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Items: 1 to 20 of 125


Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW.

Molecules. 2019 Oct 6;24(19). pii: E3593. doi: 10.3390/molecules24193593. Review.


The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner.

Zhang Y, Gilmour A, Ahn YH, de la Vega L, Dinkova-Kostova AT.

Phytomedicine. 2019 Aug 5:153062. doi: 10.1016/j.phymed.2019.153062. [Epub ahead of print]


Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.

Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT.

PLoS One. 2019 Mar 13;14(3):e0213095. doi: 10.1371/journal.pone.0213095. eCollection 2019.


Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis.

Dikovskaya D, Appleton PL, Bento-Pereira C, Dinkova-Kostova AT.

Chem Res Toxicol. 2019 Mar 18;32(3):500-512. doi: 10.1021/acs.chemrestox.8b00354. Epub 2019 Mar 11.


Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.

Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S, Levonen AL, Kensler TW, Dinkova-Kostova AT.

Nat Rev Drug Discov. 2019 Apr;18(4):295-317. doi: 10.1038/s41573-018-0008-x. Review.


A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J.

Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092.


C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.

Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT.

Sci Rep. 2018 May 23;8(1):8037. doi: 10.1038/s41598-018-26269-9.


Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1.

Dayalan Naidu S, Suzuki T, Yamamoto M, Fahey JW, Dinkova-Kostova AT.

Mol Nutr Food Res. 2018 Sep;62(18):e1700908. doi: 10.1002/mnfr.201700908. Epub 2018 Jun 19. Review.


Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.


Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

Sharma RS, Harrison DJ, Kisielewski D, Cassidy DM, McNeilly AD, Gallagher JR, Walsh SV, Honda T, McCrimmon RJ, Dinkova-Kostova AT, Ashford MLJ, Dillon JF, Hayes JD.

Cell Mol Gastroenterol Hepatol. 2017 Dec 13;5(3):367-398. doi: 10.1016/j.jcmgh.2017.11.016. eCollection 2018 Mar.


KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.

Shekh-Ahmad T, Eckel R, Dayalan Naidu S, Higgins M, Yamamoto M, Dinkova-Kostova AT, Kovac S, Abramov AY, Walker MC.

Brain. 2018 May 1;141(5):1390-1403. doi: 10.1093/brain/awy071.


Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

Bartolome F, Esteras N, Martin-Requero A, Boutoleau-Bretonniere C, Vercelletto M, Gabelle A, Ber IL, Honda T, Dinkova-Kostova AT, Hardy J, Carro E, Abramov AY.

Sci Rep. 2018 Mar 1;8(1):4064. doi: 10.1038/s41598-018-22152-9.


The role of Nrf2 signaling in counteracting neurodegenerative diseases.

Dinkova-Kostova AT, Kostov RV, Kazantsev AG.

FEBS J. 2018 Oct;285(19):3576-3590. doi: 10.1111/febs.14379. Epub 2018 Jan 29. Review.


Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.

Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA.

Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4.


KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.

Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW.

Trends Food Sci Technol. 2017 Nov;69(Pt B):257-269. doi: 10.1016/j.tifs.2017.02.002. Epub 2017 Feb 16.


Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions.

Hayes JD, Dinkova-Kostova AT.

Mol Cell. 2017 Oct 5;68(1):5-7. doi: 10.1016/j.molcel.2017.09.023.


Transcription factors NRF2 and HSF1 have opposing functions in autophagy.

Dayalan Naidu S, Dikovskaya D, Gaurilcikaite E, Knatko EV, Healy ZR, Mohan H, Koh G, Laurell A, Ball G, Olagnier D, de la Vega L, Ganley IG, Talalay P, Dinkova-Kostova AT.

Sci Rep. 2017 Sep 8;7(1):11023. doi: 10.1038/s41598-017-11262-5.


Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species.

Kovac S, Dinkova Kostova AT, Herrmann AM, Melzer N, Meuth SG, Gorji A.

Int J Mol Sci. 2017 Sep 8;18(9). pii: E1935. doi: 10.3390/ijms18091935. Review.


Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS.

Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700029. Epub 2017 Jul 7. Review.


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