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Items: 1 to 20 of 24

1.

A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules.

Fouda AM, Okasha RM, Alblewi FF, Mora A, Afifi TH, El-Agrody AM.

Bioorg Chem. 2019 Dec 23;95:103549. doi: 10.1016/j.bioorg.2019.103549. [Epub ahead of print]

PMID:
31887476
2.

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors.

Halawa AH, Eskandrani AA, Elgammal WE, Hassan SM, Hassan AH, Ebrahim HY, Mehany ABM, El-Agrody AM, Okasha RM.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5592. doi: 10.3390/ijms20225592.

3.

Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II.

Fouda AM, Assiri MA, Mora A, Ali TE, Afifi TH, El-Agrody AM.

Bioorg Chem. 2019 Dec;93:103289. doi: 10.1016/j.bioorg.2019.103289. Epub 2019 Sep 20.

PMID:
31586716
4.

Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene.

Alblewi FF, Okasha RM, Hritani ZM, Mohamed HM, El-Nassag MAA, Halawa AH, Mora A, Fouda AM, Assiri MA, Al-Dies AM, Afifi TH, El-Agrody AM.

Bioorg Chem. 2019 Jun;87:560-571. doi: 10.1016/j.bioorg.2019.03.059. Epub 2019 Mar 22.

PMID:
30928878
5.

Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis.

Alblewi FF, Okasha RM, Eskandrani AA, Afifi TH, Mohamed HM, Halawa AH, Fouda AM, Al-Dies AM, Mora A, El-Agrody AM.

Molecules. 2019 Mar 18;24(6). pii: E1060. doi: 10.3390/molecules24061060.

6.

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Ahmed HEA, El-Nassag MAA, Hassan AH, Okasha RM, Ihmaid S, Fouda AM, Afifi TH, Aljuhani A, El-Agrody AM.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1074-1088. doi: 10.1080/14756366.2018.1476503.

7.

Synthesis, biological activity and molecular modeling study of new Schiff bases incorporated with indole moiety.

Halawa AH, El-Gilil SMA, Bedair AH, Shaaban M, Frese M, Sewald N, Eliwa EM, El-Agrody AM.

Z Naturforsch C J Biosci. 2017 Oct 26;72(11-12):467-475. doi: 10.1515/znc-2017-0025.

PMID:
28525356
8.

Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions.

Okasha RM, Alblewi FF, Afifi TH, Naqvi A, Fouda AM, Al-Dies AM, El-Agrody AM.

Molecules. 2017 Mar 18;22(3). pii: E479. doi: 10.3390/molecules22030479.

9.

Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure-activity relationships of the 1-aryl group and 9-position.

Mohamed HM, Fouda AM, Khattab ESAEH, Agrody AME, Afifi TH.

Z Naturforsch C J Biosci. 2017 May 1;72(5-6):161-171. doi: 10.1515/znc-2016-0139.

PMID:
27831925
10.
11.

2-(4-Fluoro-benzyl-idene)propane-dinitrile: monoclinic polymorph.

El-Agrody AM, Al-Omar MA, Amr Ael-G, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 9;69(Pt 4):o515. doi: 10.1107/S1600536813006235. Print 2013 Apr 1.

12.

N'-[3-Cyano-4-(4-fluoro-phen-yl)-6-meth-oxy-4H-benzo[h]chromen-2-yl]-N,N-dimethyl-methanimidamide.

Al-Dies AA, Al-Omar MA, Amr Ael-G, El-Agrody AM, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 2;69(Pt 4):o482-3. doi: 10.1107/S1600536813005503. Print 2013 Apr 1.

13.

2-Amino-4-(4-bromo-phen-yl)-6-meth-oxy-4H-benzo[h]chromene-3-carbonitrile.

Al-Dies AA, El-Agrody AM, Al-Omar MA, Amr Ael-G, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 2;69(Pt 4):o480-1. doi: 10.1107/S1600536813005461. Print 2013 Apr 1.

14.

3-Amino-1-(4-fluoro-phen-yl)-7-meth-oxy-1H-benzo[f]chromene-2-carbonitrile.

Amr Ael-G, El-Agrody AM, Al-Omar MA, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 2;69(Pt 4):o478-9. doi: 10.1107/S1600536813005473. Print 2013 Apr 1.

15.

3-Amino-1-(4-fluoro-phen-yl)-8-meth-oxy-1H-benzo[f]chromene-2-carbonitrile.

El-Agrody AM, Al-Omar MA, Amr Ael-G, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 2;69(Pt 4):o476-7. doi: 10.1107/S160053681300545X. Print 2013 Apr 1.

16.

2-Amino-4-(4-chloro-phen-yl)-4H-chromeno[8,7-b]pyridine-3-carbonitrile.

Amr Ael-G, El-Agrody AM, Sabry NM, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 2;69(Pt 4):o462-3. doi: 10.1107/S1600536813005217. Print 2013 Apr 1.

17.

Ethyl 2-amino-4-(4-bromo-phen-yl)-6-meth-oxy-4H-benzo[h]chromene-3-carboxyl-ate.

El-Agrody AM, Fouda AM, Al-Omar MA, Amr Ael-G, Ng SW, Tiekink ER.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 1;69(Pt 3):o435-6. doi: 10.1107/S160053681300490X. Epub 2013 Feb 23.

18.

2-Amino-4-(4-fluoro-phen-yl)-6-meth-oxy-4H-benzo[h]chromene-3-carbonitrile.

Al-Dies AA, Amr AG, El-Agrody AM, Chia TS, Fun HK.

Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1934-5. doi: 10.1107/S1600536812023021. Epub 2012 May 31.

19.

Ethyl 2-amino-4-(4-fluoro-phen-yl)-6-meth-oxy-4H-benzo[h]chromene-3-carboxyl-ate.

El-Agrody AM, Al-Omar MA, Amr AG, Chia TS, Fun HK.

Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1803-4. doi: 10.1107/S1600536812021939. Epub 2012 May 19.

20.

Synthesis, reactions and antimicrobial activities of 8-ethoxycoumarin derivatives.

Mohamed HM, Abd El-Wahab AH, Ahmed KA, El-Agrody AM, Bedair AH, Eid FA, Khafagy MM.

Molecules. 2012 Jan 18;17(1):971-88. doi: 10.3390/molecules17010971.

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