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Items: 1 to 20 of 95

1.

Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.

Salgado-Polo F, van Veen M, van den Broek B, Jalink K, Leyton-Puig D, Perrakis A, Moolenaar WH, Matas-Rico E.

J Cell Sci. 2020 Feb 10;133(3). pii: jcs235044. doi: 10.1242/jcs.235044.

2.

The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions.

Salgado-Polo F, Perrakis A.

Cancers (Basel). 2019 Oct 16;11(10). pii: E1577. doi: 10.3390/cancers11101577. Review.

3.

The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity.

Adamopoulos A, Heidebrecht T, Roosendaal J, Touw WG, Phan IQ, Beijnen J, Perrakis A.

J Biol Chem. 2019 Aug 23;294(34):12815-12825. doi: 10.1074/jbc.RA119.007393. Epub 2019 Jul 10.

PMID:
31292194
4.

Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.

Adamopoulos A, Landskron L, Heidebrecht T, Tsakou F, Bleijerveld OB, Altelaar M, Nieuwenhuis J, Celie PHN, Brummelkamp TR, Perrakis A.

Nat Struct Mol Biol. 2019 Jul;26(7):567-570. doi: 10.1038/s41594-019-0254-6. Epub 2019 Jul 1.

PMID:
31270470
5.

Building and rebuilding N-glycans in protein structure models.

van Beusekom B, Wezel N, Hekkelman ML, Perrakis A, Emsley P, Joosten RP.

Acta Crystallogr D Struct Biol. 2019 Apr 1;75(Pt 4):416-425. doi: 10.1107/S2059798319003875. Epub 2019 Apr 4.

6.

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing.

Pachis ST, Hiruma Y, Tromer EC, Perrakis A, Kops GJPL.

Cell Rep. 2019 Feb 19;26(8):2101-2112.e6. doi: 10.1016/j.celrep.2019.01.017.

7.

Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1.

Hayashi A, Giakoumakis NN, Heidebrecht T, Ishii T, Panagopoulos A, Caillat C, Takahara M, Hibbert RG, Suenaga N, Stadnik-Spiewak M, Takahashi T, Shiomi Y, Taraviras S, von Castelmur E, Lygerou Z, Perrakis A, Nishitani H.

Life Sci Alliance. 2018 Dec 31;1(6):e201800238. doi: 10.26508/lsa.201800238. eCollection 2018 Dec.

8.

A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop.

Roorda JC, Joosten RP, Perrakis A, Hiruma Y.

Proteins. 2019 Apr;87(4):348-352. doi: 10.1002/prot.25651. Epub 2019 Jan 8.

9.

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1.

van Beusekom B, Heidebrecht T, Adamopoulos A, Fish A, Pardon E, Steyaert J, Joosten RP, Perrakis A.

Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):690-695. doi: 10.1107/S2053230X18010282. Epub 2018 Oct 16.

PMID:
30387773
10.

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation.

Argenzio E, Klarenbeek J, Kedziora KM, Nahidiazar L, Isogai T, Perrakis A, Jalink K, Moolenaar WH, Innocenti M.

J Biol Chem. 2018 Dec 14;293(50):19161-19176. doi: 10.1074/jbc.RA118.002779. Epub 2018 Oct 31.

11.

Homology-based loop modeling yields more complete crystallographic protein structures.

van Beusekom B, Joosten K, Hekkelman ML, Joosten RP, Perrakis A.

IUCrJ. 2018 Aug 8;5(Pt 5):585-594. doi: 10.1107/S2052252518010552. eCollection 2018 Sep 1.

12.

Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.

Salgado-Polo F, Fish A, Matsoukas MT, Heidebrecht T, Keune WJ, Perrakis A.

J Biol Chem. 2018 Sep 14;293(37):14312-14327. doi: 10.1074/jbc.RA118.004450. Epub 2018 Jul 19.

13.

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ.

Nat Cell Biol. 2018 Jul;20(7):800-810. doi: 10.1038/s41556-018-0130-3. Epub 2018 Jun 18.

14.

iNEXT: a European facility network to stimulate translational structural biology.

iNEXT Consortium.

FEBS Lett. 2018 Jun;592(12):1909-1917. doi: 10.1002/1873-3468.13062. Epub 2018 May 15. No abstract available.

15.

Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish.

van Veen M, Mans LA, Matas-Rico E, van Pelt J, Perrakis A, Moolenaar WH, Haramis AG.

Int J Biochem Cell Biol. 2018 Jan;94:71-78. doi: 10.1016/j.biocel.2017.11.015. Epub 2017 Dec 22.

16.

Homology-based hydrogen bond information improves crystallographic structures in the PDB.

van Beusekom B, Touw WG, Tatineni M, Somani S, Rajagopal G, Luo J, Gilliland GL, Perrakis A, Joosten RP.

Protein Sci. 2018 Mar;27(3):798-808. doi: 10.1002/pro.3353. Epub 2017 Dec 8.

17.

Vasohibins encode tubulin detyrosinating activity.

Nieuwenhuis J, Adamopoulos A, Bleijerveld OB, Mazouzi A, Stickel E, Celie P, Altelaar M, Knipscheer P, Perrakis A, Blomen VA, Brummelkamp TR.

Science. 2017 Dec 15;358(6369):1453-1456. doi: 10.1126/science.aao5676. Epub 2017 Nov 16.

PMID:
29146869
18.

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells.

van Veen M, Matas-Rico E, van de Wetering K, Leyton-Puig D, Kedziora KM, De Lorenzi V, Stijf-Bultsma Y, van den Broek B, Jalink K, Sidenius N, Perrakis A, Moolenaar WH.

Elife. 2017 Aug 29;6. pii: e23649. doi: 10.7554/eLife.23649.

19.

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

Hiruma Y, Koch A, Hazraty N, Tsakou F, Medema RH, Joosten RP, Perrakis A.

J Biol Chem. 2017 Sep 1;292(35):14496-14504. doi: 10.1074/jbc.M117.783555. Epub 2017 Jul 18.

20.

Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.

Keune WJ, Potjewyd F, Heidebrecht T, Salgado-Polo F, Macdonald SJ, Chelvarajan L, Abdel Latif A, Soman S, Morris AJ, Watson AJ, Jamieson C, Perrakis A.

J Med Chem. 2017 Mar 9;60(5):2006-2017. doi: 10.1021/acs.jmedchem.6b01743. Epub 2017 Feb 16.

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