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Items: 11


Comparative oncology approach to drug repurposing in osteosarcoma.

Parrales A, McDonald P, Ottomeyer M, Roy A, Shoenen FJ, Broward M, Bruns T, Thamm DH, Weir SJ, Neville KA, Iwakuma T, Fulbright JM.

PLoS One. 2018 Mar 26;13(3):e0194224. doi: 10.1371/journal.pone.0194224. eCollection 2018.


The interplay between mutant p53 and the mevalonate pathway.

Parrales A, Thoenen E, Iwakuma T.

Cell Death Differ. 2018 Mar;25(3):460-470. doi: 10.1038/s41418-017-0026-y. Epub 2017 Dec 13. Review.


Unsaturated fatty acids regulate stemness of ovarian cancer cells through NF-κB.

Parrales A, Ranjan A, Iwakuma T.

Stem Cell Investig. 2017 Jun 3;4:49. doi: 10.21037/sci.2017.05.07. eCollection 2017. No abstract available.


p53 as a Regulator of Lipid Metabolism in Cancer.

Parrales A, Iwakuma T.

Int J Mol Sci. 2016 Dec 10;17(12). pii: E2074. Review.


Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression.

Iyer SV, Ranjan A, Elias HK, Parrales A, Sasaki H, Roy BC, Umar S, Tawfik OW, Iwakuma T.

Nat Commun. 2016 Nov 25;7:13561. doi: 10.1038/ncomms13561.


DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.

Parrales A, Ranjan A, Iyer SV, Padhye S, Weir SJ, Roy A, Iwakuma T.

Nat Cell Biol. 2016 Nov;18(11):1233-1243. doi: 10.1038/ncb3427. Epub 2016 Oct 24.


Targeting Oncogenic Mutant p53 for Cancer Therapy.

Parrales A, Iwakuma T.

Front Oncol. 2015 Dec 21;5:288. doi: 10.3389/fonc.2015.00288. eCollection 2015. Review.


Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.

Iyer SV, Parrales A, Begani P, Narkar A, Adhikari AS, Martinez LA, Iwakuma T.

Oncotarget. 2016 Feb 2;7(5):5401-15. doi: 10.18632/oncotarget.6634.


Thrombin promotes the expression of Ccnd1 gene in RPE cells through the activation of converging signaling pathways.

Lee-Rivera I, López E, Parrales A, Alvarez-Arce A, López-Colomé AM.

Exp Eye Res. 2015 Oct;139:81-9. doi: 10.1016/j.exer.2015.08.001. Epub 2015 Aug 4.


ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation.

Parrales A, López E, Lee-Rivera I, López-Colomé AM.

Cell Signal. 2013 Apr;25(4):829-38. doi: 10.1016/j.cellsig.2012.12.023. Epub 2013 Jan 3.


Thrombin stimulates RPE cell proliferation by promoting c-Fos-mediated cyclin D1 expression.

Parrales A, Palma-Nicolás JP, López E, López-Colomé AM.

J Cell Physiol. 2010 Feb;222(2):302-12. doi: 10.1002/jcp.21951.


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