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Items: 1 to 20 of 46

1.

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block.

Xian W, Hui X, Tian Q, Wang H, Moretti A, Laugwitz KL, Flockerzi V, Ruppenthal S, Lipp P.

Cell Rep. 2018 Jul 17;24(3):724-731. doi: 10.1016/j.celrep.2018.06.034.

2.

Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.

Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.

EMBO J. 2018 Jun 15;37(12). pii: e98133. doi: 10.15252/embj.201798133. Epub 2018 May 15.

3.

Suppression of Arrhythmia by Enhancing Mitochondrial Ca2+ Uptake in Catecholaminergic Ventricular Tachycardia Models.

Schweitzer MK, Wilting F, Sedej S, Dreizehnter L, Dupper NJ, Tian Q, Moretti A, My I, Kwon O, Priori SG, Laugwitz KL, Storch U, Lipp P, Breit A, Mederos Y Schnitzler M, Gudermann T, Schredelseker J.

JACC Basic Transl Sci. 2017 Dec;2(6):737-747. doi: 10.1016/j.jacbts.2017.06.008. Epub 2017 Nov 8.

4.

Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research.

Goedel A, My I, Sinnecker D, Moretti A.

Curr Cardiol Rep. 2017 Mar;19(3):23. doi: 10.1007/s11886-017-0828-z. Review.

PMID:
28220464
5.

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.

Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.

6.

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

Rocchetti M, Sala L, Dreizehnter L, Crotti L, Sinnecker D, Mura M, Pane LS, Altomare C, Torre E, Mostacciuolo G, Severi S, Porta A, De Ferrari GM, George AL Jr, Schwartz PJ, Gnecchi M, Moretti A, Zaza A.

Cardiovasc Res. 2017 Apr 1;113(5):531-541. doi: 10.1093/cvr/cvx006.

PMID:
28158429
7.

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz KL, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C.

J Am Coll Cardiol. 2017 Jan 17;69(2):131-143. doi: 10.1016/j.jacc.2016.10.058.

8.

Efficacy and safety of sofosbuvir/simeprevir plus flat dose ribavirin in genotype 1 elderly cirrhotic patients: A real-life study.

Pellicelli AM, Pace Palitti V, Vignally P, Ceccherini-Silberstein F, Siciliano M, Giannelli V, Moretti A, Tarquini P, Scifo G, Messina V, Ascione A, Izzi A, Marignani M, D'Ambrosio C, Fondacaro L, Ettorre GM, Ialongo P, Sacco R, Perno CF, Barbarini G; CLEO Group.

Liver Int. 2017 May;37(5):653-661. doi: 10.1111/liv.13288. Epub 2016 Dec 15.

PMID:
27782373
9.

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.

Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M.

EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260. Print 2016 Sep.

10.

[Diverticular disease: towards 2020. An evidence-based approach].

Koch M, Festa V, Chiesara F, Moretti A, Bianchi M, Dezi A.

Recenti Prog Med. 2016 Jun;107(6):309-19. doi: 10.1701/2296.24692. Italian.

PMID:
27362723
11.

Human Engineered Heart Tissue: Analysis of Contractile Force.

Mannhardt I, Breckwoldt K, Letuffe-Brenière D, Schaaf S, Schulz H, Neuber C, Benzin A, Werner T, Eder A, Schulze T, Klampe B, Christ T, Hirt MN, Huebner N, Moretti A, Eschenhagen T, Hansen A.

Stem Cell Reports. 2016 Jul 12;7(1):29-42. doi: 10.1016/j.stemcr.2016.04.011. Epub 2016 May 19.

12.

Genetically Encoded Voltage Indicators in Circulation Research.

Kaestner L, Tian Q, Kaiser E, Xian W, Müller A, Oberhofer M, Ruppenthal S, Sinnecker D, Tsutsui H, Miyawaki A, Moretti A, Lipp P.

Int J Mol Sci. 2015 Sep 8;16(9):21626-42. doi: 10.3390/ijms160921626. Review.

13.

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

Gramlich M, Pane LS, Zhou Q, Chen Z, Murgia M, Schötterl S, Goedel A, Metzger K, Brade T, Parrotta E, Schaller M, Gerull B, Thierfelder L, Aartsma-Rus A, Labeit S, Atherton JJ, McGaughran J, Harvey RP, Sinnecker D, Mann M, Laugwitz KL, Gawaz MP, Moretti A.

EMBO Mol Med. 2015 May;7(5):562-76. doi: 10.15252/emmm.201505047.

14.

Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.

Orban M, Goedel A, Haas J, Sandrock-Lang K, Gärtner F, Jung CB, Zieger B, Parrotta E, Kurnik K, Sinnecker D, Wanner G, Laugwitz KL, Massberg S, Moretti A.

PLoS One. 2015 Jan 21;10(1):e0115978. doi: 10.1371/journal.pone.0115978. eCollection 2015.

15.

Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity.

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A.

Stem Cells. 2015 Apr;33(4):1113-29. doi: 10.1002/stem.1923.

16.

Live fluorescent RNA-based detection of pluripotency gene expression in embryonic and induced pluripotent stem cells of different species.

Lahm H, Doppler S, Dreßen M, Werner A, Adamczyk K, Schrambke D, Brade T, Laugwitz KL, Deutsch MA, Schiemann M, Lange R, Moretti A, Krane M.

Stem Cells. 2015 Feb;33(2):392-402. doi: 10.1002/stem.1872.

17.

Extending human induced pluripotent stem cell technology to infectious diseases: new model for viral myocarditis.

Sinnecker D, Laugwitz KL, Moretti A.

Circ Res. 2014 Aug 29;115(6):537-9. doi: 10.1161/CIRCRESAHA.114.304786. No abstract available.

PMID:
25170088
18.

Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing.

Sinnecker D, Laugwitz KL, Moretti A.

Pharmacol Ther. 2014 Aug;143(2):246-52. doi: 10.1016/j.pharmthera.2014.03.004. Epub 2014 Mar 19. Review.

19.

A case of hepatocellular carcinoma: spontaneous regression?

Chiesara F, Spagnolo A, Koch M, Moretti A.

Dig Liver Dis. 2014 Jul;46(7):659-60. doi: 10.1016/j.dld.2014.02.007. Epub 2014 Mar 13. No abstract available.

PMID:
24631030
20.

Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.

Stoehr A, Neuber C, Baldauf C, Vollert I, Friedrich FW, Flenner F, Carrier L, Eder A, Schaaf S, Hirt MN, Aksehirlioglu B, Tong CW, Moretti A, Eschenhagen T, Hansen A.

Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1353-63. doi: 10.1152/ajpheart.00705.2013. Epub 2014 Feb 28.

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