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N Engl J Med. 2019 Jan 3;380(1):11-22. doi: 10.1056/NEJMoa1812792. Epub 2018 Nov 10.

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia.

Collaborators (1974)

Martens FMAC, Schut A, Olshansky B, Chung M, Hallstrom A, Pearce LA, Mehta C, Mukherjee R, Gibson CM, Chakrabarti AK, Gelfand EV, Giugliano RP, Leary MC, Pinto DS, Pride YB, Bhavanthula R, Chester G, Copland C, Diffin K, Erz K, Giaquinto A, Glanton P, Granger A, Iroudayassamy RH, Klevak D, Panchal H, Wang R, Wang SR, Abate G, Berry PJ, Braeckman R, Doogan D, Elson A, HauptmannBaker A, Lamela I, Lubeck C, Manku M, Murphy S, Sanford M, Stirtan W, Soni P, Bastien A, Foster D, Johnson J, Latona L, Palleja S, Sanjuan N, Stager W, Zhang Y, Zhu J, Aertker L, Ankolekar S, Goldberg L, Rajicic N, Shu J, Zou H, Mikhail M, Dawood G, Koshy NM, Mukherjee SK, Abadier R, Lawless AL, McGuinn WP, Weintraub H, Rohr K, Claxton E, Weiss RJ, Klein TD, Nallasivan M, Crowley S, King M, Alfieri AD, Fitz-Patrick D, Loh I, Mayer NJ, Prashad R, Lederman S, Weinstein D, Bays HE, Chu K, Maghsoudi A, Thompson PD, Carstens J, Chang A, Cohen KR, Dean J, Ellison HS, Erickson B, Flores EA, Gottlieb DW, Grena P, Guyton JR, Jones PH, Joseph JM, Lepor NE, Lerman S, Matheney RD, Pacheco TR, Russo MB, Rubino J, Pereira ES, Seals AA, Viera E, Steljes AD, Thompson J, Kapadia S, McIvor M, Salazar JE, Santiago JO, Vicari R, Berk MR, Kaye WA, McKenzie M, Podlecki D, Snyder BD, Nash S, Herrington DM, Johnson W, Lee JR, Blonder R, Patel AM, Castello R, Greco S, Kereiakes DJ, Nadar VK, Nathan M, Potu RP, Sangrigoli R, Smalling R, Davis M, Braastad R, McCriskin J, Bodiwala K, Hargrove JL, Graves MW, Emlein G, Durant RW, Clower JW, Arora R, Singh N, Martin LW, Haught WH, Litt MP, Klein MD, Hoagland P, Goldstein M, Mazzella MS, Dunker DH, Kahn BH, Ince CS Jr, McGrew FA, Lee J, Pan D, Khan SA, Elkayam U, Deeb W, Goldberg AC, Brown CS, Leimbach WN, Backer TS, Sutton DR, Budoff MJ, Gellman J, George AR, Hoffman AS, Kates M, Anand K, Bear R, Cavanaugh BJ, Reyes RG, Sotolongo R, Sabatino K, Gallagher K, Sorial E, Geohas C, Magness KE, Grunstra BP, Martin FA, Knapp WS, Lucas ME, Champlin JJ, Demattia J, Peters PH Jr, Kirstein J, Randall WJ, Staniloae CS, Robinson JG, Adler A, Case C, Kaplan AJ, Lakin GF, Goyle KK, DiGiovanna MJ, Fisher CL, Lillestol M, Robinson M, Perry RG, Levinson LS, Everhart BG, Madder RD, Martin EF, Martin EE, Alam I, Elacion JML, Poonawala R, Desta TT, Robinson JA, Martinez GJ, Reddy JS, Wayne JD, Trenche SM, Kaplan WI, Saavedra RH, DiGregorio MD, Bertolet BD, Fraser NJ, Hart TT, Graf RJ, Jasper DA, Dunn M, Streja DA, Strobl DJ, Jiang N, Kalen V, Mascolo R, Samson MB, Stephens M, Bellard BM, Juarez M, McCarthy PJ, Checton JB, Stillabower M, Goldenberg E, Karim AH, Jaffrani N, Touchon RC, Fruehling ER, Friesen CJ, Chaudhuri P, Morris FH, Broker RE, Patel RJ, Hole S, Miller RP, Miranda FG, Dar S, Gentry SN, Hermany P, Treasure CB, Trevino ME, Acosta R, Japour A, Durr SJ, Wang T, Ganda OP, Krichmar P, Arter JL, Jacoby D, Schwartz MA, Al-Karadsheh A, Gencheff NE, Pasquini JA, Dunbar R, Kohnstamm S, Lozano HF, Welty FK, Pitts TL, Zehnder B, El Hafi S, King MA, Ghitis