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Items: 1 to 20 of 21


Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer.

Ngoi NYL, Choong C, Lee J, Bellot G, Wong ALA, Goh BC, Pervaiz S.

Cancers (Basel). 2020 Mar 2;12(3). pii: E574. doi: 10.3390/cancers12030574. Review.



Chong QY, Kok ZH, Bui NL, Xiang X, Li-Ann Wong A, Peng Yong W, Sethi G, Lobie PE, Wang L, Goh BC.

Pharmacol Res. 2020 Feb 14:104686. doi: 10.1016/j.phrs.2020.104686. [Epub ahead of print] Review.


Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential.

Varughese RS, Lam WS, Marican AABH, Viganeshwari SH, Bhave AS, Syn NL, Wang J, Wong AL, Kumar AP, Lobie PE, Lee SC, Sethi G, Goh BC, Wang L.

Cancer. 2019 Jun 1;125(11):1789-1798. doi: 10.1002/cncr.32069. Epub 2019 Apr 1. Review.


Understanding the cancer stem cell phenotype: A step forward in the therapeutic management of cancer.

Wong ALA, Bellot GL, Hirpara JL, Pervaiz S.

Biochem Pharmacol. 2019 Apr;162:79-88. doi: 10.1016/j.bcp.2019.01.020. Epub 2019 Jan 25. Review.


A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs.

Wong AL, Xiang X, Ong PS, Mitchell EQY, Syn N, Wee I, Kumar AP, Yong WP, Sethi G, Goh BC, Ho PC, Wang L.

Pharmaceutics. 2018 Nov 8;10(4). pii: E221. doi: 10.3390/pharmaceutics10040221. Review.


A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study.

Wang L, Phan DK, Syn N, Xiang X, Song H, Thuya WL, Yang S, Wong AL, Kumar AP, Yong WP, Sethi G, Ho PC, Goh BC.

Pharmaceutics. 2018 Aug 8;10(3). pii: E123. doi: 10.3390/pharmaceutics10030123.


Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial.

Syn NL, Wong AL, Lee SC, Teoh HL, Yip JWL, Seet RC, Yeo WT, Kristanto W, Bee PC, Poon LM, Marban P, Wu TS, Winther MD, Brunham LR, Soong R, Tai BC, Goh BC.

BMC Med. 2018 Jul 10;16(1):104. doi: 10.1186/s12916-018-1093-8.


Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models.

Syn NL, Lim PL, Kong LR, Wang L, Wong AL, Lim CM, Loh TKS, Siemeister G, Goh BC, Hsieh WS.

Signal Transduct Target Ther. 2018 Apr 13;3:9. doi: 10.1038/s41392-018-0010-0. eCollection 2018.


Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling.

Wang L, Syn NL, Subhash VV, Any Y, Thuya WL, Cheow ESH, Kong L, Yu F, Peethala PC, Wong AL, Laljibhai HJ, Chinnathambi A, Ong PS, Ho PC, Sethi G, Yong WP, Goh BC.

Cancer Lett. 2018 Mar 28;417:152-160. doi: 10.1016/j.canlet.2017.12.030. Epub 2018 Jan 4.


Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1.

Wang L, Chan CEL, Wong AL, Wong FC, Lim SW, Chinnathambi A, Alharbi SA, Lee LS, Soo R, Yong WP, Lee SC, Ho PC, Sethi G, Goh BC.

Oncotarget. 2017 Jun 20;8(25):41572-41581. doi: 10.18632/oncotarget.15017.


A novel combinatorial strategy using Seliciclib(®) and Belinostat(®) for eradication of non-small cell lung cancer via apoptosis induction and BID activation.

Ong PS, Wang L, Chia DM, Seah JY, Kong LR, Thuya WL, Chinnathambi A, Lau JY, Wong AL, Yong WP, Yang D, Ho PC, Sethi G, Goh BC.

Cancer Lett. 2016 Oct 10;381(1):49-57. doi: 10.1016/j.canlet.2016.07.023. Epub 2016 Jul 25.


Pharmacogenetics-Guided Phase I Study of Capecitabine on an Intermittent Schedule in Patients with Advanced or Metastatic Solid Tumours.

Soo RA, Syn N, Lee SC, Wang L, Lim XY, Loh M, Tan SH, Zee YK, Wong AL, Chuah B, Chan D, Lim SE, Goh BC, Soong R, Yong WP.

Sci Rep. 2016 Jun 14;6:27826. doi: 10.1038/srep27826.


Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development.

Wang L, Phan DD, Zhang J, Ong PS, Thuya WL, Soo R, Wong AL, Yong WP, Lee SC, Ho PC, Sethi G, Goh BC.

Oncotarget. 2016 Jul 12;7(28):44790-44802. doi: 10.18632/oncotarget.8316. Review.


Dose modifications in Asian cancer patients with hepatic dysfunction receiving weekly docetaxel: A prospective pharmacokinetic and safety study.

Syn NL, Wang L, Wong AL, Soe MY, Chuah B, Chan D, Tan SH, Soo RA, Lee SC, Goh BC, Yong WP.

Cancer Sci. 2016 Feb;107(2):173-80. doi: 10.1111/cas.12856. Epub 2016 Feb 8.


Drug sensitivity testing platforms for gastric cancer diagnostics.

Lau V, Wong AL, Ng C, Mok Y, Lakshmanan M, Yan B.

J Clin Pathol. 2016 Feb;69(2):93-6. doi: 10.1136/jclinpath-2015-203426. Epub 2015 Nov 13. Review.


Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.

Wong AL, Lim JS, Sinha A, Gopinathan A, Lim R, Tan CS, Soh T, Venkatesh S, Titin C, Sapari NS, Lee SC, Yong WP, Tan DS, Pang B, Wang TT, Zee YK, Soong R, Trnkova Z, Lathia C, Thiery JP, Wilhelm S, Jeffers M, Goh BC.

J Transl Med. 2015 Feb 12;13:57. doi: 10.1186/s12967-015-0405-4.


Validation of a rapid and sensitive LC-MS/MS method for determination of exemestane and its metabolites, 17β-hydroxyexemestane and 17β-hydroxyexemestane-17-O-β-D-glucuronide: application to human pharmacokinetics study.

Wang LZ, Goh SH, Wong AL, Thuya WL, Lau JY, Wan SC, Lee SC, Ho PC, Goh BC.

PLoS One. 2015 Mar 20;10(3):e0118553. doi: 10.1371/journal.pone.0118553. eCollection 2015.


Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients.

Wang LZ, Ramírez J, Yeo W, Chan MY, Thuya WL, Lau JY, Wan SC, Wong AL, Zee YK, Lim R, Lee SC, Ho PC, Lee HS, Chan A, Ansher S, Ratain MJ, Goh BC.

PLoS One. 2013;8(1):e54522. doi: 10.1371/journal.pone.0054522. Epub 2013 Jan 30. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/df796504-a2ea-4807-a412-85985bb2550b.


Method development and validation for rapid quantification of hydroxychloroquine in human blood using liquid chromatography-tandem mass spectrometry.

Wang LZ, Ong RY, Chin TM, Thuya WL, Wan SC, Wong AL, Chan SY, Ho PC, Goh BC.

J Pharm Biomed Anal. 2012 Mar 5;61:86-92. doi: 10.1016/j.jpba.2011.11.034. Epub 2011 Dec 8.


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