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Items: 1 to 20 of 23

1.

The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.

Cappoen D, Torfs E, Meiresonne T, Claes P, Semina E, Holvoet F, de Macedo MB, Cools F, Piller T, Matheeussen A, Van Calster K, Caljon G, Delputte P, Maes L, Neyrolles O, De Kimpe N, Mangelinckx S, Cos P.

Eur J Med Chem. 2019 Jul 19;181:111549. doi: 10.1016/j.ejmech.2019.07.052. [Epub ahead of print]

PMID:
31376569
2.

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents.

Sijm M, Siciliano de Araújo J, Llorca AR, Orrling K, Stiny L, Matheeussen A, Maes L, de Esch IJP, Soeiro MNC, Sterk GJ, Leurs R.

ChemMedChem. 2019 Jul 18. doi: 10.1002/cmdc.201900370. [Epub ahead of print]

PMID:
31319019
3.

Synthesis and antimicrobial activities of N6-hydroxyagelasine analogs and revision of the structure of ageloximes.

Paulsen B, Fredriksen KA, Petersen D, Maes L, Matheeussen A, Naemi AO, Scheie AA, Simm R, Ma R, Wan B, Franzblau S, Gundersen LL.

Bioorg Med Chem. 2019 Feb 15;27(4):620-629. doi: 10.1016/j.bmc.2019.01.002. Epub 2019 Jan 4.

PMID:
30638761
4.

In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis.

Okba MM, Sabry OM, Matheeussen A, Abdel-Sattar E.

Future Med Chem. 2018 Dec 4. doi: 10.4155/fmc-2018-0180. [Epub ahead of print]

PMID:
30511591
5.

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.

Blaazer AR, Singh AK, de Heuvel E, Edink E, Orrling KM, Veerman JJN, van den Bergh T, Jansen C, Balasubramaniam E, Mooij WJ, Custers H, Sijm M, Tagoe DNA, Kalejaiye TD, Munday JC, Tenor H, Matheeussen A, Wijtmans M, Siderius M, de Graaf C, Maes L, de Koning HP, Bailey DS, Sterk GJ, de Esch IJP, Brown DG, Leurs R.

J Med Chem. 2018 May 10;61(9):3870-3888. doi: 10.1021/acs.jmedchem.7b01670. Epub 2018 May 1.

6.

Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.

Salado IG, Baán A, Verdeyen T, Matheeussen A, Caljon G, Van der Veken P, Kiekens F, Maes L, Augustyns K.

Eur J Med Chem. 2018 May 10;151:18-26. doi: 10.1016/j.ejmech.2018.03.048. Epub 2018 Mar 23.

PMID:
29604541
7.

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes.

Saad M, Bijttebier S, Matheeussen A, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, Maes L, Cos P, Van Cruchten S.

Data Brief. 2017 Dec 6;16:644-648. doi: 10.1016/j.dib.2017.11.079. eCollection 2018 Feb.

8.

In vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds.

Saad M, Matheeussen A, Bijttebier S, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, Apers S, Maes L, Cos P, Van Cruchten S.

Toxicol In Vitro. 2017 Aug;42:329-336. doi: 10.1016/j.tiv.2017.05.009. Epub 2017 May 12.

PMID:
28506817
9.

In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.

De Vita D, Moraca F, Zamperini C, Pandolfi F, Di Santo R, Matheeussen A, Maes L, Tortorella S, Scipione L.

Eur J Med Chem. 2016 May 4;113:28-33. doi: 10.1016/j.ejmech.2016.02.028. Epub 2016 Feb 15.

PMID:
26922226
10.

Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity.

Mowbray CE, Braillard S, Speed W, Glossop PA, Whitlock GA, Gibson KR, Mills JE, Brown AD, Gardner JM, Cao Y, Hua W, Morgans GL, Feijens PB, Matheeussen A, Maes LJ.

J Med Chem. 2015 Dec 24;58(24):9615-24. doi: 10.1021/acs.jmedchem.5b01456. Epub 2015 Dec 4.

PMID:
26571076
11.

Synthesis and in vitro evaluation of tropane halogenated-derivatives against malaria, sleeping sickness, Chagas disease and leishmaniasis.

Cretton S, Bartholomeusz TA, Mehl F, Allenbach Y, Matheeussen A, Cos P, Maes L, Christen P.

Med Chem. 2014;10(8):753-8.

PMID:
24813684
12.

Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of Hypericum perforatum and their LC-DAD-MS analyses.

Orhan IE, Kartal M, Gülpinar AR, Cos P, Matheeussen A, Maes L, Tasdemir D.

Food Chem. 2013 Jun 1;138(2-3):870-5. doi: 10.1016/j.foodchem.2012.11.053. Epub 2012 Nov 20.

PMID:
23411190
13.

Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra.

Mothana RA, Al-Musayeib NM, Matheeussen A, Cos P, Maes L.

Molecules. 2012 Dec 3;17(12):14349-60. doi: 10.3390/molecules171214349.

14.

Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia.

Al-Musayeib NM, Mothana RA, Al-Massarani S, Matheeussen A, Cos P, Maes L.

Molecules. 2012 Sep 25;17(10):11379-90.

15.

In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region.

Al-Musayeib NM, Mothana RA, Matheeussen A, Cos P, Maes L.

BMC Complement Altern Med. 2012 Apr 20;12:49. doi: 10.1186/1472-6882-12-49.

16.

Integrated dataset of screening hits against multiple neglected disease pathogens.

Nwaka S, Besson D, Ramirez B, Maes L, Matheeussen A, Bickle Q, Mansour NR, Yousif F, Townson S, Gokool S, Cho-Ngwa F, Samje M, Misra-Bhattacharya S, Murthy PK, Fakorede F, Paris JM, Yeates C, Ridley R, Van Voorhis WC, Geary T.

PLoS Negl Trop Dis. 2011 Dec;5(12):e1412. doi: 10.1371/journal.pntd.0001412. Epub 2011 Dec 20.

17.

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr).

Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Gräwert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T.

J Med Chem. 2011 Oct 13;54(19):6796-802. doi: 10.1021/jm200694q. Epub 2011 Sep 13.

PMID:
21866890
18.

Structure elucidation and NMR assignments of two new triterpenoids from the stems of Paragonia pyramidata (Bignoniaceae).

Wang XL, Hay AE, Matheeussen A, Gupta MP, Hostettmann K.

Magn Reson Chem. 2011 Apr;49(4):184-9. doi: 10.1002/mrc.2726. Epub 2011 Mar 9.

PMID:
21391240
19.

Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza-minika A. Chevalier (Ebenaceae).

Tangmouo JG, Ho R, Matheeussen A, Lannang AM, Komguem J, Messi BB, Maes L, Hostettmann K.

Phytother Res. 2010 Nov;24(11):1676-9. doi: 10.1002/ptr.3192.

PMID:
21031627
20.

In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models.

de Wit K, Paulussen C, Matheeussen A, van Rossem K, Cos P, Maes L.

Antimicrob Agents Chemother. 2010 Nov;54(11):4927-9. doi: 10.1128/AAC.00730-10. Epub 2010 Aug 30.

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