A, Bahu MM, Jahromi HR, Caputo RP, Busch RS, Shapiro MD, Zavaro S, Daudjee M, Jacobs S, Shah VB, Rubalcava F, Alhaddad MT, Lui H, Rajan RT, Saba FE, Gunapooti MPN, Kayembe TB, Jennings T, Strzinek RA, Shanik MH, Singh PK, Kennedy AC, Rubenstein H, Manshadi R, Broeders MAW, Henrikus D, Kuijper AFM, Al-Windy N, Magro M, Hamraoui K, Aksoy I, Vermeiren GLJ, Roeters van Lennep HWO, Hoedemaker G, Remmen JJ, Bogaard K, van der Heijden D, Knufman NMJ, Frederiks J, Louwerenburg JW, van Rossum P, Milhous J, van der Meer P, van der Weerdt A, Breedveld R, Keijzers M, Hermans W, van de Wal R, Zwart PAG, van der Linden MMJM, Zwiers G, Boswijk DJ, Tans JG, van Eck J, Hessen MV, Hamer BJB, Zoet-Nugteren S, Theunissen L, van Beek EA, Nijmeijer R, Nierop PR, Linssen G, Swart HP, Lenderink T, Bartels GL, den Hartog F, Berg van den BJ, van Kempen W, Kentgens S, Rojas Lingan GM, Peeters MM, Keterberg H, Nierman M, den Hollander AK, Hoogendijk J, Voors-Pette C, Kose V, Viergever P, Yena L, Syvolap V, Kopytsya MP, Barna O, Panina SS, Lutai MI, Shershnyova OV, Luzkiv I, Bula LS, Zotov S, Vyjhovaniuk I, Lysunets O, Koshlia VI, Sydor N, Vayda MF, Ushakov O, Rishko M, Shcherbak VP, Svyshchenko Y, Tseluyko V, Yagensky A, Zolotaikina VI, Godlevska O, Ivanova L, Koval O, Mitchenko OI, Kardash GY, Rudyk YS, Stanislavchuk M, Volkov VI, Karlinskaya OG, Tykhonova SA, Vatutin N, Smirnova G, Kovalenko VM, Lizogub V, Sebov D, Dyadyk O, Andrievskaya S, Krasko MP, Parkhomenko AN, Horbach L, Kupnovytska IG, Pertseva T, Karpenko O, Reshotko D, Zhurba SV, Rudenko L, Zharinova VY, Shatylo VB, Karpenko YI, Orynchak MA, Kameneva TR, Zherlitsina E, Alpenidze DN, Arutyunov GP, Baranova E, Bart B, Belenkiy DI, Boldueva SA, Demchenko EA, Eltishcheva VV, Gofman AM, Goloshchekin BM, Gordeev IG, Gratsianskiy N, Kamalov G, Khasanov NR, Kholina IM, Kobalava ZD, Kobeleva EV, Konradi AO, Kostenko VA, Kuimov AD, Ermakova PY, Malyutina SK, Panov AV, Polezhaeva NV, Reshetko O, Shilkina NP, Shustov SB, Smolyarchuk EA, Stryuk RI, Solovieva EY, Susekov AV, Vezikova N, Ivanova SN, Petrov AA, Konstantinov VO, Agafina AS, Gurevich V, Zrazhevskiy KN, Supryadkina TV, Perepech NB, Arkhipovskiy VL, Butko DY, Zobenko IA, Orlikova OV, Mordovin V, Barbarash OL, Lebedeva A, Nosov V, Averkov OV, Pavlikova EP, Karpov YB, Giorgadze ML, Khrustalev OA, Arkhipov M, Raskina TA, Shilko JV, Samoilova Y, Kosmacheva ED, Nedogoda SV, Coetzee K, Burgess LJ, Theron FCR, Ebrahim IO, Haasbroek GA, Pretorius M, Trokis JS, Urbach DV, Abelson MJ, Horak AR, Badat AE, Makotoko EM, Du Toit Theron H, Ramlachan P, Corbett CH, Mitha IH, Nortje HFM, Jansen van Rensburg DJ, Sebastian PJ, Bester FCJ, van Zyl LJ, Rayner BL, Błach E, Dąbrowska M, Kania G, Kelm-Warchol AE, Kinasz LP, Korecki J, Kruk M, Laskowska-Derlaga E, Madej A, Saminski K, Wasilewska K, Szymkowiak K, Wojciechowska M, Piorowska N, Dyczek A, Abhaichand RK, Byrapaneni RB, Hattur B, Rao MB, Ghaisas N, Kadam SS, Gupta JB, Jayadev SM, Kothiwale VA, Mathur A, Bhaskar V, Aluri RK, Ponangi UP, Sarna MK, Sathe S, Sharma MK, Sawhney JPS, Keshavamurthy CB, Srinivas A, Thacker HP, Sharda A, Joseph J, Dwivedi S, Mohan V, Premchand RK, Bedard J, Bergeron J, Collette R, Crowley D, Dumas