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Items: 17

1.

Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.

Kovaleva K, Oleshko O, Mamontova E, Yarovaya O, Zakharova O, Zakharenko A, Kononova A, Dyrkheeva N, Cheresiz S, Pokrovsky A, Lavrik O, Salakhutdinov N.

J Nat Prod. 2019 Aug 20. doi: 10.1021/acs.jnatprod.8b01095. [Epub ahead of print]

PMID:
31430155
2.

Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.

Zakharenko A, Dyrkheeva N, Lavrik O.

Med Res Rev. 2019 Jul;39(4):1427-1441. doi: 10.1002/med.21587. Epub 2019 Apr 19. Review.

PMID:
31004352
3.

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

Mozhaitsev ES, Zakharenko AL, Suslov EV, Korchagina DV, Zakharova OD, Vasil'eva IA, Chepanova AA, Black E, Patel J, Chand R, Reynisson J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI.

Anticancer Agents Med Chem. 2019;19(4):463-472. doi: 10.2174/1871520619666181207094243.

PMID:
30523770
4.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Li-Zhulanov NS, Zakharenko AL, Chepanova AA, Patel J, Zafar A, Volcho KP, Salakhutdinov NF, Reynisson J, Leung IKH, Lavrik OI.

Molecules. 2018 Sep 26;23(10). pii: E2468. doi: 10.3390/molecules23102468.

5.

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy.

Komarova AO, Drenichev MS, Dyrkheeva NS, Kulikova IV, Oslovsky VE, Zakharova OD, Zakharenko AL, Mikhailov SN, Lavrik OI.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1415-1429. doi: 10.1080/14756366.2018.1509210.

6.

Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1.

Dyrkheeva N, Luzina O, Filimonov A, Zakharova O, Ilina E, Zakharenko A, Kuprushkin M, Nilov D, Gushchina I, Švedas V, Salakhutdinov N, Lavrik O.

Planta Med. 2019 Jan;85(2):103-111. doi: 10.1055/a-0681-7069. Epub 2018 Aug 24.

PMID:
30142660
7.

Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.

Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O.

Bioorg Med Chem. 2018 Aug 15;26(15):4470-4480. doi: 10.1016/j.bmc.2018.07.039. Epub 2018 Jul 24.

PMID:
30076000
8.

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

Salomatina OV, Popadyuk II, Zakharenko AL, Zakharova OD, Fadeev DS, Komarova NI, Reynisson J, Arabshahi HJ, Chand R, Volcho KP, Salakhutdinov NF, Lavrik OI.

Molecules. 2018 Mar 17;23(3). pii: E679. doi: 10.3390/molecules23030679.

9.

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

Ponomarev KY, Suslov EV, Zakharenko AL, Zakharova OD, Rogachev AD, Korchagina DV, Zafar A, Reynisson J, Nefedov AA, Volcho KP, Salakhutdinov NF, Lavrik OI.

Bioorg Chem. 2018 Feb;76:392-399. doi: 10.1016/j.bioorg.2017.12.005. Epub 2017 Dec 9.

PMID:
29248742
10.

Genomes of Novel Microbial Lineages Assembled from the Sub-Ice Waters of Lake Baikal.

Cabello-Yeves PJ, Zemskaya TI, Rosselli R, Coutinho FH, Zakharenko AS, Blinov VV, Rodriguez-Valera F.

Appl Environ Microbiol. 2017 Dec 15;84(1). pii: e02132-17. doi: 10.1128/AEM.02132-17. Print 2018 Jan 1.

11.

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

Zakharenko A, Luzina O, Koval O, Nilov D, Gushchina I, Dyrkheeva N, Švedas V, Salakhutdinov N, Lavrik O.

J Nat Prod. 2016 Nov 23;79(11):2961-2967. Epub 2016 Nov 14.

PMID:
27933897
12.

A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors.

Sherstyuk YV, Zakharenko AL, Kutuzov MM, Chalova PV, Sukhanova MV, Lavrik OI, Silnikov VN, Abramova TV.

Mol Divers. 2017 Feb;21(1):101-113. doi: 10.1007/s11030-016-9703-x. Epub 2016 Sep 27.

PMID:
27677737
13.

New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties.

Khomenko T, Zakharenko A, Odarchenko T, Arabshahi HJ, Sannikova V, Zakharova O, Korchagina D, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O.

Bioorg Med Chem. 2016 Nov 1;24(21):5573-5581. doi: 10.1016/j.bmc.2016.09.016. Epub 2016 Sep 13.

PMID:
27658793
14.

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.

Zakharenko A, Khomenko T, Zhukova S, Koval O, Zakharova O, Anarbaev R, Lebedeva N, Korchagina D, Komarova N, Vasiliev V, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O.

Bioorg Med Chem. 2015 May 1;23(9):2044-52. doi: 10.1016/j.bmc.2015.03.020. Epub 2015 Mar 12.

PMID:
25819333
15.

Disaccharide pyrimidine nucleosides and their derivatives: a novel group of cell-penetrating inhibitors of poly(ADP-ribose) polymerase 1.

Efremova AS, Zakharenko AL, Shram SI, Kulikova IV, Drenichev MS, Sukhanova MV, Khodyreva SN, Myasoedov NF, Lavrik OI, Mikhailov SN.

Nucleosides Nucleotides Nucleic Acids. 2013;32(9):510-28. doi: 10.1080/15257770.2013.827793.

PMID:
24079274
16.

Influence of usnic acid and its derivatives on the activity of mammalian poly(ADP-ribose)polymerase 1 and DNA polymerase β.

Zakharenko A, Sokolov D, Luzina O, Sukhanova M, Khodyreva S, Zakharova O, Salakhutdinov N, Lavrik O.

Med Chem. 2012 Sep;8(5):883-93.

PMID:
22741606
17.

Hit clustering can improve virtual fragment screening: CDK2 and PARP1 case studies.

Zeifman AA, Stroylov VS, Novikov FN, Stroganov OV, Zakharenko AL, Khodyreva SN, Lavrik OI, Chilov GG.

J Mol Model. 2012 Jun;18(6):2553-66. doi: 10.1007/s00894-011-1280-4. Epub 2011 Nov 9.

PMID:
22069029

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