charpentier MS, Pevny LH, Wessels A, Conlon FL.

Development. 2015 Jun 1;142(11):2037-47. doi: 10.1242/dev.119107. Epub 2015 May 7.


microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development.

Nagalakshmi VK, Lindner V, Wessels A, Yu J.

Dev Dyn. 2015 Mar;244(3):444-56. doi: 10.1002/dvdy.24221. Epub 2014 Nov 23.


Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction.

Lockhart MM, Boukens BJ, Phelps AL, Brown CL, Toomer KA, Burns TA, Mukherjee RD, Norris RA, Trusk TC, van den Hoff MJ, Wessels A.

Dev Biol. 2014 Dec 1;396(1):8-18. doi: 10.1016/j.ydbio.2014.09.031. Epub 2014 Oct 6.


The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart.

Lockhart MM, Phelps AL, van den Hoff MJ, Wessels A.

J Dev Biol. 2014 Mar 1;2(1):1-17.


Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation.

Briggs LE, Phelps AL, Brown E, Kakarla J, Anderson RH, van den Hoff MJ, Wessels A.

Circ Res. 2013 May 24;112(11):1420-32. doi: 10.1161/CIRCRESAHA.112.300821. Epub 2013 Apr 12.


Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.

Lockhart MM, Wirrig EE, Phelps AL, Ghatnekar AV, Barth JL, Norris RA, Wessels A.

PLoS One. 2013;8(2):e57073. doi: 10.1371/journal.pone.0057073. Epub 2013 Feb 26.


Developmental basis for filamin-A-associated myxomatous mitral valve disease.

Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA.

Cardiovasc Res. 2012 Oct 1;96(1):109-19. doi: 10.1093/cvr/cvs238. Epub 2012 Jul 25.


The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion.

Briggs LE, Kakarla J, Wessels A.

Differentiation. 2012 Jul;84(1):117-30. doi: 10.1016/j.diff.2012.05.006. Epub 2012 Jun 17. Review.


Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart.

Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB.

Dev Biol. 2012 Jun 15;366(2):111-24. doi: 10.1016/j.ydbio.2012.04.020. Epub 2012 Apr 24.


Progressive anatomical closure of foramen ovale in normal neonatal mouse hearts.

Cole-Jeffrey CT, Terada R, Neth MR, Wessels A, Kasahara H.

Anat Rec (Hoboken). 2012 May;295(5):764-8. doi: 10.1002/ar.22432. Epub 2012 Feb 21.


Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.

Dupuis LE, McCulloch DR, McGarity JD, Bahan A, Wessels A, Weber D, Diminich AM, Nelson CM, Apte SS, Kern CB.

Dev Biol. 2011 Sep 1;357(1):152-64. doi: 10.1016/j.ydbio.2011.06.041. Epub 2011 Jul 1.

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