R, Henein S, Moran G, O'Mahony WF, O'Mahony M, Chan S, Sherman MH, Wong GC, Carlson BD, Gupta MK, Borts D, Peterson SR, Chilvers M, Kelly AJ, Gregoire JC, Kouz S, Cabau JR, Andor M, Cinteza M, Ciudin R, Cojan RI, Darabont RO, Dumitrascu DL, Fierbinteanu-Braticievici C, Fruntelata AG, Militaru C, Minescu BE, Serban DL, Mitu F, Melicovici DN, Petrascu O, Pirvu OM, Podoleanu C, Pop C, Stanescu-Cioranu RV, Tase A, Voiculet C, Aroney CN, Dart AM, Davis T, Kostner K, O'Neal DN, Purnell PW, Singh BB, Sullivan DR, Thompson P, Watts GF, Blenkhorn AF, Amerena JV, Samie R, Hendriks R, Proietto J, Petrovsky N, Whelan A, Colquhoun D, Scott RS, Young SC, Pegg T, Wilson SJS, Hamer AW, Luke RA, Hart HH, Devlin GP, Wilkins GT, Ternouth IF, Nandra S, Loeprich BS, McGrath N, Tie SL, Ladner J, Kakish L, Kakish A, Little AL, Gerber J, Hinchion NJ, Guarino J, Raychok D, Budzinski S, Kelley-Garvin K, Beckord A, Schlinder J, Schwartzbard A, Cobos S, Freeman D, Abisalih D, McCann D, Guy K, Chase J, Samuelson S, Cassidy M, Tardif M, Smith J, Sprout B, Riedeman N, Goza J, Johnson L, Kraske C, Hastings S, Dutka C, Smith S, McCabe T, Maloney K, Alfieri P, Hosemane V, Syravanh C, Pau C, Limcoiloc A, Carreira T, Kurosawa TS, Krumian R, Preston K, Nashed A, Schneidman-Fernandez D, Patterson J, Tsakonas J, Esaki J, Sprafka L, Patel P, Mitchell B, Ross EM, Miller D, Prashad A, Feyler KM, Juarbe N, Herrera S, Keiran SM, Whitehead B, Asher W, Hobbs C, Elie A, Brooks J, Zaleski AL, Foxen B, Lapke B, Wright P, Pavol B, Carangi G, Turner M, Sanders KW, Delamar RS, Wilson VL, Harvel SM, Cartledge AM, Bailey KR, Mahon K, Schuchard T, Humbert J, Hanson MC, Cecil MP, Abraham JS, Benedict L, Slayton C, Burnett CS, Ono-Lim RW, Budzinski S, Khan SA, Goss S, Techmanski T, Valliani F, Joseph R, Flores E, Contreras L, Aguillon A, Silvia CA, Martin M, Kerut EK, Levenson LW, Glade LB, Cospolich BJ, Stein MW, LaGuardia SP, Sonza TL, Fife TM, Forschler M, Watts J, Fritsch J, Futchko E, Utech S, Baker SB, Roura MF, Segel SA, Magee JS, Jackson C, Goldfaden RF, Quas L, Ortiz EC, Simpson M, Foster R, Brian C, Trimm J, Bailey M, Snoddy B, Reeder V, Wilkinson R, Settle H, Massey C, Maiola A, Hall M, Hall S, Hall W, Xenakis M, Barrett J, Campanile G, Anthou D, Neill SF, Karas S, Polanco E, Schechtman N, Tischner G, Warren K, St Cyr C, Kuczinski M, Alexander L, Ibarra M, Horowitz BS, Steinsapir J, Mangual-Coughlin J, Mooney B, Vasquez P, Rodkey K, Biberstein A, Ignacio C, Robinson I, Hibberd M, Hoffman LB, Murak DJ, Varavenkataraman R, Ohlson Elliott TM, Cunningham LA, Palmerton HL, Poole S, Moore J, Wallace H, Chandler T, Riley R, Dawood F, Azeem A, Cammarata M, Owen A, Aggarwal S, Qureshi W, Almahmoud M, Oseni A, Leigh A, Barnes E, Pflum A, Aladin A, Blinson K, Wayne V, Doomy L, Wall M, Bitterman V, Young C, Grice R, Poliakova L, Davalos J, Rosenbaum D, Boulware M, Mazzola H, Strader JR, Linsky R, Schwartz D, Graf E, Gneiting A, Palmblad M, Donlin A, Ensminger E, Garcia H, Robinson D, Tran C, Jacqmein J, Bartilucci D, Koren M, Maluchnik B, Parks M, Miller J, DeFosse C, Knouse AB Jr, Delancey A, Chin S, Stephens T, Sohal M, Ingram J, Kumar S, Foley H, Smith N, McKinney V, Schwarz L, Moore J, Anderson