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Items: 20

1.

EMMA assembly explained: A step-by-step guide to assemble synthetic mammalian vectors.

Jones S, Martella A, Cai Y.

Methods Enzymol. 2019;617:463-493. doi: 10.1016/bs.mie.2018.12.017. Epub 2019 Feb 13.

PMID:
30784414
2.

In Silico Identification and Experimental Validation of (-)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator.

D'Aniello E, Iannotti FA, Falkenberg LG, Martella A, Gentile A, De Maio F, Ciavatta ML, Gavagnin M, Waxman JS, Di Marzo V, Amodeo P, Vitale RM.

Mar Drugs. 2019 Feb 12;17(2). pii: E110. doi: 10.3390/md17020110.

3.

Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI.

Zhou J, Mock ED, Martella A, Kantae V, Di X, Burggraaff L, Baggelaar MP, Al-Ayed K, Bakker A, Florea BI, Grimm SH, den Dulk H, Li CT, Mulder L, Overkleeft HS, Hankemeier T, van Westen GJP, van der Stelt M.

ACS Chem Biol. 2019 Feb 15;14(2):164-169. doi: 10.1021/acschembio.8b00969. Epub 2019 Jan 18.

4.

Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest.

Vitale RM, D'Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani ME, Fellous T, Gentile A, Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D'Aniello B, Defranoux F, Felline S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E.

Mar Drugs. 2018 Nov 3;16(11). pii: E431. doi: 10.3390/md16110431.

5.

Δ9-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6.

Janssens A, Silvestri C, Martella A, Vanoevelen JM, Di Marzo V, Voets T.

Pharmacol Res. 2018 Oct;136:83-89. doi: 10.1016/j.phrs.2018.08.021. Epub 2018 Aug 28.

PMID:
30170189
6.

Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time.

Soethoudt M, Hoorens MWH, Doelman W, Martella A, van der Stelt M, Heitman LH.

Biochem Pharmacol. 2018 Jun;152:129-142. doi: 10.1016/j.bcp.2018.03.018. Epub 2018 Mar 21.

7.

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

Soethoudt M, Stolze SC, Westphal MV, van Stralen L, Martella A, van Rooden EJ, Guba W, Varga ZV, Deng H, van Kasteren SI, Grether U, IJzerman AP, Pacher P, Carreira EM, Overkleeft HS, Ioan-Facsinay A, Heitman LH, van der Stelt M.

J Am Chem Soc. 2018 May 16;140(19):6067-6075. doi: 10.1021/jacs.7b11281. Epub 2018 Feb 16.

8.

A Novel Selective Inverse Agonist of the CB2 Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies.

Martella A, Sijben H, Rufer AC, Grether U, Fingerle J, Ullmer C, Hartung T, IJzerman AP, van der Stelt M, Heitman LH.

Mol Pharmacol. 2017 Oct;92(4):389-400. doi: 10.1124/mol.117.108605. Epub 2017 Jul 26.

PMID:
28747489
9.

EMMA: An Extensible Mammalian Modular Assembly Toolkit for the Rapid Design and Production of Diverse Expression Vectors.

Martella A, Matjusaitis M, Auxillos J, Pollard SM, Cai Y.

ACS Synth Biol. 2017 Jul 21;6(7):1380-1392. doi: 10.1021/acssynbio.7b00016. Epub 2017 Apr 24.

PMID:
28418644
10.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

11.

Mammalian Synthetic Biology: Time for Big MACs.

Martella A, Pollard SM, Dai J, Cai Y.

ACS Synth Biol. 2016 Oct 21;5(10):1040-1049. Epub 2016 Apr 20. Review.

12.

Important role of endocannabinoid signaling in the development of functional vision and locomotion in zebrafish.

Martella A, Sepe RM, Silvestri C, Zang J, Fasano G, Carnevali O, De Girolamo P, Neuhauss SC, Sordino P, Di Marzo V.

FASEB J. 2016 Dec;30(12):4275-4288. Epub 2016 Sep 13.

PMID:
27623930
13.

Bisphenol A Induces Fatty Liver by an Endocannabinoid-Mediated Positive Feedback Loop.

Martella A, Silvestri C, Maradonna F, Gioacchini G, Allarà M, Radaelli G, Overby DR, Di Marzo V, Carnevali O.

Endocrinology. 2016 May;157(5):1751-63. doi: 10.1210/en.2015-1384. Epub 2016 Mar 25.

14.

Negative Regulation of Leptin-induced Reactive Oxygen Species (ROS) Formation by Cannabinoid CB1 Receptor Activation in Hypothalamic Neurons.

Palomba L, Silvestri C, Imperatore R, Morello G, Piscitelli F, Martella A, Cristino L, Di Marzo V.

J Biol Chem. 2015 May 29;290(22):13669-77. doi: 10.1074/jbc.M115.646885. Epub 2015 Apr 13.

15.

A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.

Gu W, Monteiro R, Zuo J, Simões FC, Martella A, Andrieu-Soler C, Grosveld F, Sauka-Spengler T, Patient R.

PLoS Biol. 2015 Feb 9;13(2):e1002051. doi: 10.1371/journal.pbio.1002051. eCollection 2015 Feb.

16.

Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis.

Silvestri C, Paris D, Martella A, Melck D, Guadagnino I, Cawthorne M, Motta A, Di Marzo V.

J Hepatol. 2015 Jun;62(6):1382-90. doi: 10.1016/j.jhep.2015.01.001. Epub 2015 Jan 13.

PMID:
25595882
17.

The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels.

Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Bíró T, Harkany T, Taglialatela M, Di Marzo V.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2472-81. doi: 10.1073/pnas.1406728111. Epub 2014 Jun 3.

18.

Molecular analysis of endocrine disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species microarray.

Baker ME, Vidal-Dorsch DE, Ribecco C, Sprague LJ, Angert M, Lekmine N, Ludka C, Martella A, Ricciardelli E, Bay SM, Gully JR, Kelley KM, Schlenk D, Carnevali O, Šášik R, Hardiman G.

PLoS One. 2013 Sep 25;8(9):e75553. doi: 10.1371/journal.pone.0075553. eCollection 2013.

19.

Anandamide-derived prostamide F2α negatively regulates adipogenesis.

Silvestri C, Martella A, Poloso NJ, Piscitelli F, Capasso R, Izzo A, Woodward DF, Di Marzo V.

J Biol Chem. 2013 Aug 9;288(32):23307-21. doi: 10.1074/jbc.M113.489906. Epub 2013 Jun 25.

20.

Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis.

Mylona A, Andrieu-Soler C, Thongjuea S, Martella A, Soler E, Jorna R, Hou J, Kockx C, van Ijcken W, Lenhard B, Grosveld F.

Blood. 2013 Apr 11;121(15):2902-13. doi: 10.1182/blood-2012-11-467654. Epub 2013 Feb 6.

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