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Materials (Basel). 2017 Apr 18;10(4). pii: E425. doi: 10.3390/ma10040425.

The In Vitro Bioactivity, Degradation, and Cytotoxicity of Polymer-Derived Wollastonite-Diopside Glass-Ceramics.

Author information

1
Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas, Federal University of ABC, Santo André 09210-580, Brazil. amanda.juraski@gmail.com.
2
Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas, Federal University of ABC, Santo André 09210-580, Brazil. andreadorion@gmail.com.
3
Dipartimento di Ingegneria Industriale, University of Padova, Padova 35131, Italy. elsisy_chem@yahoo.com.
4
Ceramics Department, National Research Centre, El-Bohous Street, 12622 Cairo, Egypt. elsisy_chem@yahoo.com.
5
Dipartimento di Ingegneria Industriale, University of Padova, Padova 35131, Italy. enrico.bernardo@unipd.it.
6
Departamento de Ciências, State University of Maringá, Maringá 87360-000, Brazil. soares.v.o@gmail.com.
7
Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas, Federal University of ABC, Santo André 09210-580, Brazil. enrico.bernardo@unipd.it.

Abstract

Ca-Mg silicates are receiving a growing interest in the field of bioceramics. In a previous study, wollastonite-diopside (WD) glass-ceramics were successfully prepared by a new processing route, consisting of the heat treatment of a silicone resin embedding reactive oxide particles and a Ca/Mg-rich glass. The in vitro degradation, bioactivity, and cell response of these new WD glass-ceramics, fired at 900-1100 °C for 1 h, as a function of the Ca/Mg-rich glass content, are the aim of this investigation The results showed that WD glass-ceramics from formulations comprising different glass contents (70-100% at 900 °C, 30% at 1100 °C) exhibit the formation of an apatite-like layer on their surface after immersion in SBF for seven days, thus confirming their surface bioactivity. The XRD results showed that these samples crystallized, mainly forming wollastonite (CaSiO₃) and diopside (CaMgSi₂O₆), but combeite (Na₂Ca₂Si₃O₉) crystalline phase was also detected. Besides in vitro bioactivity, cytotoxicity and osteoblast adhesion and proliferation tests were applied after all characterizations, and the formulation comprising 70% glass was demonstrated to be promising for further in vivo studies.

KEYWORDS:

bioactivity; cytotoxicity; glass-ceramics; polymer-derived ceramics

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