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Items: 1 to 20 of 47


Tandem Cross-Coupling/Spirocyclization/Mannich-Type Reactions of 3-(2-Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines.

Chen GS, Chen SJ, Luo J, Mao XY, Chan AS, Sun RW, Liu YL.

Angew Chem Int Ed Engl. 2020 Jan 7;59(2):614-621. doi: 10.1002/anie.201911614. Epub 2019 Dec 12.


Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells.

Zhou Y, Chung PY, Ma JY, Lam AK, Law S, Chan KW, Chan AS, Li X, Lam KH, Chui CH, Tang JC.

Biology (Basel). 2019 Oct 1;8(4). pii: E75. doi: 10.3390/biology8040075.


Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma.

Chung PY, Lam PL, Zhou YY, Gasparello J, Finotti A, Chilin A, Marzaro G, Gambari R, Bian ZX, Kwok WM, Wong WY, Wang X, Lam AK, Chan AS, Li X, Ma JY, Chui CH, Lam KH, Tang JC.

Cells. 2018 Oct 22;7(10). pii: E177. doi: 10.3390/cells7100177.


Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma.

Chan D, Zhou Y, Chui CH, Lam KH, Law S, Chan AS, Li X, Lam AK, Tang JCO.

Cells. 2018 Sep 20;7(10). pii: E143. doi: 10.3390/cells7100143.


Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2.

Pun IH, Chan D, Chan SH, Chung PY, Zhou YY, Law S, Lam AK, Chui CH, Chan AS, Lam KH, Tang JC.

Cancer Res Treat. 2017 Jan;49(1):219-229. doi: 10.4143/crt.2016.190. Epub 2016 Jul 18.


Recent advances in research of natural and synthetic bioactive quinolines.

Chung PY, Bian ZX, Pun HY, Chan D, Chan AS, Chui CH, Tang JC, Lam KH.

Future Med Chem. 2015;7(7):947-67. doi: 10.4155/fmc.15.34. Review.


Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue.

Lam KH, Lee KK, Gambari R, Kok SH, Kok TW, Chan AS, Bian ZX, Wong WY, Wong RS, Lau FY, Tong SW, Chan KW, Cheng CH, Chui CH, Tang JC.

Phytomedicine. 2014 May 15;21(6):877-82. doi: 10.1016/j.phymed.2014.02.005. Epub 2014 Mar 26.


Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus.

Lam KH, Gambari R, Lee KK, Chen YX, Kok SH, Wong RS, Lau FY, Cheng CH, Wong WY, Bian ZX, Chan AS, Tang JC, Chui CH.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):367-70. doi: 10.1016/j.bmcl.2013.10.072. Epub 2013 Nov 8.


Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents.

Chan SH, Chui CH, Chan SW, Kok SH, Chan D, Tsoi MY, Leung PH, Lam AK, Chan AS, Lam KH, Tang JC.

ACS Med Chem Lett. 2012 Dec 20;4(2):170-4. doi: 10.1021/ml300238z. eCollection 2013 Feb 14.


Preparation of Galipea officinalis Hancock type tetrahydroquinoline alkaloid analogues as anti-tumour agents.

Lam KH, Lee KK, Gambari R, Wong RS, Cheng GY, Tong SW, Chan KW, Lau FY, Lai PB, Wong WY, Chan AS, Kok SH, Tang JC, Chui CH.

Phytomedicine. 2013 Jan 15;20(2):166-71. doi: 10.1016/j.phymed.2012.09.026. Epub 2012 Nov 2.


The preparation of bi-functional organophosphine oxides as potential antitumor agents.

Lam KH, Chui CH, Gambari R, Wong RS, Cheng GY, Lau FY, Lai PB, Tong SW, Chan KW, Wong WY, Chan AS, Tang JC.

Eur J Med Chem. 2010 Nov;45(11):5527-30. doi: 10.1016/j.ejmech.2010.08.038. Epub 2010 Aug 24.


Comparison of the enteric mucosal immunomodulatory activity of combinations of Coptis chinensis Franch. Rhizomes and Evodia rutaecarpa (Juss.) Benth. Fruits in mice with dextran sulphate sodium-induced ulcerative colitis.

Luo Y, Zhao H, Liu Z, Ju D, He X, Xiao C, Zhong G, Chen S, Yang D, Chan AS, Lu A.

Planta Med. 2010 May;76(8):766-72. doi: 10.1055/s-0029-1240701. Epub 2009 Dec 23.


Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1.

Hau DK, Gambari R, Wong RS, Yuen MC, Cheng GY, Tong CS, Zhu GY, Leung AK, Lai PB, Lau FY, Chan AK, Wong WY, Kok SH, Cheng CH, Kan CW, Chan AS, Chui CH, Tang JC, Fong DW.

Phytomedicine. 2009 Aug;16(8):751-60. doi: 10.1016/j.phymed.2009.01.008. Epub 2009 Apr 21.


The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents.

Lam KH, Gambari R, Yuen MC, Kan CW, Chan P, Xu L, Tang W, Chui CH, Cheng GY, Wong RS, Lau FY, Tong CS, Chan AK, Lai PB, Kok SH, Cheng CH, Chan AS, Tang JC.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2266-9. doi: 10.1016/j.bmcl.2009.02.091. Epub 2009 Feb 27.


The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines.

Chan SH, Lam KH, Chui CH, Gambari R, Yuen MC, Wong RS, Cheng GY, Lau FY, Au YK, Cheng CH, Lai PB, Kan CW, Kok SH, Tang JC, Chan AS.

Eur J Med Chem. 2009 Jun;44(6):2736-40. doi: 10.1016/j.ejmech.2008.10.024. Epub 2008 Nov 5.


Process parameters and morphology in puerarin, phospholipids and their complex microparticles generation by supercritical antisolvent precipitation.

Li Y, Yang DJ, Chen SL, Chen SB, Chan AS.

Int J Pharm. 2008 Jul 9;359(1-2):35-45. doi: 10.1016/j.ijpharm.2008.03.022. Epub 2008 Mar 25.


Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines.

Kok SH, Gambari R, Chui CH, Yuen MC, Lin E, Wong RS, Lau FY, Cheng GY, Lam WS, Chan SH, Lam KH, Cheng CH, Lai PB, Yu MW, Cheung F, Tang JC, Chan AS.

Bioorg Med Chem. 2008 Apr 1;16(7):3626-31. doi: 10.1016/j.bmc.2008.02.005. Epub 2008 Feb 8.


Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods.

Li Y, Yang DJ, Chen SL, Chen SB, Chan AS.

Pharm Res. 2008 Mar;25(3):563-77. Epub 2007 Sep 8.


Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity.

Tang H, Wang XD, Wei YB, Huang SL, Huang ZS, Tan JH, An LK, Wu JY, Chan AS, Gu LQ.

Eur J Med Chem. 2008 May;43(5):973-80. Epub 2007 Jul 15.


Paradoxical proliferative potential of iron (II) sulphate on cancer cells after the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay.

Kok SH, Gambari R, Chui CH, Lau FY, Cheng GY, Lai PB, Lam WS, Chan AS, Cheng CH, Teo IT, Yu MW, Tang JC, Cheung F, Wong RS.

Int J Mol Med. 2007 Jun;19(6):971-5.


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