Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 55

1.

AVN-492, A Novel Highly Selective 5-HT6R Antagonist: Preclinical Evaluation.

Ivachtchenko AV, Okun I, Aladinskiy V, Ivanenkov Y, Koryakova A, Karapetyan R, Mitkin O, Salimov R, Ivashchenko A.

J Alzheimers Dis. 2017;58(4):1043-1063. doi: 10.3233/JAD-161262.

PMID:
28550249
2.

Small-molecule inhibitors of hepatitis C virus (HCV) non-structural protein 5A (NS5A): a patent review (2010-2015).

Ivanenkov YA, Aladinskiy VA, Bushkov NA, Ayginin AA, Majouga AG, Ivachtchenko AV.

Expert Opin Ther Pat. 2017 Apr;27(4):401-414. doi: 10.1080/13543776.2017.1272573. Epub 2017 Jan 10. Review.

PMID:
27967269
3.

AVN-322 is a Safe Orally Bio-Available Potent and Highly Selective Antagonist of 5-HT6R with Demonstrated Ability to Improve Impaired Memory in Animal Models.

Ivachtchenko AV, Ivanenkov YA, Veselov MS, Okun IM.

Curr Alzheimer Res. 2017;14(3):268-294. doi: 10.2174/1567205013666161108105005.

PMID:
27829340
4.

AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders.

Ivachtchenko AV, Lavrovsky Y, Okun I.

J Alzheimers Dis. 2016 May 25;53(2):583-620. doi: 10.3233/JAD-151146. Review.

5.

AVN-211, Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist, for the Treatment of Alzheimer's Disease.

Ivachtchenko AV, Lavrovsky Y, Ivanenkov YA.

Mol Pharm. 2016 Mar 7;13(3):945-63. doi: 10.1021/acs.molpharmaceut.5b00830. Epub 2016 Feb 26.

PMID:
26886442
6.

A Comprehensive Insight into the Chemical Space and ADME Features of Small Molecule NS5A Inhibitors.

Ivanenkov YA, Veselov MS, Shakhbazyan AG, Aladinskiy VA, Aladinskaya AV, Yartseva SM, Majouga AG, Vantskul AS, Leonov SV, Ivachtchenko AV, Koteliansky VE.

Curr Top Med Chem. 2016;16(12):1372-82. Review.

PMID:
26585933
7.

In Silico Approaches to the Design of NS5A Inhibitors.

Ivanenkov YA, Veselov MS, Aladinskiy VA, Shakhbazyan AG, Yartseva SM, Majouga AG, Aladinskaya AV, Vantskul AS, Leonov SV, Ivachtchenko AV, Koteliansky VE.

Curr Top Med Chem. 2016;16(12):1383-91. Review.

PMID:
26585932
8.

Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Vorobiev AA, Kuznetsova IV, Shevkun NA, Koryakova AG, Karapetian RN, Trifelenkov AS, Kravchenko DV, Veselov MS, Chufarova NV.

Eur J Med Chem. 2015 Jun 24;99:51-66. doi: 10.1016/j.ejmech.2015.05.039. Epub 2015 Jun 2.

PMID:
26046313
9.

Non-dopamine receptor ligands for the treatment of Parkinson's disease. Insight into the related chemical/property space.

Ivanenkov YA, Veselov MS, Chufarova NV, Majouga AG, Kudryavceva AA, Ivachtchenko AV.

Mol Divers. 2016 Feb;20(1):345-65. doi: 10.1007/s11030-015-9598-y. Epub 2015 May 9. Review.

PMID:
25956815
10.

Discovery of novel highly potent hepatitis C virus NS5A inhibitor (AV4025).

Ivachtchenko AV, Mitkin OD, Yamanushkin PM, Kuznetsova IV, Bulanova EA, Shevkun NA, Koryakova AG, Karapetian RN, Bichko VV, Trifelenkov AS, Kravchenko DV, Vostokova NV, Veselov MS, Chufarova NV, Ivanenkov YA.

J Med Chem. 2014 Sep 25;57(18):7716-30. doi: 10.1021/jm500951r. Epub 2014 Sep 9.

PMID:
25148100
11.

Novel oral anti-influenza drug candidate AV5080.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Yamanushkin PM, Bichko VV, Shevkun NA, Karapetian RN, Leneva IA, Borisova OV, Veselov MS.

J Antimicrob Chemother. 2014 Jul;69(7):1892-902. doi: 10.1093/jac/dku074. Epub 2014 Apr 11.

PMID:
24729605
12.

Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment.

Ivachtchenko AV, Mitkin OD, Kudan EV, Rjahovsky AA, Vorobiev AA, Trifelenkov AS, Shevkun NA, Proskurina OV, Kravchenko DV, Karapetian RN.

J Cancer. 2014 Jan 21;5(2):133-42. doi: 10.7150/jca.7773. eCollection 2014.

13.

Novel oral anti-influenza prodrug candidate AV5075S.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Yamanushkin PM, Bichko VV, Shevkun NA, Mokrushina OV, Nevolina OO, Karapetian RN, Leneva IA, Fedyakina IT, Veselov MS.

J Antimicrob Chemother. 2014 May;69(5):1311-24. doi: 10.1093/jac/dkt507. Epub 2014 Jan 15.

PMID:
24428978
14.

A novel influenza virus neuraminidase inhibitor AV5027.

Ivachtchenko AV, Ivanenkov YA, Mitkin OD, Yamanushkin PM, Bichko VV, Leneva IA, Borisova OV.

Antiviral Res. 2013 Dec;100(3):698-708.

PMID:
24416774
15.

Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study.

Morozova MA, Lepilkina TA, Rupchev GE, Beniashvily AG, Burminskiy DS, Potanin SS, Bondarenko EV, Kazey VI, Lavrovsky Y, Ivachtchenko AV.

CNS Spectr. 2014 Aug;19(4):316-23. doi: 10.1017/S1092852913000394. Epub 2013 Jun 17.

PMID:
23768250
16.

5-HT(6) receptor modulators: a patent update. Part 2. Diversity in heterocyclic scaffolds.

Ivachtchenko AV, Ivanenkov YA, Skorenko AV.

Expert Opin Ther Pat. 2012 Oct;22(10):1123-68. Epub 2012 Sep 7. Review.

PMID:
22957857
17.

5HT(6) receptor antagonists: a patent update. Part 1. Sulfonyl derivatives.

Ivachtchenko AV, Ivanenkov YA.

Expert Opin Ther Pat. 2012 Aug;22(8):917-64. doi: 10.1517/13543776.2012.709236. Review.

PMID:
22816965
18.

Antagonists of 5-HT₆ receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Vorobiev AA, Okun I.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4273-80. doi: 10.1016/j.bmcl.2012.05.036. Epub 2012 May 17.

PMID:
22664127
19.

Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM.

J Med Chem. 2011 Dec 8;54(23):8161-73. doi: 10.1021/jm201079g. Epub 2011 Nov 10.

PMID:
22029285
20.

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Mitkin OD, Tkachenko SE, Kysil VM, Okun I.

Eur J Med Chem. 2011 Apr;46(4):1189-97. doi: 10.1016/j.ejmech.2011.01.038. Epub 2011 Feb 1.

PMID:
21333408

Supplemental Content

Loading ...
Support Center