Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 52

1.

Structural model for differential cap maturation at growing microtubule ends.

Estévez-Gallego J, Josa-Prado F, Ku S, Buey RM, Balaguer FA, Prota AE, Lucena-Agell D, Kamma-Lorger C, Yagi T, Iwamoto H, Duchesne L, Barasoain I, Steinmetz MO, Chrétien D, Kamimura S, Díaz JF, Oliva MA.

Elife. 2020 Mar 10;9. pii: e50155. doi: 10.7554/eLife.50155.

2.

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.

Cury NM, Mühlethaler T, Laranjeira ABA, Canevarolo RR, Zenatti PP, Lucena-Agell D, Barasoain I, Song C, Sun D, Dovat S, Yunes RA, Prota AE, Steinmetz MO, Díaz JF, Yunes JA.

iScience. 2019 Nov 22;21:95-109. doi: 10.1016/j.isci.2019.10.003. Epub 2019 Oct 2.

3.

Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex.

Faltova L, Jiang K, Frey D, Wu Y, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, Kammerer RA.

Structure. 2019 Sep 3;27(9):1375-1383.e3. doi: 10.1016/j.str.2019.07.002. Epub 2019 Jul 25.

PMID:
31353241
4.

VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.

Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB.

Cell Syst. 2019 Jul 24;9(1):74-92.e8. doi: 10.1016/j.cels.2019.05.009. Epub 2019 Jul 10.

5.

Alternative folding to a monomer or homopolymer is a common feature of the type 1 pilus subunit FimA from enteroinvasive bacteria.

Żyła DS, Prota AE, Capitani G, Glockshuber R.

J Biol Chem. 2019 Jul 5;294(27):10553-10563. doi: 10.1074/jbc.RA119.008610. Epub 2019 May 24.

6.

Comparative Analysis of Existing RC Columns Jacketed with CFRP or FRCC.

Del Zoppo M, Di Ludovico M, Balsamo A, Prota A.

Polymers (Basel). 2018 Mar 24;10(4). pii: E361. doi: 10.3390/polym10040361.

7.

Numerical Investigation of Masonry Strengthened with Composites.

Ramaglia G, Lignola GP, Fabbrocino F, Prota A.

Polymers (Basel). 2018 Mar 19;10(3). pii: E334. doi: 10.3390/polym10030334.

8.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF.

Int J Mol Sci. 2019 Mar 20;20(6). pii: E1392. doi: 10.3390/ijms20061392.

9.

Conformational Properties of the Chemotherapeutic Drug Analogue Epothilone A: How to Model a Flexible Protein Ligand Using Scarcely Available Experimental Data.

Dolenc J, van Gunsteren WF, Prota AE, Steinmetz MO, Missimer JH.

J Chem Inf Model. 2019 May 28;59(5):2218-2230. doi: 10.1021/acs.jcim.9b00171. Epub 2019 Mar 25.

PMID:
30855963
10.

Unified Theory for Flexural Strengthening of Masonry with Composites.

Ramaglia G, Fabbrocino F, Lignola GP, Prota A.

Materials (Basel). 2019 Feb 25;12(4). pii: E680. doi: 10.3390/ma12040680.

11.

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocrystal Structure.

Dohle W, Prota AE, Menchon G, Hamel E, Steinmetz MO, Potter BVL.

ACS Omega. 2019 Jan 31;4(1):755-764. doi: 10.1021/acsomega.8b02879. Epub 2019 Jan 9.

12.

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, Conte M, Lopresti L, Magnano S, Amet R, Kinsella P, Zisterer DM, Ibrahim O, O'Sullivan J, Morbidelli L, Spaccapelo R, Baldari C, Butini S, Novellino E, Campiani G, Altucci L, Steinmetz MO, Brogi S.

Eur J Med Chem. 2019 Jan 15;162:290-320. doi: 10.1016/j.ejmech.2018.11.004. Epub 2018 Nov 3.

PMID:
30448418
13.

Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim KH, Kam TS, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, Moses JE.

Sci Rep. 2018 Jul 13;8(1):10617. doi: 10.1038/s41598-018-28880-2.

14.

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton.

Steinmetz MO, Prota AE.

Trends Cell Biol. 2018 Oct;28(10):776-792. doi: 10.1016/j.tcb.2018.05.001. Epub 2018 Jun 2. Review.

PMID:
29871823
15.

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.

Menchon G, Prota AE, Lucena-Agell D, Bucher P, Jansen R, Irschik H, Müller R, Paterson I, Díaz JF, Altmann KH, Steinmetz MO.

Nat Commun. 2018 May 29;9(1):2106. doi: 10.1038/s41467-018-04535-8.

16.

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.

Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM.

Sci Rep. 2018 Mar 9;8(1):4242. doi: 10.1038/s41598-018-22382-x.

17.

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Jiang K, Faltova L, Hua S, Capitani G, Prota AE, Landgraf C, Volkmer R, Kammerer RA, Steinmetz MO, Akhmanova A.

Structure. 2018 Mar 6;26(3):375-382.e4. doi: 10.1016/j.str.2017.12.017. Epub 2018 Jan 26.

18.

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure.

Dohle W, Jourdan FL, Menchon G, Prota AE, Foster PA, Mannion P, Hamel E, Thomas MP, Kasprzyk PG, Ferrandis E, Steinmetz MO, Leese MP, Potter BVL.

J Med Chem. 2018 Feb 8;61(3):1031-1044. doi: 10.1021/acs.jmedchem.7b01474. Epub 2018 Jan 8.

PMID:
29227648
19.

Structural basis of katanin p60:p80 complex formation.

Rezabkova L, Jiang K, Capitani G, Prota AE, Akhmanova A, Steinmetz MO, Kammerer RA.

Sci Rep. 2017 Nov 2;7(1):14893. doi: 10.1038/s41598-017-14194-2.

20.

Zampanolide Binding to Tubulin Indicates Cross-Talk of Taxane Site with Colchicine and Nucleotide Sites.

Field JJ, Pera B, Gallego JE, Calvo E, Rodríguez-Salarichs J, Sáez-Calvo G, Zuwerra D, Jordi M, Andreu JM, Prota AE, Ménchon G, Miller JH, Altmann KH, Díaz JF.

J Nat Prod. 2018 Mar 23;81(3):494-505. doi: 10.1021/acs.jnatprod.7b00704. Epub 2017 Oct 12.

PMID:
29023132

Supplemental Content

Loading ...
Support Center