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Co-transplantation of human adipose-derived mesenchymal stem cells with neonatal porcine islets within a prevascularized subcutaneous space augments the xenograft function.

Kuppan P, Seeberger K, Kelly S, Rosko M, Adesida A, Pepper AR, Korbutt GS.

Xenotransplantation. 2020 Jan 13:e12581. doi: 10.1111/xen.12581. [Epub ahead of print]


Co-localized immune protection using dexamethasone-eluting micelles in a murine islet allograft model.

Kuppan P, Kelly S, Polishevska K, Hojanepesov O, Seeberger K, Korbutt GS, Pepper AR.

Am J Transplant. 2020 Mar;20(3):714-725. doi: 10.1111/ajt.15662. Epub 2019 Nov 24.


Gap Balancing, Measured Resection, and Kinematic Alignment: How, When, and Why?

Mercuri JJ, Pepper AM, Werner JA, Vigdorchik JM.

JBJS Rev. 2019 Mar;7(3):e2. doi: 10.2106/JBJS.RVW.18.00026. No abstract available.


Age and Frailty Influence Hip and Knee Arthroplasty Reimbursement in a Bundled Payment Care Improvement Initiative.

Pepper AM, Novikov D, Cizmic Z, Barrett JT, Collins M, Iorio R, Schwarzkopf R, Long WJ.

J Arthroplasty. 2019 Jul;34(7S):S80-S83. doi: 10.1016/j.arth.2019.01.050. Epub 2019 Jan 30.


Total Hip and Knee Arthroplasty Perioperative Pain Management: What Should Be in the Cocktail.

Pepper AM, Mercuri JJ, Behery OA, Vigdorchik JM.

JBJS Rev. 2018 Dec;6(12):e5. doi: 10.2106/JBJS.RVW.18.00023. Review. No abstract available.


Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts.

Pepper AR, Bruni A, Pawlick R, O'Gorman D, Kin T, Thiesen A, Shapiro AMJ.

Diabetes. 2019 May;68(5):953-962. doi: 10.2337/db18-0788. Epub 2018 Nov 19.


Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells.

Gamble A, Pawlick R, Pepper AR, Bruni A, Adesida A, Senior PA, Korbutt GS, Shapiro AMJ.

PLoS One. 2018 Nov 12;13(11):e0206449. doi: 10.1371/journal.pone.0206449. eCollection 2018.


Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice.

Yu Y, Gamble A, Pawlick R, Pepper AR, Salama B, Toms D, Razian G, Ellis C, Bruni A, Gala-Lopez B, Lu JL, Vovko H, Chiu C, Abdo S, Kin T, Korbutt G, Shapiro AMJ, Ungrin M.

Diabetologia. 2018 Sep;61(9):2016-2029. doi: 10.1007/s00125-018-4672-5. Epub 2018 Jul 3.


Clinical islet transplantation: is the future finally now?

Pepper AR, Bruni A, Shapiro AMJ.

Curr Opin Organ Transplant. 2018 Aug;23(4):428-439. doi: 10.1097/MOT.0000000000000546. Review.


Ferroptosis-inducing agents compromise in vitro human islet viability and function.

Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble AF, Kin T, Seeberger K, Korbutt GS, Bornstein SR, Linkermann A, Shapiro AMJ.

Cell Death Dis. 2018 May 22;9(6):595. doi: 10.1038/s41419-018-0506-0.


BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model.

Bruni A, Pepper AR, Pawlick RL, Gala-Lopez B, Gamble A, Kin T, Malcolm AJ, Jones C, Piganelli JD, Crapo JD, Shapiro AMJ.

Am J Transplant. 2018 Aug;18(8):1879-1889. doi: 10.1111/ajt.14705. Epub 2018 Mar 31.


The journey of islet cell transplantation and future development.

Gamble A, Pepper AR, Bruni A, Shapiro AMJ.

Islets. 2018 Mar 4;10(2):80-94. doi: 10.1080/19382014.2018.1428511. Epub 2018 Feb 5. Review.


Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation.

Gala-Lopez BL, Neiman D, Kin T, O'Gorman D, Pepper AR, Malcolm AJ, Pianzin S, Senior PA, Campbell P, Glaser B, Dor Y, Shemer R, Shapiro AMJ.

Transplantation. 2018 Jun;102(6):978-985. doi: 10.1097/TP.0000000000002083.


Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations.

Pawlick R, Gala-Lopez B, Pepper AR, Abualhassan N, Bruni A, Suzuki K, Rayat G, Elliott JF, Shapiro AMJ.

Islets. 2017 Jul 4;9(4):e1330742. doi: 10.1080/19382014.2017.1330742. Epub 2017 Jul 10.


Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.

Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O'Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ.

Stem Cell Reports. 2017 Jun 6;8(6):1689-1700. doi: 10.1016/j.stemcr.2017.05.004.


Engraftment Site and Effectiveness of the Pan-Caspase Inhibitor F573 to Improve Engraftment in Mouse and Human Islet Transplantation in Mice.

Pepper AR, Bruni A, Pawlick R, Wink J, Rafiei Y, Gala-Lopez B, Bral M, Abualhassan N, Kin T, Shapiro AMJ.

Transplantation. 2017 Oct;101(10):2321-2329. doi: 10.1097/TP.0000000000001638.


Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site.

Pepper AR, Bruni A, Pawlick RL, Gala-Lopez B, Rafiei Y, Wink J, Kin T, Shapiro AM.

Islets. 2016 Nov;8(6):186-194. Epub 2016 Nov 7.


Intraoperative Hypothermia in Total Hip and Knee Arthroplasty.

Frisch NB, Pepper AM, Rooney E, Silverton C.

Orthopedics. 2017 Jan 1;40(1):56-63. doi: 10.3928/01477447-20161017-04. Epub 2016 Oct 27.


Intraoperative Hypothermia During Surgical Fixation of Hip Fractures.

Frisch NB, Pepper AM, Jildeh TR, Shaw J, Guthrie T, Silverton C.

Orthopedics. 2016 Nov 1;39(6):e1170-e1177. doi: 10.3928/01477447-20160811-04. Epub 2016 Aug 18.


Reparixin, a CXCR1/2 inhibitor in islet allotransplantation.

Pawlick RL, Wink J, Pepper AR, Bruni A, Abualhassen N, Rafiei Y, Gala-Lopez B, Bral M, Shapiro AM.

Islets. 2016 Sep 2;8(5):115-24. doi: 10.1080/19382014.2016.1199303. Epub 2016 Jun 21.

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