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Items: 1 to 20 of 36


Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons.

Metrick MA 2nd, do Carmo Ferreira N, Saijo E, Hughson AG, Kraus A, Orrú C, Miller MW, Zanusso G, Ghetti B, Vendruscolo M, Caughey B.

Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23029-23039. doi: 10.1073/pnas.1909322116. Epub 2019 Oct 22.


Inactivation of chronic wasting disease prions using sodium hypochlorite.

Williams K, Hughson AG, Chesebro B, Race B.

PLoS One. 2019 Oct 4;14(10):e0223659. doi: 10.1371/journal.pone.0223659. eCollection 2019.


Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates.

Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B.

Methods Mol Biol. 2019;1873:19-37. doi: 10.1007/978-1-4939-8820-4_2.


Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques.

Race B, Williams K, Orrú CD, Hughson AG, Lubke L, Chesebro B.

J Virol. 2018 Jun 29;92(14). pii: e00550-18. doi: 10.1128/JVI.00550-18. Print 2018 Jul 15.


Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein.

Race B, Williams K, Hughson AG, Jansen C, Parchi P, Rozemuller AJM, Chesebro B.

Acta Neuropathol Commun. 2018 Feb 20;6(1):13. doi: 10.1186/s40478-018-0516-2.


Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B.

Acta Neuropathol Commun. 2018 Feb 9;6(1):7. doi: 10.1186/s40478-018-0508-2.


Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.

Groveman BR, Raymond GJ, Campbell KJ, Race B, Raymond LD, Hughson AG, Orrú CD, Kraus A, Phillips K, Caughey B.

PLoS Pathog. 2017 Sep 14;13(9):e1006623. doi: 10.1371/journal.ppat.1006623. eCollection 2017 Sep.


High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions.

Franceschini A, Baiardi S, Hughson AG, McKenzie N, Moda F, Rossi M, Capellari S, Green A, Giaccone G, Caughey B, Parchi P.

Sci Rep. 2017 Sep 6;7(1):10655. doi: 10.1038/s41598-017-10922-w.


RT-QuIC Assays for Prion Disease Detection and Diagnostics.

Orrù CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Campbell KJ, Anson KJ, Kraus A, Caughey B.

Methods Mol Biol. 2017;1658:185-203. doi: 10.1007/978-1-4939-7244-9_14.


Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants.

Caughey B, Orru CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Race B, Saijo E, Kraus A.

Prog Mol Biol Transl Sci. 2017;150:375-388. doi: 10.1016/bs.pmbts.2017.06.003. Epub 2017 Jul 27. Review.


PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions.

Kraus A, Raymond GJ, Race B, Campbell KJ, Hughson AG, Anson KJ, Raymond LD, Caughey B.

J Virol. 2017 Oct 13;91(21). pii: e01276-17. doi: 10.1128/JVI.01276-17. Print 2017 Nov 1.


Extended and direct evaluation of RT-QuIC assays for Creutzfeldt-Jakob disease diagnosis.

Groveman BR, Orrú CD, Hughson AG, Bongianni M, Fiorini M, Imperiale D, Ladogana A, Pocchiari M, Zanusso G, Caughey B.

Ann Clin Transl Neurol. 2016 Dec 27;4(2):139-144. doi: 10.1002/acn3.378. eCollection 2017 Feb.


Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples.

Bongianni M, Orrù C, Groveman BR, Sacchetto L, Fiorini M, Tonoli G, Triva G, Capaldi S, Testi S, Ferrari S, Cagnin A, Ladogana A, Poleggi A, Colaizzo E, Tiple D, Vaianella L, Castriciano S, Marchioni D, Hughson AG, Imperiale D, Cattaruzza T, Fabrizi GM, Pocchiari M, Monaco S, Caughey B, Zanusso G.

JAMA Neurol. 2017 Feb 1;74(2):155-162. doi: 10.1001/jamaneurol.2016.4614.


Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid.

Hughson AG, Race B, Kraus A, Sangaré LR, Robins L, Groveman BR, Saijo E, Phillips K, Contreras L, Dhaliwal V, Manca M, Zanusso G, Terry D, Williams JF, Caughey B.

PLoS Pathog. 2016 Sep 29;12(9):e1005914. doi: 10.1371/journal.ppat.1005914. eCollection 2016 Sep.


Factors That Improve RT-QuIC Detection of Prion Seeding Activity.

Orrú CD, Hughson AG, Groveman BR, Campbell KJ, Anson KJ, Manca M, Kraus A, Caughey B.

Viruses. 2016 May 23;8(5). pii: E140. doi: 10.3390/v8050140.


Correction for Masujin et al., Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.

Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B.

J Clin Microbiol. 2016 May;54(5):1407. doi: 10.1128/JCM.00472-16. No abstract available.


PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.

Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, Caughey B.

J Virol. 2016 Apr 29;90(10):4905-4913. doi: 10.1128/JVI.00088-16. Print 2016 May 15.


Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.

Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B.

J Clin Microbiol. 2016 Mar;54(3):676-86. doi: 10.1128/JCM.02731-15. Epub 2016 Jan 6. Erratum in: J Clin Microbiol. 2016 May;54(5):1407.


Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.

Dassanayake RP, Orrú CD, Hughson AG, Caughey B, Graça T, Zhuang D, Madsen-Bouterse SA, Knowles DP, Schneider DA.

J Gen Virol. 2016 Mar;97(3):803-812. doi: 10.1099/jgv.0.000367. Epub 2015 Dec 10.


Correction: Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B.

PLoS Pathog. 2015 Aug 18;11(8):e1005117. doi: 10.1371/journal.ppat.1005117. eCollection 2015 Aug. No abstract available.

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