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Items: 1 to 20 of 52

1.

Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds.

Farag AK, Hassan AHE, Ahn BS, Park KD, Roh EJ.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):311-324. doi: 10.1080/14756366.2019.1699554.

PMID:
31809612
2.

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors.

Halawa AH, Eskandrani AA, Elgammal WE, Hassan SM, Hassan AH, Ebrahim HY, Mehany ABM, El-Agrody AM, Okasha RM.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5592. doi: 10.3390/ijms20225592.

3.

Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.

Elkamhawy A, Youn Kim N, Hassan AHE, Park JE, Yang JE, Elsherbeny MH, Paik S, Oh KS, Lee BH, Lee MY, Shin KJ, Pae AN, Lee KT, Roh EJ.

Bioorg Chem. 2019 Nov;92:103261. doi: 10.1016/j.bioorg.2019.103261. Epub 2019 Sep 7.

PMID:
31542718
4.

Nanomedicine as a putative approach for active targeting of hepatocellular carcinoma.

Elnaggar MH, Abushouk AI, Hassan AHE, Lamloum HM, Benmelouka A, Moatamed SA, Abd-Elmegeed H, Attia S, Samir A, Amr N, Johar D, Zaky S.

Semin Cancer Biol. 2019 Aug 14. pii: S1044-579X(19)30225-1. doi: 10.1016/j.semcancer.2019.08.016. [Epub ahead of print] Review.

PMID:
31421265
5.

Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators.

Hassan AHE, Yoo SY, Lee KW, Yoon YM, Ryu HW, Jeong Y, Shin JS, Kang SY, Kim SY, Lee HH, Park BY, Lee KT, Lee YS.

Eur J Med Chem. 2019 Oct 15;180:253-267. doi: 10.1016/j.ejmech.2019.07.030. Epub 2019 Jul 9.

PMID:
31310917
6.

S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish.

Plate J, Sassen WA, Hassan AH, Lehne F, Köster RW, Kruse T.

Front Pharmacol. 2019 Apr 2;10:122. doi: 10.3389/fphar.2019.00122. eCollection 2019.

7.

EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.

Elkamhawy A, Hassan AHE, Paik S, Sup Lee Y, Lee HH, Shin JS, Lee KT, Roh EJ.

Bioorg Chem. 2019 May;86:112-118. doi: 10.1016/j.bioorg.2019.01.017. Epub 2019 Jan 12.

PMID:
30685642
8.

Antiproliferative 3-deoxysphingomyelin analogs: Design, synthesis, biological evaluation and molecular docking of pyrrolidine-based 3-deoxysphingomyelin analogs as anticancer agents.

Hassan AHE, Park HR, Yoon YM, Kim HI, Yoo SY, Lee KW, Lee YS.

Bioorg Chem. 2019 Mar;84:444-455. doi: 10.1016/j.bioorg.2018.11.040. Epub 2018 Nov 26.

PMID:
30576908
9.

23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells.

Won JH, Chung KS, Park EY, Lee JH, Choi JH, Tapondjou LA, Park HJ, Nomura M, Hassan AHE, Lee KT.

Molecules. 2018 Dec 13;23(12). pii: E3306. doi: 10.3390/molecules23123306.

10.

Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids.

Alam MM, Hassan AHE, Lee KW, Cho MC, Yang JS, Song J, Min KH, Hong J, Kim DH, Lee YS.

Bioorg Chem. 2019 Mar;84:51-62. doi: 10.1016/j.bioorg.2018.11.021. Epub 2018 Nov 19.

PMID:
30481646
11.

Fermentative hydrogen production from low-value substrates.

Hassan AHS, Mietzel T, Brunstermann R, Schmuck S, Schoth J, Küppers M, Widmann R.

World J Microbiol Biotechnol. 2018 Nov 16;34(12):176. doi: 10.1007/s11274-018-2558-9. Review.

PMID:
30446833
12.

First-in-class DAPK1/CSF1R dual inhibitors: Discovery of 3,5-dimethoxy-N-(4-(4-methoxyphenoxy)-2-((6-morpholinopyridin-3-yl)amino)pyrimidin-5-yl)benzamide as a potential anti-tauopathies agent.

Farag AK, Hassan AHE, Jeong H, Kwon Y, Choi JG, Oh MS, Park KD, Kim YK, Roh EJ.

Eur J Med Chem. 2019 Jan 15;162:161-175. doi: 10.1016/j.ejmech.2018.10.057. Epub 2018 Nov 2.

PMID:
30445265
13.

Natural products hybrids: 3,5,4'-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells.

Hassan AHE, Choi E, Yoon YM, Lee KW, Yoo SY, Cho MC, Yang JS, Kim HI, Hong JY, Shin JS, Chung KS, Lee JH, Lee KT, Lee YS.

Eur J Med Chem. 2019 Jan 1;161:559-580. doi: 10.1016/j.ejmech.2018.10.062. Epub 2018 Oct 29.

PMID:
30396104
14.

1H-NMR and 13C-NMR dataset for some oxidative metabolites of CRA13 and their analogs.

Hassan AHE, Cho MC, Kim HI, Yang JS, Park KT, Lee YS.

Data Brief. 2018 Oct 10;21:485-500. doi: 10.1016/j.dib.2018.09.069. eCollection 2018 Dec.

15.

SMARCAD1 in Breast Cancer Progression.

Arafat K, Al Kubaisy E, Sulaiman S, Karam SM, Al Natour Z, Hassan AH, Attoub S.

Cell Physiol Biochem. 2018;50(2):489-500. doi: 10.1159/000494163. Epub 2018 Oct 11.

16.

Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB2R affinity.

Hassan AHE, Cho MC, Kim HI, Yang JS, Park KT, Hwang JY, Jang CG, Park KD, Lee YS.

Bioorg Med Chem. 2018 Oct 1;26(18):5069-5078. doi: 10.1016/j.bmc.2018.09.007. Epub 2018 Sep 6.

PMID:
30217464
17.

Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators.

Elkamhawy A, Kim NY, Hassan AHE, Park JE, Yang JE, Oh KS, Lee BH, Lee MY, Shin KJ, Lee KT, Hur W, Roh EJ.

Eur J Med Chem. 2018 Sep 5;157:691-704. doi: 10.1016/j.ejmech.2018.08.020. Epub 2018 Aug 8.

PMID:
30130718
18.

Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease.

Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ.

Eur J Med Chem. 2018 Sep 5;157:268-278. doi: 10.1016/j.ejmech.2018.07.068. Epub 2018 Jul 31.

PMID:
30098482
19.

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Ahmed HEA, El-Nassag MAA, Hassan AH, Okasha RM, Ihmaid S, Fouda AM, Afifi TH, Aljuhani A, El-Agrody AM.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1074-1088. doi: 10.1080/14756366.2018.1476503.

20.

Repositioning of the antipsychotic trifluoperazine: Synthesis, biological evaluation and in silico study of trifluoperazine analogs as anti-glioblastoma agents.

Kang S, Lee JM, Jeon B, Elkamhawy A, Paik S, Hong J, Oh SJ, Paek SH, Lee CJ, Hassan AHE, Kang SS, Roh EJ.

Eur J Med Chem. 2018 May 10;151:186-198. doi: 10.1016/j.ejmech.2018.03.055. Epub 2018 Mar 23.

PMID:
29614416

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