HV, Sdringola-Maranga S, Denktas A, Turrentine E, Patterson R, Marshall J, Tolar T, Patrick D, Schwartzkopf P, Fletcher AM, Harris FR, Clements S, Brown T, Smith W, Baehl SJ, Fluty R, VanHamersveld D, Breen D, Bender N, Stafford B, Washington T, Pike MN, Stich MA, Jawad E, Nadeem A, Nyland J, Hamer R, Calhoun K, Mall C, Cadogan S, Raynes K, Katz R, Marshall L, Abbas R, Dinerman JL, Hartley JT III, Lamb B, Eskridge L, Raymond D, Clemmer K, Fine DM, Beardsley P, Werner J, Mahan B, VanTol C, Herman R, Raiser-Vignola C, McShan F, Neill SA, Blick DR, Liston MJ, Nelson DK, Dorrell SK, Wyman P, Quraishi A, Ferro F, Morris F, Coombs VJ, Mains AM, Campbell AA, Phelps J, Geary CA, Sheridan EG, Downing JM, Swatkowski A, Redden T, Dragutsky B, Thomas S, Mitchell C, Barker D, Turcotte E, Segerson D, Guy J, De La Mora K, Hong J, Do D, Norris R, Khan F, Montero H, Kelly-White S, Cleland A, Alcalde-Crawford R, Morgan M, Sarabu B, Minor M, Kamat S, Estes SM, Harless N, Disney A, Pagano JL, Alford CM, Bedwell NW, Hardy WD, DeAndrade K, Elmore JG, Auerbach EG, Haney AW, Brooks MH, Torres J, Roper L, Backer T, Backer K, Evans JG, Silva RA, Dajani LH, Yousif V, Ross T, Roy SK, Oudiz R, Hamal S, Flores F, Leahy A, Ayer D, George S, Stewart CC, Orellana E, Boccalandro C, Rangel M, Hennings S, Vanselow C, Victor T, Birdwell D, Haas P, Sandoval A, Ciavarella G, Saglam C, Bird A, Beck K, Poliquin B, Dominguez D, Tenorio B, Perkins H, San Roman E, Bransford P, Lowrance C, Broussard M, Ellis M, Skiles B, Hamilton J, Hall K, Olvera D, Hartwell JA, Sorial N, Rickman M, Berman K, Mehta N, Laborin A, Rothenberger R, Beauvilliers S, Morrell K, Schachter MP, Perkins CL, Gordon EA, Lauer J, Bichsel K, Oliver K, Mellor LJ, Demattia C, Schomburg J, Moreno Y, Mansur-Garza E, Rippstein L, Chacon L, Pena A, King M, Richardson S, Jessop A, Tucker N, Royer W, Templeton G, Moell A, Weller C, Botts MJ, Hollon G, Homberg-Pinassi E, Forest P, Bin Abhulhak A, Chun-Furlong D, Harrington D, Harlynn E, Schmitt M, Shelsky C, Feldick P, Cherrico M, Jagle C, Warnecke N, Myer D, Ruder DJ, Underwood A, Rauba A, Carr G, Oberhaus B, Vanderfeltz J, Stucky-Heil MJ, Gibson DR, Fuentes V, Talbot KL, Simon WC, Grimes KJ, Wheeler CR, Shultz C, Metcalf RA, Hill JL, Oliver MR, Ahmad B, Azeem F, Rahim A, Freeman GH, Bloch D, Freeman H, Brown J, Rosbach S, Melander P, Taralson N, Liu A, Harms K, Michale M, Lopez J, Revoredo M, Edevane S, Shawley S, Jackson TL, Oliver MJ, DeSalle D, Matlock PJ, Beraun IM, Hendrix H, Bromley G, Niemerski A, Teran G, Guerrero S, Marvi M, Palanpurwala Z, Torres A, Gloyd P, Conger M, Laurent A, Nayor O, Villanueva CS, Khambati M, Mumford TJ, Castillo MJ, Desta T, Robinson J, Woods S, Bahri AH, Herrera N, Casaclang C, Unger JR, Martinez G, Moon MK, Mohaupt SM, Sandoval L, Valenzuela L, Ramirez V, Mata N, Avila V, Patino M, Montano-Pereira C, Barnett O, Webster WM, Christensen LM, Bofman L, Livingston M, Adams S, Hobbs J, Koskela L, Katz M, Mujica-Trenche S, Cala F, Rana NT, Scarlett J, Anaya MC, Jones MR, Hollis KD, Roth D, Eads K, Watts T, Perkins J, Arnold A, Ginsberg DC, Quinn D, Cureton N, Fittingoff DB, Iqbal MI, White SR, Sisneros E, Ducca M, Streja D, Campos D, Boak JL, Amir