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Items: 1 to 20 of 42

1.

Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds.

Lenci E, Innocenti R, Di Francescantonio T, Menchi G, Bianchini F, Contini A, Trabocchi A.

Bioorg Med Chem. 2019 May 1;27(9):1891-1902. doi: 10.1016/j.bmc.2019.03.043. Epub 2019 Mar 22.

PMID:
30926311
2.

Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis.

Lenci E, Menchi G, Saldívar-Gonzalez FI, Medina-Franco JL, Trabocchi A.

Org Biomol Chem. 2019 Jan 31;17(5):1037-1052. doi: 10.1039/c8ob02808g. Review.

PMID:
30620036
3.

Smart Design of Small-Molecule Libraries: When Organic Synthesis Meets Cheminformatics.

Lenci E, Trabocchi A.

Chembiochem. 2019 May 2;20(9):1115-1123. doi: 10.1002/cbic.201800751. Epub 2019 Mar 19. Review.

PMID:
30589187
4.

Diversity-Oriented Synthesis and Chemoinformatic Analysis of the Molecular Diversity of sp3-Rich Morpholine Peptidomimetics.

Lenci E, Innocenti R, Menchi G, Trabocchi A.

Front Chem. 2018 Oct 30;6:522. doi: 10.3389/fchem.2018.00522. eCollection 2018.

5.

Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle.

Stefanini I, Rizzetto L, Rivero D, Carbonell S, Gut M, Heath S, Gut IG, Trabocchi A, Guarna A, Ben Ghazzi N, Bowyer P, Kapushesky M, Cavalieri D.

Sci Rep. 2018 Apr 13;8(1):5964. doi: 10.1038/s41598-018-24341-y.

6.

Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds.

Lenci E, Rossi A, Menchi G, Trabocchi A.

Org Biomol Chem. 2017 Nov 22;15(45):9710-9717. doi: 10.1039/c7ob02454a.

PMID:
29125175
7.

Corrigendum to "Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors" [Bioorg. Med. Chem. 25 (2017) 5077-5083].

Innocenti R, Lenci E, Menchi G, Pupi A, Trabocchi A.

Bioorg Med Chem. 2017 Dec 15;25(24):6724-6725. doi: 10.1016/j.bmc.2017.10.019. Epub 2017 Nov 1. No abstract available.

PMID:
29111366
8.

Design and synthesis of bioactive compounds.

Trabocchi A.

Bioorg Med Chem. 2017 Oct 1;25(19):5031. doi: 10.1016/j.bmc.2017.09.020. No abstract available.

PMID:
28950983
9.

Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae.

Brilli M, Trabocchi A, Weil T, Cavalieri D, Stefanini I.

Front Pharmacol. 2017 Mar 30;8:170. doi: 10.3389/fphar.2017.00170. eCollection 2017.

10.

Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors.

Innocenti R, Lenci E, Menchi G, Pupi A, Trabocchi A.

Bioorg Med Chem. 2017 Oct 1;25(19):5077-5083. doi: 10.1016/j.bmc.2017.03.030. Epub 2017 Mar 18. Erratum in: Bioorg Med Chem. 2017 Dec 15;25(24):6724-6725.

PMID:
28359674
11.

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.

Lenci E, Innocenti R, Biagioni A, Menchi G, Bianchini F, Trabocchi A.

Molecules. 2016 Oct 20;21(10). pii: E1405.

12.

Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells.

Bianchini F, Peppicelli S, Fabbrizzi P, Biagioni A, Mazzanti B, Menchi G, Calorini L, Pupi A, Trabocchi A.

Mol Cell Biochem. 2017 Jan;424(1-2):99-110. doi: 10.1007/s11010-016-2847-2. Epub 2016 Oct 19.

13.

Insight to the binding mode of triazole RGD-peptidomimetics to integrin-rich cancer cells by NMR and molecular modeling.

Vasile F, Menchi G, Lenci E, Guarna A, Potenza D, Trabocchi A.

Bioorg Med Chem. 2016 Mar 1;24(5):989-94. doi: 10.1016/j.bmc.2016.01.023. Epub 2016 Jan 14.

PMID:
26818999
14.

Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands.

Sernissi L, Trabocchi A, Scarpi D, Bianchini F, Occhiato EG.

Bioorg Med Chem. 2016 Feb 15;24(4):703-11. doi: 10.1016/j.bmc.2015.12.039. Epub 2015 Dec 24.

PMID:
26753814
15.

Two-step one-pot synthesis of dihydropyrazinones as Xaa-Ser dipeptide isosteres through morpholine acetal rearrangement.

Lenci E, Innocenti R, Menchi G, Faggi C, Trabocchi A.

Org Biomol Chem. 2015 Jul 7;13(25):7013-9. doi: 10.1039/c5ob00783f. Epub 2015 Jun 1.

PMID:
26030011
16.

Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis.

Bianchini F, Fabbrizzi P, Menchi G, Raspanti S, Bottoncetti A, Passeri A, Andreucci E, Guarna A, Calorini L, Pupi A, Trabocchi A.

Bioorg Med Chem. 2015 Mar 1;23(5):1112-22. doi: 10.1016/j.bmc.2014.12.065. Epub 2015 Jan 13.

PMID:
25637121
17.

Skeletal diversity from carbohydrates: use of mannose for the diversity-oriented synthesis of polyhydroxylated compounds.

Lenci E, Menchi G, Guarna A, Trabocchi A.

J Org Chem. 2015 Feb 20;80(4):2182-91. doi: 10.1021/jo502701c. Epub 2015 Feb 11.

PMID:
25636147
18.

Diversity-oriented synthesis as a tool for chemical genetics.

Lenci E, Guarna A, Trabocchi A.

Molecules. 2014 Oct 14;19(10):16506-28. doi: 10.3390/molecules191016506. Review.

19.

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.

Trabocchi A, Pala N, Krimmelbein I, Menchi G, Guarna A, Sechi M, Dreker T, Scozzafava A, Supuran CT, Carta F.

J Enzyme Inhib Med Chem. 2015 Jun;30(3):466-71. doi: 10.3109/14756366.2014.947976. Epub 2014 Sep 8.

PMID:
25198885
20.

Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics: application in the synthesis of an Arg-Gly-Asp (RGD)-containing peptide as an αvβ3 integrin ligand.

Sernissi L, Petrović M, Scarpi D, Guarna A, Trabocchi A, Bianchini F, Occhiato EG.

Chemistry. 2014 Aug 25;20(35):11187-203. doi: 10.1002/chem.201403077. Epub 2014 Jul 28.

PMID:
25069617

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