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Items: 14

1.

Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers.

Mahdy HA, Ibrahim MK, Metwaly AM, Belal A, Mehany ABM, El-Gamal KMA, El-Sharkawy A, Elhendawy MA, Radwan MM, Elsohly MA, Eissa IH.

Bioorg Chem. 2019 Nov 12:103422. doi: 10.1016/j.bioorg.2019.103422. [Epub ahead of print]

PMID:
31812261
2.

New synthetic chitosan hybrids bearing some heterocyclic moieties with potential activity as anticancer and apoptosis inducers.

El-Naggar MM, Haneen DSA, Mehany ABM, Khalil MT.

Int J Biol Macromol. 2019 Nov 16. pii: S0141-8130(19)34360-0. doi: 10.1016/j.ijbiomac.2019.10.142. [Epub ahead of print]

PMID:
31743719
3.

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors.

Halawa AH, Eskandrani AA, Elgammal WE, Hassan SM, Hassan AH, Ebrahim HY, Mehany ABM, El-Agrody AM, Okasha RM.

Int J Mol Sci. 2019 Nov 8;20(22). pii: E5592. doi: 10.3390/ijms20225592.

4.

Design, synthesis, cytotoxicity screening and molecular docking of new 3-cyanopyridines as survivin inhibitors and apoptosis inducers.

Sabour R, Harras MF, Mehany ABM.

Bioorg Chem. 2019 Oct 11:103358. doi: 10.1016/j.bioorg.2019.103358. [Epub ahead of print]

PMID:
31679838
5.

Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors.

Eissa IH, Metwaly AM, Belal A, Mehany ABM, Ayyad RR, El-Adl K, Mahdy HA, Taghour MS, El-Gamal KMA, El-Sawah ME, Elmetwally SA, Elhendawy MA, Radwan MM, ElSohly MA.

Arch Pharm (Weinheim). 2019 Nov;352(11):e1900123. doi: 10.1002/ardp.201900123. Epub 2019 Aug 29.

PMID:
31463953
6.

Design, synthesis, molecular docking and biological activity evaluation of some novel indole derivatives as potent anticancer active agents and apoptosis inducers.

El-Sharief AMS, Ammar YA, Belal A, El-Sharief MAMS, Mohamed YA, Mehany ABM, Elhag Ali GAM, Ragab A.

Bioorg Chem. 2019 Apr;85:399-412. doi: 10.1016/j.bioorg.2019.01.016. Epub 2019 Jan 8.

PMID:
30665034
7.

Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking.

Selim MR, Zahran MA, Belal A, Abusaif MS, Shedid SA, Mehany ABM, Elhagali GAM, Ammar YA.

Anticancer Agents Med Chem. 2019;19(4):439-452. doi: 10.2174/1871520618666181112121058.

PMID:
30417798
8.

Design, Synthesis of New Pyridine and Pyrimidine Sugar Compounds as Antagonists Targeting the ERĪ± via Structure-Based Virtual Screening.

Nassar IF, El-Sayed WA, Ragab TIM, Shalaby ASG, Mehany ABM.

Mini Rev Med Chem. 2019;19(5):395-409. doi: 10.2174/1389557518666180820125210.

PMID:
30124151
9.

Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents.

Fayed EA, Eissa SI, Bayoumi AH, Gohar NA, Mehany ABM, Ammar YA.

Mol Divers. 2019 Feb;23(1):165-181. doi: 10.1007/s11030-018-9865-9. Epub 2018 Aug 11.

PMID:
30099687
10.

Design, synthesis, antiproliferative activity, molecular docking and cell cycle analysis of some novel (morpholinosulfonyl) isatins with potential EGFR inhibitory activity.

Ammar YA, Sh El-Sharief AM, Belal A, Abbas SY, Mohamed YA, Mehany ABM, Ragab A.

Eur J Med Chem. 2018 Aug 5;156:918-932. doi: 10.1016/j.ejmech.2018.06.061. Epub 2018 Jun 28.

PMID:
30096580
11.

Design, synthesis and anticancer evaluation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers.

Gaber AA, Bayoumi AH, El-Morsy AM, Sherbiny FF, Mehany ABM, Eissa IH.

Bioorg Chem. 2018 Oct;80:375-395. doi: 10.1016/j.bioorg.2018.06.017. Epub 2018 Jun 12.

PMID:
29986185
12.

Design, synthesis, biological evaluations, molecular docking, and in vivo studies of novel phthalimide analogs.

Zahran MAH, El-Aarag B, Mehany ABM, Belal A, Younes AS.

Arch Pharm (Weinheim). 2018 May;351(5):e1700363. doi: 10.1002/ardp.201700363. Epub 2018 Apr 3.

PMID:
29611624
13.

Alpha lipoic acid protects against chlorpyrifos-induced toxicity in Wistar rats via modulating the apoptotic pathway.

Mohamed WR, Mehany ABM, Hussein RM.

Environ Toxicol Pharmacol. 2018 Apr;59:17-23. doi: 10.1016/j.etap.2018.02.007. Epub 2018 Feb 23.

PMID:
29500983
14.

Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3,6-dimethyl-1-phenyl-4-(substituted-methoxy)pyrazolo[3,4-d] pyrimidine Derivatives.

Bakr RB, Mehany ABM, Abdellatif KRA.

Anticancer Agents Med Chem. 2017;17(10):1389-1400. doi: 10.2174/1872211311666170213105004.

PMID:
28270084

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