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A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.

Akoume MY, Elbakry M, Veillette M, Franco A, Nada D, Labelle H, Mac-Thiong JM, Grimard G, Ouellet J, Parent S, Rivard CH, Lombardi G, Colombini A, Banfi G, Brayda-Bruno M, Gorman KF, Moreau A.

Sci Rep. 2019 Jul 11;9(1):10074. doi: 10.1038/s41598-019-46325-2.


Intra-Articular Injection of Hydrolyzed Collagen to Treat Symptoms of Knee Osteoarthritis. A Functional In Vitro Investigation and a Pilot Retrospective Clinical Study.

De Luca P, Colombini A, Carimati G, Beggio M, de Girolamo L, Volpi P.

J Clin Med. 2019 Jul 4;8(7). pii: E975. doi: 10.3390/jcm8070975.


miR-22-5p and miR-29a-5p Are Reliable Reference Genes for Analyzing Extracellular Vesicle-Associated miRNAs in Adipose-Derived Mesenchymal Stem Cells and Are Stable under Inflammatory Priming Mimicking Osteoarthritis Condition.

Ragni E, Perucca Orfei C, De Luca P, Viganò M, Colombini A, Lugano G, Bollati V, de Girolamo L.

Stem Cell Rev. 2019 Jun 3. doi: 10.1007/s12015-019-09899-y. [Epub ahead of print]


Insights into Inflammatory Priming of Adipose-Derived Mesenchymal Stem Cells: Validation of Extracellular Vesicles-Embedded miRNA Reference Genes as A Crucial Step for Donor Selection.

Ragni E, De Luca P, Perucca Orfei C, Colombini A, Viganò M, Lugano G, Bollati V, de Girolamo L.

Cells. 2019 Apr 23;8(4). pii: E369. doi: 10.3390/cells8040369.


Human Diseased Articular Cartilage Contains a Mesenchymal Stem Cell-Like Population of Chondroprogenitors with Strong Immunomodulatory Responses.

De Luca P, Kouroupis D, Viganò M, Perucca-Orfei C, Kaplan L, Zagra L, de Girolamo L, Correa D, Colombini A.

J Clin Med. 2019 Mar 28;8(4). pii: E423. doi: 10.3390/jcm8040423.


Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes.

Ragni E, Perucca Orfei C, De Luca P, Lugano G, Viganò M, Colombini A, Valli F, Zacchetti D, Bollati V, de Girolamo L.

Stem Cell Res Ther. 2019 Mar 29;10(1):109. doi: 10.1186/s13287-019-1215-z.


Identification of miRNA Reference Genes in Extracellular Vesicles from Adipose Derived Mesenchymal Stem Cells for Studying Osteoarthritis.

Ragni E, Perucca Orfei C, De Luca P, Colombini A, Viganò M, Lugano G, Bollati V, de Girolamo L.

Int J Mol Sci. 2019 Mar 5;20(5). pii: E1108. doi: 10.3390/ijms20051108.


In Vitro Induction of Tendon-Specific Markers in Tendon Cells, Adipose- and Bone Marrow-Derived Stem Cells is Dependent on TGFβ3, BMP-12 and Ascorbic Acid Stimulation.

Perucca Orfei C, Viganò M, Pearson JR, Colombini A, De Luca P, Ragni E, Santos-Ruiz L, de Girolamo L.

Int J Mol Sci. 2019 Jan 3;20(1). pii: E149. doi: 10.3390/ijms20010149.


Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair.

Viganò M, Tessaro I, Trovato L, Colombini A, Scala M, Magi A, Toto A, Peretti G, de Girolamo L.

J Orthop Surg Res. 2018 Nov 6;13(1):279. doi: 10.1186/s13018-018-0983-y.


Silk/Fibroin Microcarriers for Mesenchymal Stem Cell Delivery: Optimization of Cell Seeding by the Design of Experiment.

Perucca Orfei C, Talò G, Viganò M, Perteghella S, Lugano G, Fabro Fontana F, Ragni E, Colombini A, De Luca P, Moretti M, Torre ML, de Girolamo L.

