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Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3354-7. doi: 10.1002/anie.201107333. Epub 2012 Feb 17.

[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX.

Author information

1
Institute of Inorganic Chemistry, University of Zurich, Switzerland.

Abstract

Enhanced receptor selectivity: carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m)Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3)] (Cp=cyclopentadienyl, M=Re, (99m)Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported.

PMID:
22344779
DOI:
10.1002/anie.201107333
[Indexed for MEDLINE]

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