F, Anderson F, Kmetzo JJ, Bongarzone MO, Scott D, De Leon MG, Buda C, Graettinger W, Alex M, Hess E, Govoni J, Bartel M, Monchamp TL, Roach JS, Gibson S, Allfrey AM, Timpy K, Bott K, Soucy KA, Willis J, Valerio CA, Chunduri A, Coker R, Vidrine N, Thompson EA, Studeny MA, Marcum MK, Monway TS, Kosmicki DL, Kelley MJ, Godfrey CM, Krenk SL, Holcomb RR, Baehr DK, Trauernicht MK, Lowry DR, Herts BB, Phelps JE, Downing JM, Dignon CG, Cockrill ES, Chapla PG, Fera D, Chang M, Fredette P, Ashby T, Bergin R, Stearns ZA, Ware DB, Boudreaux RM, Rodriguez J, McKenzie R, Huber A, Sommers R, Rowe H, McLallen S, Haynes M, Adamson A, Henderson J, McClure L, Harris BA, Ference L, Meissner-Dengler S, Treasure L, Nicely D, Light TL, Osborn TA, Mai KJ, Vivas P, Rios J, Rodriguez D, DeRaad R, Walder J, Bailon O, Hockett D, Anderson D, McIntosh K, Odegard A, Shepherd A, Seifert M, Kelley L, Shetty R, Castine M, Brill D, Fisher G, Richmond N, Gray K, Miller P, Coneys C, Chanza Y, Sumoza M, Caudill VM, Harris KD, Manion CA, Lineberger-Moore MJ, Wolfe JJ, Rosen BJ, DiVito P, Moffat JL, Michaelis C, Koshy P, Perea D, Al Yacoub G, Sadeghi S, LeGalley TD, Evonich RF, Jean WJ, Friesen GM, Pap JM, Pesola DA, Cowan MD, Dosh KM, Larson D, Price AM, Nease JA, Anderson JE, Piggott LA, Iwaoka R, Sharkey K, McMillan E, Lowder L, Morgan L, Davis K, Caldwell T, Breglio E, Summers J, Poulimas R, Zahid M, Syed H, Escobar M, Levy J, Warsi R, Ma C, Cen P, Cawthon KA, Barnes DB, Allen DG, Warrington ML, Stastny CR, Michaels RJ, Saleh M, Sorin J, Rathod S, Juett U, Spencer S, Keval A, McBride J, Young S, Baxter C, Rasmussen C, Coxe SL, Campos L, Tavackoli S, Beckham D, Sanchez D, Basrai K, Helms D, Clinton E, Smith K, Cusnir H, Clark MK, Cherukuri MV, Scarfaru A, Nash SD, Grimm LC, Grace A, McElheran K, Subasic D, Buhay Z, Litvinoff J, Shah D, Cervantes S, Usher F, Yasser F, Trusevich T, Garcia RL, Wyatt J, Bose R, Miska H, Spivey T, Wren AB, Vance KE, Holman LL, Gibbons P, Eby E, Shepard S, Charoenthongtrakul S, Snodgrass B, Nazem M, Keteenburg S, Murthy P, Prater F, Rumfelt A, Eizensmits C, Iannuzzi L, Patel PR, Bergamino C, McFeaters E, Rizk B, Pflaum E, Kalish D, Ambatali R, Ameli M, Sanguinetti D, Vaidya R, Bos RJ, Wils A, Jacobs T, Badings EA, Ebels-Tuinbeek LA, Scholten ML, Bayraktar-Verver E, Zweers D, Schiks M, Kalkman C, Tiemes T, Mulderij J, Hermans W, Dabrowska K, Wijnakker W, Vd Loo R, DeGraauw J, Reijnierse G, van der Zeijst M, Scholten M, Hofmeijer HR, van Dijk-van der Zanden A, van Belle DJ, Van Es J, Van Buchem G, Zijda W, Verheij H, Oldenhof-Janssen L, Bader M, Löwik M, Stuij S, Vantrimpont P, van Aken K, Hamilton K, Blömer H, van Laerhoven G, Tukkie R, Janssen M, Verdel G, Küpper JF, van Vlies B, Kalkman C, Vooges J, Vermaas M, de Graauw J, Van de Loo R, Langenberg R, Haenen N, Smeets F, Scheepmaker A, Grosfeld M, Van Lieshout I, van den Berg M, Wittekoek M, Mol P, Stapel A, Sierevogel M, vd Ven N, Berkelmans A, Viergever E, Kramer H, Engelen W, Houwelingen KV, Wildbergh TX, Mosterd A, Hobé-Rap, Corietvan Doorn M, Bunschoten P, Freericks M, Emans M, Den Boer-Penning P, Verlek E, Freericks C, de Nooijer C, Welten C, Groenenberg I, van der Horst C, Vonk E, Tjeerdsma