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A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A.

Abache T, Fontayne A, Grenier D, Jacque E, Longue A, Dezetter AS, Souilliart B, Chevreux G, Bataille D, Chtourou S, Plantier JL.

Haematologica. 2019 Nov 7. pii: haematol.2019.219865. doi: 10.3324/haematol.2019.219865. [Epub ahead of print]


Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies.

Bas M, Terrier A, Jacque E, Dehenne A, Pochet-Béghin V, Beghin C, Dezetter AS, Dupont G, Engrand A, Beaufils B, Mondon P, Fournier N, de Romeuf C, Jorieux S, Fontayne A, Mars LT, Monnet C.

J Immunol. 2019 Mar 1;202(5):1582-1594. doi: 10.4049/jimmunol.1800896. Epub 2019 Jan 25.


An innovative flow cytometry method to screen human scFv-phages selected by in vivo phage-display in an animal model of atherosclerosis.

Hemadou A, Laroche-Traineau J, Antoine S, Mondon P, Fontayne A, Le Priol Y, Claverol S, Sanchez S, Cerutti M, Ottones F, Clofent-Sanchez G, Jacobin-Valat MJ.

Sci Rep. 2018 Oct 9;8(1):15016. doi: 10.1038/s41598-018-33382-2.


Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern.

Fournier N, Jacque E, Fontayne A, Derache D, Dupont G, Verhaeghe L, Baptista L, Dehenne A, Dezetter AS, Terrier A, Longue A, Pochet-Beghin V, Beghin C, Chtourou S, de Romeuf C.

MAbs. 2018 May/Jun;10(4):651-663. doi: 10.1080/19420862.2018.1451283. Epub 2018 Apr 10.


Inactivated antithombin as anticoagulant reversal in a rat model of cardiopulmonary bypass: a potent and potentially safer alternative to protamine.

Bianchini EP, Sebestyen A, Abache T, Bourti Y, Fontayne A, Richard V, Tamion F, Plantier JL, Doguet F, Borgel D.

Br J Haematol. 2018 Mar;180(5):715-720. doi: 10.1111/bjh.15091. Epub 2018 Jan 24.


The European AntibotABE Framework Program and Its Update: Development of Innovative Botulinum Antibodies.

Rasetti-Escargueil C, Avril A, Miethe S, Mazuet C, Derman Y, Selby K, Thullier P, Pelat T, Urbain R, Fontayne A, Korkeala H, Sesardic D, Hust M, Popoff MR.

Toxins (Basel). 2017 Oct 2;9(10). pii: E309. doi: 10.3390/toxins9100309. Review.


The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells.

Estupina P, Fontayne A, Barret JM, Kersual N, Dubreuil O, Le Blay M, Pichard A, Jarlier M, Pugnière M, Chauvin M, Chardès T, Pouget JP, Deshayes E, Rossignol A, Abache T, de Romeuf C, Terrier A, Verhaeghe L, Gaucher C, Prost JF, Pèlegrin A, Navarro-Teulon I.

Oncotarget. 2017 Jun 6;8(23):37061-37079. doi: 10.18632/oncotarget.15715.


Neutralization of Botulinum Neurotoxin Type E by a Humanized Antibody.

Derman Y, Selby K, Miethe S, Frenzel A, Liu Y, Rasetti-Escargueil C, Avril A, Pelat T, Urbain R, Fontayne A, Thullier P, Sesardic D, Lindström M, Hust M, Korkeala H.

Toxins (Basel). 2016 Sep 12;8(9). pii: E257. doi: 10.3390/toxins8090257.


Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B.

Miethe S, Mazuet C, Liu Y, Tierney R, Rasetti-Escargueil C, Avril A, Frenzel A, Thullier P, Pelat T, Urbain R, Fontayne A, Sesardic D, Hust M, Popoff MR.

PLoS One. 2016 Aug 25;11(8):e0161446. doi: 10.1371/journal.pone.0161446. eCollection 2016.


Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin.

Respaud R, Marchand D, Pelat T, Tchou-Wong KM, Roy CJ, Parent C, Cabrera M, Guillemain J, Mac Loughlin R, Levacher E, Fontayne A, Douziech-Eyrolles L, Junqua-Moullet A, Guilleminault L, Thullier P, Guillot-Combe E, Vecellio L, Heuzé-Vourc'h N.

J Control Release. 2016 Jul 28;234:21-32. doi: 10.1016/j.jconrel.2016.05.018. Epub 2016 May 9.


Characterization of monoclonal antibodies by a fast and easy liquid chromatography-mass spectrometry time-of-flight analysis on culture supernatant.

Henninot A, Terrier A, Charton J, Urbain R, Fontayne A, Deprez B, Beghyn T.

Anal Biochem. 2015 Dec 15;491:52-4. doi: 10.1016/j.ab.2015.08.006. Epub 2015 Aug 22.


Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions.

Monnet C, Jorieux S, Urbain R, Fournier N, Bouayadi K, De Romeuf C, Behrens CK, Fontayne A, Mondon P.

Front Immunol. 2015 Feb 4;6:39. doi: 10.3389/fimmu.2015.00039. eCollection 2015.


Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody.

Monnet C, Jorieux S, Souyris N, Zaki O, Jacquet A, Fournier N, Crozet F, de Romeuf C, Bouayadi K, Urbain R, Behrens CK, Mondon P, Fontayne A.

MAbs. 2014 Mar-Apr;6(2):422-36. doi: 10.4161/mabs.27854. Epub 2014 Jan 15.


Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0.

Teylaert B, Meurice E, Bobowski M, Harduin-Lepers A, Gaucher C, Fontayne A, Jorieux S, Delannoy P.

BMC Biotechnol. 2011 Jan 5;11:1. doi: 10.1186/1472-6750-11-1.


Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.

Salles I, Broos K, Fontayne A, Szántó T, Ruan C, Nurden AT, Vanhoorelbeke K, Deckmyn H.

Thromb Haemost. 2010 Aug;104(2):392-401. doi: 10.1160/TH09-07-0505. Epub 2010 May 27.


The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons.

Fontayne A, Meiring M, Lamprecht S, Roodt J, Demarsin E, Barbeaux P, Deckmyn H.

Thromb Haemost. 2008 Oct;100(4):670-7.


Low expression of the beta-ENaC subunit impairs lung fluid clearance in the mouse.

Randrianarison N, Clerici C, Ferreira C, Fontayne A, Pradervand S, Fowler-Jaeger N, Hummler E, Rossier BC, Planès C.

Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L409-16. Epub 2007 Nov 16.


Inhibition of platelet glycoprotein Ib and its antithrombotic potential.

Vanhoorelbeke K, Ulrichts H, Van de Walle G, Fontayne A, Deckmyn H.

Curr Pharm Des. 2007;13(26):2684-97. Review.


Paratope and epitope mapping of the antithrombotic antibody 6B4 in complex with platelet glycoprotein Ibalpha.

Fontayne A, De Maeyer B, De Maeyer M, Yamashita M, Matsushita T, Deckmyn H.

J Biol Chem. 2007 Aug 10;282(32):23517-24. Epub 2007 Jun 14.


beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice.

Randrianarison N, Escoubet B, Ferreira C, Fontayne A, Fowler-Jaeger N, Clerici C, Hummler E, Rossier BC, Planès C.

J Physiol. 2007 Jul 15;582(Pt 2):777-88. Epub 2007 Apr 12.

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