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Items: 9


Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors.

Krzyscik MA, Zakrzewska M, Sørensen V, Sokolowska-Wedzina A, Lobocki M, Swiderska KW, Krowarsch D, Wiedlocha A, Otlewski J.

ACS Omega. 2017 Jul 31;2(7):3792-3805. doi: 10.1021/acsomega.7b00116. Epub 2017 Jul 21.


Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers.

Borek A, Sokolowska-Wedzina A, Chodaczek G, Otlewski J.

PLoS One. 2018 Feb 8;13(2):e0192194. doi: 10.1371/journal.pone.0192194. eCollection 2018.


Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1.

Sochaj-Gregorczyk AM, Ludzia P, Kozdrowska E, Jakimowicz P, Sokolowska-Wedzina A, Otlewski J.

Int J Mol Sci. 2017 Aug 3;18(8). pii: E1688. doi: 10.3390/ijms18081688.


Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity.

Opaliński Ł, Sokołowska-Wędzina A, Szczepara M, Zakrzewska M, Otlewski J.

Sci Rep. 2017 Aug 2;7(1):7121. doi: 10.1038/s41598-017-07479-z.


The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding.

Opalinski L, Szczepara M, Sokolowska-Wedzina A, Zakrzewska M, Otlewski J.

Int J Biochem Cell Biol. 2017 Aug;89:193-198. doi: 10.1016/j.biocel.2017.06.015. Epub 2017 Jun 23.


High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.

Lobocki M, Zakrzewska M, Szlachcic A, Krzyscik MA, Sokolowska-Wedzina A, Otlewski J.

Bioconjug Chem. 2017 Jul 19;28(7):1850-1858. doi: 10.1021/acs.bioconjchem.7b00158. Epub 2017 Jun 23.


High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer.

Sokolowska-Wedzina A, Chodaczek G, Chudzian J, Borek A, Zakrzewska M, Otlewski J.

Mol Cancer Res. 2017 Aug;15(8):1040-1050. doi: 10.1158/1541-7786.MCR-16-0136. Epub 2017 May 8.


Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule.

Petters E, Sokolowska-Wedzina A, Otlewski J.

Int J Mol Sci. 2015 Aug 21;16(8):19920-35. doi: 10.3390/ijms160819920.


Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells.

Sokolowska-Wedzina A, Borek A, Chudzian J, Jakimowicz P, Zakrzewska M, Otlewski J.

Protein Expr Purif. 2014 Jul;99:50-7. doi: 10.1016/j.pep.2014.03.012. Epub 2014 Apr 13.


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