G, Jochemsen GM, van Daalen C, Danse IY, Kuipers L, Pieterse A, Oomen A, de Waard D, Flu WJ, Kromhout Z, Van der Bij P, Feld R, Hessels-Linnemeijer B, Lardinois R, Posma JL, Aukema-Wouda ZR, Hendriks-van Woerden M, van Wijk D, Beelen DP, Hendriks IH, Jonker JJ, Schipperen S, Köse V, Rojas G, Goedhart L, van Meurs H, Rijssemus J, Swinkels-Diepenmaat L, de Louw-Jansen M, Bierens-Peters D, van Kempen WW, Wittekoek ME, Agous I, Schenk G, Wittekoek J, Cox K, Julia DF, Jonker JJC, Janssen R, Nierman M, Katerberg H, van der Haar I, van Mesdag T, Alvarez Costa LM, Schensema M, Zweekhorst S, Julia DF, Hanewinckel L, Olsthoorn J, Berends JC, van der Spek AC, van der Berg R, Timmermann RJ, Boerema I, Mudruk I, Khrystoforova A, Kyselov S, Hilova YV, Logoida P, Sanina NA, Golikova IP, Nemchyna OO, Isaichikov II, Potapova OB, Gura IV, Berestetska L, Kulianda OO, Tantsura O, Kulbachuk OS, Petsentiy V, Biskub I, Handych T, Lagkuti O, Gagarina A, Chendey T, Bilonko OF, Matova O, Bezrodna L, Yarynkina O, Ovdiienko T, Randchenko V, Mospan M, Butko O, Romanenko O, Pavelko M, Sichkaruk I, Lazareva SO, Kudryk OA, Koltsun IM, Magdalits T, Zadorozhniy S, Kompaniiets K, Ivanov A, Romanenko S, Kaplan P, Romanov VY, Mykytyuk OP, Zaitseva NS, Pyvovar SN, Burdeuna L, Serdobinska E, Shevchenko TI, Ivanytskyi II, Khyzhnyak OV, Kalinkina N, Keting O, Sklyanna O, Kashanska O, Shevelok A, Khristichenko M, Titov IY, Oleksander DO, Polenova NS, Altunina N, Kororaieva V, Zborovskiy S, Kholopov L, Suliman I, Lukashenko L, Shvaykin S, Glavatskiy OM, Sychov RO, Kulynych RL, Skarzhevskyi OA, Dovgan NV, Horbach M, Cherkasova O, Tyshchenko I, Todoriuk L, Kizim S, Brodi N, Ivanko O, Garbarchuk O, Alieksieieva L, Shandra TL, Beregova O, Bodretska LA, Naskalova SS, Antoniuk-Shcheglova IA, Bondarenko OV, Andreeva NG, Vakalyuk II, Chovganyuk OS, Artemenko NR, Maltsev KA, Kalishevich N, Kondratyeva NG, Nikitina SA, Martjanova MV, Sokolova AV, Dragunov DO, Kolesnik O, Larina V, Tsygankova OV, Ivanova M, Karpov IA, Aronova EM, Vedernikova ES, Lubinskaya EI, Burak TY, Skichko SI, Rasulev F, Soldatova EB, Fenin AL, Laptev II, Luchinkina EE, Akatov A, Polenova NV, Slavina NN, Korovnika IN, Prochorova MY, Shakirova R, Andreicheva EN, Krasnova OA, Lobzhanidze TV, Dmitrova TB, Stakhiv VV, Pechatnikova MI, Panova AV, Tipikina MY, Rotar OP, Bokovin NA, Karabalieva SK, Tumarov FY, Vasileva EV, Lozhkina NG, Filippova EV, Sharkaeva AI, Filippova EV, Tolkacheva NY, Domracheva EN, Ryabikov AN, Abesadze IT, Alugishvili MZ, Nikolaeva EP, Smirnova NV, Rodionova VI, Dolovstaya PV, Yunonin IE, Kadin SV, Sveklina TS, Bushmanova AV, Barkova EL, Gomova IS, Brytkova YV, Ivanova TB, Zubareva MY, Skopets I, Galashevskaya LA, Butinskaya ED, Gusarova OG, Kalishevich NB, Pavlova YR, Serebrenitskaya MP, Grygorieva VF, Kuchaeva GR, Vasileva IA, Ospanova GI, Vahrusheva YV, Semenova IA, Mikhailova IEE, Kvasova OO, Shurygina VD, Rivin AE, Savelyev AO, Savelyev AA, Milyaeva OO, Lapshina NN, Lantsova NA, Alexandrov PV, Orlikov EA, Falkovskaya A, Ripp T, Triss S, Pekarskiy S, Ekaterina S, Zhuravleva EN, Perova O, Kovaleva G, Koroleva L, Mishchenko L, Garshin BP, Kutuzova SA, Provotorova LI, Zadvorny IP, Okhapkina OV, Khrustalev