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Items: 1 to 20 of 117


Flavonol glycosides of Rosa multiflora regulates intestinal barrier function through inhibiting claudin expression in differentiated Caco-2 cells.

Endo S, Matsuoka T, Nishiyama T, Arai Y, Kashiwagi H, Abe N, Oyama M, Matsunaga T, Ikari A.

Nutr Res. 2019 Nov 4. pii: S0271-5317(19)30519-6. doi: 10.1016/j.nutres.2019.10.010. [Epub ahead of print]


Pathophysiological roles of autophagy and aldo-keto reductases in development of doxorubicin resistance in gastrointestinal cancer cells.

Matsunaga T, Kawabata S, Yanagihara Y, Kezuka C, Kato M, Morikawa Y, Endo S, Chen H, Iguchi K, Ikari A.

Chem Biol Interact. 2019 Dec 1;314:108839. doi: 10.1016/j.cbi.2019.108839. Epub 2019 Sep 26.


Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells.

Maruhashi R, Eguchi H, Akizuki R, Hamada S, Furuta T, Matsunaga T, Endo S, Ichihara K, Ikari A.

Sci Rep. 2019 Sep 24;9(1):13753. doi: 10.1038/s41598-019-50276-z.


Brazilian Green Propolis Rescues Oxidative Stress-Induced Mislocalization of Claudin-1 in Human Keratinocyte-Derived HaCaT Cells.

Marunaka K, Kobayashi M, Shu S, Matsunaga T, Ikari A.

Int J Mol Sci. 2019 Aug 8;20(16). pii: E3869. doi: 10.3390/ijms20163869.


Rescue of tight junctional localization of a claudin-16 mutant D97S by antimalarial medicine primaquine in Madin-Darby canine kidney cells.

Marunaka K, Fujii N, Kimura T, Furuta T, Hasegawa H, Matsunaga T, Endo S, Ikari A.

Sci Rep. 2019 Jul 4;9(1):9647. doi: 10.1038/s41598-019-46250-4.


Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11.

Endo S, Miyagi N, Matsunaga T, Ikari A.

Chem Biol Interact. 2019 May 25;305:12-20. doi: 10.1016/j.cbi.2019.03.026. Epub 2019 Mar 26.


Cyanidin Increases the Expression of Mg2+ Transport Carriers Mediated by the Activation of PPARĪ± in Colonic Epithelial MCE301 Cells.

Takashina Y, Manabe A, Tabuchi Y, Ikari A.

Nutrients. 2019 Mar 16;11(3). pii: E641. doi: 10.3390/nu11030641.


ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.

Akizuki R, Eguchi H, Endo S, Matsunaga T, Ikari A.

Biol Pharm Bull. 2019;42(2):247-254. doi: 10.1248/bpb.b18-00670.


Caffeic acid phenethyl ester potentiates gastric cancer cell sensitivity to doxorubicin and cisplatin by decreasing proteasome function.

Matsunaga T, Tsuchimura S, Azuma N, Endo S, Ichihara K, Ikari A.

Anticancer Drugs. 2019 Mar;30(3):251-259. doi: 10.1097/CAD.0000000000000715.


Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.

Manabe A, Furukawa C, Hasegawa H, Matsunaga T, Endo S, Ikari A.

J Cell Physiol. 2019 Jun;234(6):8951-8962. doi: 10.1002/jcp.27565. Epub 2018 Nov 21.


Sibutramine facilitates apoptosis and contraction of aortic smooth muscle cells through elevating production of reactive oxygen species.

Morikawa Y, Shibata A, Sasajima Y, Suenami K, Sato K, Takekoshi Y, Endo S, Ikari A, Matsunaga T.

Eur J Pharmacol. 2018 Dec 15;841:113-121. doi: 10.1016/j.ejphar.2018.10.009. Epub 2018 Oct 16.


Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells.

Eguchi H, Akizuki R, Maruhashi R, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A.

Sci Rep. 2018 Oct 11;8(1):15157. doi: 10.1038/s41598-018-33566-w.


Crosstalk between Na+,K+-ATPase and a volume-regulated anion channel in membrane microdomains of human cancer cells.

Fujii T, Shimizu T, Yamamoto S, Funayama K, Fujita K, Tabuchi Y, Ikari A, Takeshima H, Sakai H.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3792-3804. doi: 10.1016/j.bbadis.2018.09.014. Epub 2018 Sep 13.


Sodium Citrate Increases Expression and Flux of Mg2+ Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells.

Takashina Y, Manabe A, Hasegawa H, Matsunaga T, Endo S, Ikari A.

Nutrients. 2018 Sep 20;10(10). pii: E1345. doi: 10.3390/nu10101345.


Luminal Na+ homeostasis has an important role in intestinal peptide absorption in vivo.

Ishizuka N, Nakayama M, Watanabe M, Tajima H, Yamauchi Y, Ikari A, Hayashi H.

Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G799-G809. doi: 10.1152/ajpgi.00099.2018. Epub 2018 Aug 23.


Down-regulation of magnesium transporting molecule, claudin-16, as a possible cause of hypermagnesiuria with the development of tubulo-interstitial nephropathy.

Shimizu T, Takayanagi K, Iwashita T, Ikari A, Anzai N, Okazaki S, Hara H, Hatano M, Sano T, Ogawa T, Kanozawa K, Hasegawa H.

Magnes Res. 2018 Feb 1;31(1):11-23. doi: 10.1684/mrh.2018.0434.


Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells.

Sonoki H, Tanimae A, Furuta T, Endo S, Matsunaga T, Ichihara K, Ikari A.

J Nutr Biochem. 2018 Jun;56:205-214. doi: 10.1016/j.jnutbio.2018.02.016. Epub 2018 Mar 2.


Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells.

Akizuki R, Maruhashi R, Eguchi H, Kitabatake K, Tsukimoto M, Furuta T, Matsunaga T, Endo S, Ikari A.

Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):769-780. doi: 10.1016/j.bbamcr.2018.03.001. Epub 2018 Mar 7.


Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis.

Endo S, Hoshi M, Matsunaga T, Inoue T, Ichihara K, Ikari A.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):437-443. doi: 10.1016/j.bbrc.2018.02.105. Epub 2018 Feb 13.


Photoinduced Generation of Acyl Radicals from Simple Aldehydes, Access to 3-Acyl-4-arylcoumarin Derivatives, and Evaluation of Their Antiandrogenic Activities.

Kawaai K, Yamaguchi T, Yamaguchi E, Endo S, Tada N, Ikari A, Itoh A.

J Org Chem. 2018 Feb 16;83(4):1988-1996. doi: 10.1021/acs.joc.7b02933. Epub 2018 Jan 30.


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