Pharmaceutics. 2018 Oct 24;10(4). pii: E200. doi: 10.3390/pharmaceutics10040200.


Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences.

Lopa S, Colombini A, Moretti M, de Girolamo L.

Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):2003-2020. doi: 10.1007/s00167-018-5118-9. Epub 2018 Aug 29. Review.


Vitamin D's Effect on the Proliferation and Inflammation of Human Intervertebral Disc Cells in Relation to the Functional Vitamin D Receptor Gene FokI Polymorphism.

De Luca P, de Girolamo L, Perucca Orfei C, Viganò M, Cecchinato R, Brayda-Bruno M, Colombini A.

Int J Mol Sci. 2018 Jul 9;19(7). pii: E2002. doi: 10.3390/ijms19072002.


Validation of reference and identity-defining genes in human mesenchymal stem cells cultured under unrelated fetal bovine serum batches for basic science and clinical application.

Banfi F, Colombini A, Perucca Orfei C, Parazzi V, Ragni E.

Stem Cell Rev. 2018 Dec;14(6):837-846. doi: 10.1007/s12015-018-9822-0.


Housekeeping Gene Stability in Human Mesenchymal Stem and Tendon Cells Exposed to Tenogenic Factors.

Viganò M, Perucca Orfei C, de Girolamo L, Pearson JR, Ragni E, De Luca P, Colombini A.

Tissue Eng Part C Methods. 2018 Jun;24(6):360-367. doi: 10.1089/ten.TEC.2017.0518. Epub 2018 May 16.


High Levels of Circulating Type II Collagen Degradation Marker (CTx-II) Are Associated with Specific VDR Polymorphisms in Patients with Adult Vertebral Osteochondrosis.

Cauci S, Viganò M, de Girolamo L, De Luca P, Perucca Orfei C, Banfi G, Lombardi G, Brayda-Bruno M, Colombini A.

Int J Mol Sci. 2017 Sep 29;18(10). pii: E2073. doi: 10.3390/ijms18102073.


Plasma vitamin D and osteo-cartilaginous markers in Italian males affected by intervertebral disc degeneration: Focus on seasonal and pathological trend of type II collagen degradation.

Brayda-Bruno M, Viganò M, Cauci S, Vitale JA, de Girolamo L, De Luca P, Lombardi G, Banfi G, Colombini A.

Clin Chim Acta. 2017 Aug;471:87-93. doi: 10.1016/j.cca.2017.05.028. Epub 2017 May 22.


BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR) and Association with Lumbar Spine Pathologies: An Italian Case-Control Study.

Colombini A, Brayda-Bruno M, Lombardi G, Croiset SJ, Ceriani C, Buligan C, Barbina M, Banfi G, Cauci S.

PLoS One. 2016 May 5;11(5):e0155004. doi: 10.1371/journal.pone.0155004. eCollection 2016.


Interplay between low plasma RANKL and VDR-FokI polymorphism in lumbar disc herniation independently from age, body mass, and environmental factors: a case-control study in the Italian population.

Sansoni V, Perego S, Colombini A, Banfi G, Brayda-Bruno M, Lombardi G.

Eur Spine J. 2016 Jan;25(1):192-9. doi: 10.1007/s00586-015-4176-7. Epub 2015 Aug 11.


Chondrogenic capability of osteoarthritic chondrocytes from the trapeziometacarpal and hip joints.

Lovati AB, Colombini A, Recordati C, Ceriani C, Zagra L, Berzero G, Moretti M.

Cell Tissue Bank. 2016 Mar;17(1):171-7. doi: 10.1007/s10561-015-9519-4. Epub 2015 Jul 7.


Gender differences in the VDR-FokI polymorphism and conventional non-genetic risk factors in association with lumbar spine pathologies in an Italian case-control study.

Colombini A, Brayda-Bruno M, Ferino L, Lombardi G, Maione V, Banfi G, Cauci S.

Int J Mol Sci. 2015 Feb 9;16(2):3722-39. doi: 10.3390/ijms16023722.

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