AO, Suvorova T, Shaf ES, Vershinina VA, Kozulin AA, Oleynik OA, Martynova IY, Kizhvatova NV, Salasyuk AS, Tsoma VV, Ledyaeva AA, Chumachek EV, Blignaut SC, Alexander TY, Du Plessis C, Govender T, Du Toit SM, Motala L, Gassiep A, Naude C, Terblanche M, Snoer M, Pillay B, Basson V, Theron ME, Fouche B, Coetzee ME, Odendall P, Van Wijk FH, Conradie AM, Van der Westhuizen T, Tredoux C, Mookdam MS, Van der Merwe AJ, Snyman K, Smal G, De Jager Y, Mabin TA, King A, Henley LL, Zwane BM, Robinson J, Karsten M, Page AM, Nsabiyumva V, Krahenbuhl C, Patel JD, Motala YE, Dawood A, Koza NB, Peters LMS, Ramlachan S, Bodenstein WJ, Roux P, Fouche L, Boshoff CM, Mitha HM, Khan F, Cyster HP, Cyster H, Wessels EC, Jacobs FJ, Sebastian MA, Sebastian DA, Mahomed N, Immink IP, Cotzee C, Cronje T, Roscher M, Le Roux M, Trinder YA, Wnętrzak-Michalska R, Piszczek M, Piela A, Czernecka E, Knychas D, Walczak A, Gładysz I, Filas K, Kiluk E, Świgło K, Jędrzejczyk I, Łuczyńska K, Tymendorf K, Piesiewicz W, Kinasz WL, Samborski S, Bartuś I, Korecka GL, Gulaj E, Sopa J, Derlaga B, Baisiak M, Kowalisko A, Stainszewska-Marasazlek E, Szafran B, Swiatkiewicz M, Racewicz A, Grycel S, Supronik J, Walendziuk S, Tarantowicz M, Stasiak A, Sidorowicz-Białynicka A, Dwojak M, Jaźwińska-Tarnawska E, Kupczyk K, Martowska K, Kulon K, Gajda K, Wilson B, Velusamy K, Sadhiq SS, Siddeshi B, Bhanukumar M, Srivatsav A, Ramesh M, Chalasani SH, Johnson M, Gopu P, George J, Reddy S, Thara Eleena ST, Kodem DR, Nakkella HN, Mandula PK, Vuriya AK, Rajana S, Kale A, Rajeev T, Jain R, Jain V, Adhyapak SM, Sheeba L, Uma CR, Ramya R, Kulkarni AV, Ganachari MS, Sambrekar R, Bilal M, Chakravarthy NK, Badhavath R, Kumar S, Simhadri M, Salamuddin F, Prasad V, Dwivedi V, Sarna S, Arora T, Chawla D, Sathe A, Gayatree C, Nanda A, Avtar R, Sharma J, Vaibhavi PS, Sasirekha D, Kobbajji D, Ningappa R, Shree S, Chandrashekar K, Nandini MR, Sowjanya S, Devika IG, Yashaswini N, Sonika G, Rathna L, Priyanka R, Shrimanker RJ, Reddy LV, Sumathi K, Devi B, Naik BN, Manjunath R, Ashok R, Kunjumon TV, Thomas J, Samdhani S, Selvam K, Subramani P, Parthasarathy N, Bohra NK, Gatla AK, Horbatuk C, Sills J, Davey EB, Paramonczyk L, Racanelli O, Strybosch S, Belanger A, Palardy J, Schiffrin A, Gauthier S, Kalyniuk N, Whatley SD, Lappala H, Patel G, Reeve M, Moran C, Everitt J, Ferrari T, Bouffard C, Frohlich J, Francis G, Mancini J, Bondy G, DeAngelis D, Fulton P, Blank DW, Lombardo A, Roy M, Chow J, Fox H, Grootendorst WJ, Hutchinson A, Chan SM, Fitzgerald C, Wilkins L, Raymond RL, Reyes A, André LM, Fortin D, Ouimet H, Tôn-Nu TT, Dussureault M, Blain MH, Roy M, Kopajko N, Fleury C, Maheux K, Ciobotaru GV, Constantinescu MC, Gherghinescu CL, Avram AM, Manitiu I, Sinpetrean A, Pop L, Lupu D, Usvat R, Petrisor A, Dumitru N, Moruju C, Gheorghita A, Mitu MV, Macarie C, Pop AM, Diaconu MC, Grancea I, Cosma M, Crisan M, Herron E, Nestel P, Kay SB, Carter KS, Badshah I, Makepeace A, Drinkwater J, England M, Rafei A, Patterson K, Jenkins A, McAuley S, Kent SM, Vibert JE, Perrett L, David T, Kaye SL, O'Connor M, Perera NJ, Lai NT, Kearins KA, Dicamillo C, Anderson H, Ferguson L, Radtke SD, Thamarappillil CT, Boys JM, Long AK, Shanahan