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Items: 1 to 20 of 30


Vampire Venom: Vasodilatory Mechanisms of Vampire Bat (Desmodus rotundus) Blood Feeding.

Kakumanu R, Hodgson WC, Ravi R, Alagon A, Harris RJ, Brust A, Alewood PF, Kemp-Harper BK, Fry BG.

Toxins (Basel). 2019 Jan 8;11(1). pii: E26. doi: 10.3390/toxins11010026.


Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.


Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation.

Ikonomopoulou MP, Fernandez-Rojo MA, Pineda SS, Cabezas-Sainz P, Winnen B, Morales RAV, Brust A, Sánchez L, Alewood PF, Ramm GA, Miles JJ, King GF.

Sci Rep. 2018 Aug 1;8(1):11519. doi: 10.1038/s41598-018-29826-4.


Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter.

Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5203. doi: 10.1002/anie.201803138. No abstract available.


Gomesin peptides prevent proliferation and lead to the cell death of devil facial tumour disease cells.

Fernandez-Rojo MA, Deplazes E, Pineda SS, Brust A, Marth T, Wilhelm P, Martel N, Ramm GA, Mancera RL, Alewood PF, Woods GM, Belov K, Miles JJ, King GF, Ikonomopoulou MP.

Cell Death Discov. 2018 Feb 14;4:19. doi: 10.1038/s41420-018-0030-0. eCollection 2018 Dec.


Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.

Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ.

PLoS One. 2017 Sep 7;12(9):e0182848. doi: 10.1371/journal.pone.0182848. eCollection 2017.


Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.

Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ.

Sci Rep. 2017 Mar 31;7:45466. doi: 10.1038/srep45466.


The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus).

Yang DC, Deuis JR, Dashevsky D, Dobson J, Jackson TN, Brust A, Xie B, Koludarov I, Debono J, Hendrikx I, Hodgson WC, Josh P, Nouwens A, Baillie GJ, Bruxner TJ, Alewood PF, Lim KK, Frank N, Vetter I, Fry BG.

Toxins (Basel). 2016 Oct 18;8(10). pii: E303.


Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.

Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562. doi: 10.1016/j.bbagen.2016.07.027. Epub 2016 Jul 28.


Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers.

Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF.

J Pept Sci. 2016 May;22(5):280-9. doi: 10.1002/psc.2857. Epub 2016 Feb 22.


Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

Brust A, Croker DE, Colless B, Ragnarsson L, Andersson Å, Jain K, Garcia-Caraballo S, Castro J, Brierley SM, Alewood PF, Lewis RJ.

J Med Chem. 2016 Mar 24;59(6):2381-95. doi: 10.1021/acs.jmedchem.5b00911. Epub 2016 Feb 22.


Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia.

Deuis JR, Whately E, Brust A, Inserra MC, Asvadi NH, Lewis RJ, Alewood PF, Cabot PJ, Vetter I.

ACS Chem Neurosci. 2015 Oct 21;6(10):1751-8. doi: 10.1021/acschemneuro.5b00113. Epub 2015 Aug 12.


A defined α-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus.

Reeks T, Jones A, Brust A, Sridharan S, Corcilius L, Wilkinson BL, Thaysen-Andersen M, Payne RJ, Kini RM, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4828-31. doi: 10.1002/anie.201411914. Epub 2015 Mar 3.


Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic.

Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A.

Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1361-4. doi: 10.1002/anie.201409678. Epub 2014 Dec 5.


Cone snail venomics: from novel biology to novel therapeutics.

Prashanth JR, Brust A, Jin AH, Alewood PF, Dutertre S, Lewis RJ.

Future Med Chem. 2014 Oct;6(15):1659-75. doi: 10.4155/fmc.14.99. Review. Erratum in: Future Med Chem. 2014;6(18):2134.


Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.

Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD.

J Med Chem. 2014 Nov 13;57(21):9195-203. doi: 10.1021/jm501400p. Epub 2014 Nov 4.


High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage.

Brust A, Schroeder CI, Alewood PF.

ChemMedChem. 2014 May;9(5):1038-46. doi: 10.1002/cmdc.201300524. Epub 2014 Mar 3.


Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter.

Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12020-3. doi: 10.1002/anie.201304660. Epub 2013 Sep 24. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2018 May 4;57(19):5203.


Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors.

Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ.

J Biol Chem. 2013 Nov 29;288(48):34428-42. doi: 10.1074/jbc.M113.512582. Epub 2013 Oct 7.


Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors.

Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ.

Biochem Pharmacol. 2013 Sep 15;86(6):791-9. doi: 10.1016/j.bcp.2013.07.016. Epub 2013 Aug 4.


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