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Items: 1 to 20 of 41

1.

Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one Derivatives and Study of Their Antiviral Activity against Parvovirus B19.

Conti I, Morigi R, Locatelli A, Rambaldi M, Bua G, Gallinella G, Leoni A.

Molecules. 2019 Mar 15;24(6). pii: E1037. doi: 10.3390/molecules24061037.

2.

4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching.

Leoni A, Frosini M, Locatelli A, Micucci M, Carotenuto C, Durante M, Cosconati S, Budriesi R.

Eur J Med Chem. 2019 May 1;169:89-102. doi: 10.1016/j.ejmech.2019.02.075. Epub 2019 Mar 4.

PMID:
30861492
3.

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

Morigi R, Locatelli A, Leoni A, Rambaldi M, Bortolozzi R, Mattiuzzo E, Ronca R, Maccarinelli F, Hamel E, Bai R, Brancale A, Viola G.

Eur J Med Chem. 2019 Mar 15;166:514-530. doi: 10.1016/j.ejmech.2019.01.049. Epub 2019 Jan 26.

PMID:
30784885
4.

Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora.

Morigi R, Vitali B, Prata C, Palomino RAN, Graziadio A, Locatelli A, Rambaldi M, Leoni A.

Med Chem. 2018;14(3):311-319. doi: 10.2174/1573406413666171010110819.

PMID:
29032761
5.

Small-Molecules Targeting Kinases Involved in Pulmonary Hypertension: a Patent Review (2010-2015).

Morigi R, Rambaldi M, Locatelli A, Leoni A.

Curr Med Chem. 2016;23(30):3510-3527. Review.

PMID:
27516199
6.

Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives.

Amato J, Morigi R, Pagano B, Pagano A, Ohnmacht S, De Magis A, Tiang YP, Capranico G, Locatelli A, Graziadio A, Leoni A, Rambaldi M, Novellino E, Neidle S, Randazzo A.

J Med Chem. 2016 Jun 23;59(12):5706-20. doi: 10.1021/acs.jmedchem.6b00129. Epub 2016 Jun 6.

PMID:
27223049
7.

2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2016;26(2):149-73. doi: 10.1517/13543776.2016.1118059. Epub 2015 Dec 4. Review.

PMID:
26561198
8.

Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity.

Morigi R, Locatelli A, Leoni A, Rambaldi M.

Recent Pat Anticancer Drug Discov. 2015;10(3):280-97. Review.

PMID:
26152151
9.

Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives.

Kumar S, Gopalakrishnan V, Hegde M, Rana V, Dhepe SS, Ramareddy SA, Leoni A, Locatelli A, Morigi R, Rambaldi M, Srivastava M, Raghavan SC, Karki SS.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4682-4688. doi: 10.1016/j.bmcl.2014.08.032. Epub 2014 Aug 26.

PMID:
25205189
10.

Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex.

Amato J, Iaccarino N, Pagano B, Morigi R, Locatelli A, Leoni A, Rambaldi M, Zizza P, Biroccio A, Novellino E, Randazzo A.

Front Chem. 2014 Jul 24;2:54. doi: 10.3389/fchem.2014.00054. eCollection 2014.

11.

Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells.

Leoni A, Locatelli A, Morigi R, Rambaldi M, Cappadone C, Farruggia G, Iotti S, Merolle L, Zini M, Stefanelli C.

Eur J Med Chem. 2014 May 22;79:382-90. doi: 10.1016/j.ejmech.2014.04.004. Epub 2014 Apr 3.

PMID:
24747749
12.

Novel thiazole derivatives: a patent review (2008 - 2012. Part 2).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2014 Jul;24(7):759-77. doi: 10.1517/13543776.2014.910196. Epub 2014 Apr 19. Review.

PMID:
24745553
13.

Novel thiazole derivatives: a patent review (2008 - 2012; Part 1).

Leoni A, Locatelli A, Morigi R, Rambaldi M.

Expert Opin Ther Pat. 2014 Feb;24(2):201-16. doi: 10.1517/13543776.2014.858121. Epub 2013 Nov 12. Review.

PMID:
24215328
14.

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.

Andreani A, Leoni A, Locatelli A, Morigi R, Rambaldi M, Cervellati R, Greco E, Kondratyuk TP, Park EJ, Huang K, van Breemen RB, Pezzuto JM.

Eur J Med Chem. 2013 Oct;68:412-21. doi: 10.1016/j.ejmech.2013.07.052. Epub 2013 Aug 13.

PMID:
23994869
15.

Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)-1,3-dihydroindol-2-ones and studies on their mechanisms of action.

Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Vieceli Dalla Sega F, Prata C, Nguyen TL, Bai R, Hamel E.

Eur J Med Chem. 2013 Jun;64:603-12. doi: 10.1016/j.ejmech.2013.03.033. Epub 2013 Apr 3.

16.

Ligand based approach to L-type calcium channel by imidazo[2,1-b]thiazole-1,4-dihydropyridines: from heart activity to brain affinity.

Locatelli A, Cosconati S, Micucci M, Leoni A, Marinelli L, Bedini A, Ioan P, Spampinato SM, Novellino E, Chiarini A, Budriesi R.

J Med Chem. 2013 May 23;56(10):3866-77. doi: 10.1021/jm301839q. Epub 2013 May 9.

PMID:
23586669
17.

Intracellular magnesium content decreases during mitochondria-mediated apoptosis induced by a new indole-derivative in human colon cancer cells.

Cappadone C, Merolle L, Marraccini C, Farruggia G, Sargenti A, Locatelli A, Morigi R, Iotti S.

Magnes Res. 2012 Jul-Sep;25(3):104-11. doi: 10.1684/mrh.2012.0319.

18.

Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

Andreani A, Granaiola M, Locatelli A, Morigi R, Rambaldi M, Varoli L, Calonghi N, Cappadone C, Farruggia G, Stefanelli C, Masotti L, Nguyen TL, Hamel E, Shoemaker RH.

J Med Chem. 2012 Mar 8;55(5):2078-88. doi: 10.1021/jm2012694. Epub 2012 Feb 15.

19.

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors.

Andreani A, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Varoli L, Lannigan D, Smith J, Scudiero D, Kondapaka S, Shoemaker RH.

Eur J Med Chem. 2011 Sep;46(9):4311-23. doi: 10.1016/j.ejmech.2011.07.001. Epub 2011 Jul 8.

PMID:
21794960
20.

Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines.

Budriesi R, Ioan P, Leoni A, Pedemonte N, Locatelli A, Micucci M, Chiarini A, Galietta LJ.

J Med Chem. 2011 Jun 9;54(11):3885-94. doi: 10.1021/jm200199r. Epub 2011 May 13.

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