T, Nyguyen M, Forrest N, Tulloch G, Greenwell D, Price SL, Tint AN, Sumithran PK, Debreceni TL, Walker L, Caruana M, Edwards K, Stathopoulos M, Haywood C, Sajkov D, Pringle S, Tabner A, Bartolay K, Abeyratne C, Bragg K, Mulhern P, Purnell P, Williams L, Hamlyn J, Connelly A, Hoffman J, Bailey S, Kerr J, Morrison Z, Maeder S, McEwan R, Kunasekera P, McGregor P, Young J, Berry S, Cutfield R, Choe M, McNamara C, Shergill NK, Crone P, Williams MG, Dyson K, Schmid DH, Doak AC, Spooner M, Edwards C, Turner A, McAnnalley GM, Fisher RA, Hamilton FB, Friedlander DH, Kirk MR, Scales JE, McLelland MA, Dalman NA, Vickers CE, Jackson C, Coleman W, Garden PI, Arnold WF.

Abstract

BACKGROUND:

Patients with elevated triglyceride levels are at increased risk for ischemic events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride levels, but data are needed to determine its effects on ischemic events.

METHODS:

We performed a multicenter, randomized, double-blind, placebo-controlled trial involving patients with established cardiovascular disease or with diabetes and other risk factors, who had been receiving statin therapy and who had a fasting triglyceride level of 135 to 499 mg per deciliter (1.52 to 5.63 mmol per liter) and a low-density lipoprotein cholesterol level of 41 to 100 mg per deciliter (1.06 to 2.59 mmol per liter). The patients were randomly assigned to receive 2 g of icosapent ethyl twice daily (total daily dose, 4 g) or placebo. The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or unstable angina. The key secondary end point was a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke.

RESULTS:

A total of 8179 patients were enrolled (70.7% for secondary prevention of cardiovascular events) and were followed for a median of 4.9 years. A primary end-point event occurred in 17.2% of the patients in the icosapent ethyl group, as compared with 22.0% of the patients in the placebo group (hazard ratio, 0.75; 95% confidence interval [CI], 0.68 to 0.83; P<0.001); the corresponding rates of the key secondary end point were 11.2% and 14.8% (hazard ratio, 0.74; 95% CI, 0.65 to 0.83; P<0.001). The rates of additional ischemic end points, as assessed according to a prespecified hierarchical schema, were significantly lower in the icosapent ethyl group than in the placebo group, including the rate of cardiovascular death (4.3% vs. 5.2%; hazard ratio, 0.80; 95% CI, 0.66 to 0.98; P=0.03). A larger percentage of patients in the icosapent ethyl group than in the placebo group were hospitalized for atrial fibrillation or flutter (3.1% vs. 2.1%, P=0.004). Serious bleeding events occurred in 2.7% of the patients in the icosapent ethyl group and in 2.1% in the placebo group (P=0.06).

CONCLUSIONS:

Among patients with elevated triglyceride levels despite the use of statins, the risk of ischemic events, including cardiovascular death, was significantly lower among those who received 2 g of icosapent ethyl twice daily than among those who received placebo. (Funded by Amarin Pharma; REDUCE-IT ClinicalTrials.gov number, NCT01492361 .).

PMID:
30415628
DOI:
10.1056/NEJMoa1812792
[Indexed for MEDLINE]

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