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Polymers (Basel). 2019 Apr 17;11(4). pii: E705. doi: 10.3390/polym11040705.

Engineered Electrospun Polyurethane Composite Patch Combined with Bi-functional Components Rendering High Strength for Cardiac Tissue Engineering.

Author information

1
School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia. mohanprasathutm@gmail.com.
2
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 71000, Vietnam. saravana@tdtu.edu.vn.
3
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 71000, Vietnam. saravana@tdtu.edu.vn.
4
IJNUTM Cardiovascular Engineering center, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia. saravana@tdtu.edu.vn.
5
Centre for Artificial Intelligence and Robotics, Universiti Teknologi Malaysia, Kuala Lumpur 54100, Malaysia. athif@utm.my.
6
School of Electrical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia. athif@utm.my.
7
Media and Game Innovation Centre of Excellence (MaGICX), Institute of Human Centered Engineering (iHumEn), Universiti Teknologi Malaysia, Skudai 81310, Malaysia. shahrizal@utm.my.
8
School of Computing, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia. shahrizal@utm.my.

Abstract

Cardiovascular application of nanomaterial's is of increasing demand and its usage is limited by its mechanical and blood compatible properties. In this work, an attempt is made to develop an electrospun novel nanocomposite loaded with basil oil and titanium dioxide (TiO2) particles. The composite material displayed increase in hydrophobic and reduced fiber diameter compared to the pristine polymer. Fourier transform infrared spectroscopy results showed the interaction of the pristine polymer with the added substances. Thermal analysis showed the increased onset degradation, whereas the mechanical testing portrayed the increased tensile strength of the composites. Finally, the composite delayed the coagulation times and also rendered safe environment for red blood cells signifying its suitability to be used in contact with blood. Strikingly, the cellular toxicity of the developed composite was lower than the pristine polymer suggesting its compatible nature with the surrounding tissues. With these promising characteristics, developed material with enhanced physicochemical properties and blood compatibility can be successfully utilized for cardiac tissue applications.

KEYWORDS:

basil/titanium dioxide; biocompatibility; cardiac tissue applications; physico-chemical properties; polyurethane

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