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Items: 1 to 20 of 55

2.

Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis.

Thorenz A, Derlin K, Schröder C, Dressler L, Vijayan V, Pradhan P, Immenschuh S, Jörns A, Echtermeyer F, Herzog C, Chen R, Rong S, Bräsen JH, van Kooten C, Kirsch T, Klemann C, Meier M, Klos A, Haller H, Hensen B, Gueler F.

Kidney Int. 2018 Oct;94(4):741-755. doi: 10.1016/j.kint.2018.04.005. Epub 2018 Jun 21.

PMID:
29935951
3.

Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection.

Rother M, Gonzalez E, Teixeira da Costa AR, Wask L, Gravenstein I, Pardo M, Pietzke M, Gurumurthy RK, Angermann J, Laudeley R, Glage S, Meyer M, Chumduri C, Kempa S, Dinkel K, Unger A, Klebl B, Klos A, Meyer TF.

Cell Host Microbe. 2018 May 9;23(5):661-671.e8. doi: 10.1016/j.chom.2018.04.002. Epub 2018 Apr 26.

4.

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO.

MBio. 2018 Jan 23;9(1). pii: e01755-17. doi: 10.1128/mBio.01755-17.

5.

The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments.

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF.

Mol Immunol. 2018 Jan;93:266-277. doi: 10.1016/j.molimm.2017.07.010. Epub 2017 Aug 30.

PMID:
28860090
6.

Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections.

Weiss E, Hanzelmann D, Fehlhaber B, Klos A, von Loewenich FD, Liese J, Peschel A, Kretschmer D.

FASEB J. 2018 Jan;32(1):26-36. doi: 10.1096/fj.201700441R. Epub 2017 Aug 30.

7.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

8.

An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions.

Dutow P, Wask L, Bothe M, Fehlhaber B, Laudeley R, Rheinheimer C, Yang Z, Zhong G, Glage S, Klos A.

Pathog Dis. 2016 Mar;74(2). pii: ftv120. doi: 10.1093/femspd/ftv120. Epub 2015 Dec 15.

PMID:
26676260
9.

Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection.

Horst SA, Itzek A, Klos A, Beineke A, Medina E.

Pathogens. 2015 Oct 23;4(4):722-38. doi: 10.3390/pathogens4040722.

10.

Severe pneumonia due to Parachlamydia acanthamoebae following intranasal inoculation: a mice model.

Pilloux L, Casson N, Sommer K, Klos A, Stehle JC, Pusztaszeri M, Greub G.

Microbes Infect. 2015 Nov-Dec;17(11-12):755-60. doi: 10.1016/j.micinf.2015.08.007. Epub 2015 Sep 1.

11.

Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice.

Selle J, Asare Y, Köhncke J, Alampour-Rajabi S, Shagdarsuren G, Klos A, Weber C, Jankowski J, Shagdarsuren E.

Thromb Haemost. 2015 Oct;114(4):848-58. doi: 10.1160/TH14-12-1075. Epub 2015 Jun 18.

PMID:
26084965
12.

Temperature and host cell-dependent changes in virulence of Chlamydia pneumoniae CWL029 in an optimized mouse infection model.

Janik K, Bode J, Dutow P, Laudeley R, Geffers R, Sommer K, Glage S, Klos A.

Pathog Dis. 2015 Feb;73(1):1-8. doi: 10.1093/femspd/ftu001. Epub 2014 Dec 4.

PMID:
25853997
13.

DXD motif-dependent and -independent effects of the chlamydia trachomatis cytotoxin CT166.

Bothe M, Dutow P, Pich A, Genth H, Klos A.

Toxins (Basel). 2015 Feb 17;7(2):621-37. doi: 10.3390/toxins7020621.

14.

Chlamydia psittaci: new insights into genomic diversity, clinical pathology, host-pathogen interaction and anti-bacterial immunity.

Knittler MR, Berndt A, Böcker S, Dutow P, Hänel F, Heuer D, Kägebein D, Klos A, Koch S, Liebler-Tenorio E, Ostermann C, Reinhold P, Saluz HP, Schöfl G, Sehnert P, Sachse K.

Int J Med Microbiol. 2014 Oct;304(7):877-93. doi: 10.1016/j.ijmm.2014.06.010. Epub 2014 Jun 28. Review.

15.

Structural and functional characterization of human and murine C5a anaphylatoxins.

Schatz-Jakobsen JA, Yatime L, Larsen C, Petersen SV, Klos A, Andersen GR.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1704-17. doi: 10.1107/S139900471400844X. Epub 2014 May 30.

16.

Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum.

Yang Z, Conrad T, Zhou Z, Chen J, Dutow P, Klos A, Zhong G.

Infect Immun. 2014 Aug;82(8):3154-63. doi: 10.1128/IAI.01833-14. Epub 2014 May 19.

17.

C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β-arrestin recruitment.

Croker DE, Halai R, Kaeslin G, Wende E, Fehlhaber B, Klos A, Monk PN, Cooper MA.

Immunol Cell Biol. 2014 Aug;92(7):631-9. doi: 10.1038/icb.2014.32. Epub 2014 Apr 29.

18.

Role of capsule and suilysin in mucosal infection of complement-deficient mice with Streptococcus suis.

Seitz M, Beineke A, Singpiel A, Willenborg J, Dutow P, Goethe R, Valentin-Weigand P, Klos A, Baums CG.

Infect Immun. 2014 Jun;82(6):2460-71. doi: 10.1128/IAI.00080-14. Epub 2014 Mar 31.

19.

Histamine induces chemotaxis and phagocytosis in murine bone marrow-derived macrophages and RAW 264.7 macrophage-like cells via histamine H4-receptor.

Czerner CP, Klos A, Seifert R, Neumann D.

Inflamm Res. 2014 Mar;63(3):239-47. doi: 10.1007/s00011-013-0694-0. Epub 2013 Dec 8.

PMID:
24316866
20.

The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response.

Dutow P, Fehlhaber B, Bode J, Laudeley R, Rheinheimer C, Glage S, Wetsel RA, Pabst O, Klos A.

J Infect Dis. 2014 Apr 15;209(8):1269-78. doi: 10.1093/infdis/jit640. Epub 2013 Nov 23.

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