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J Diabetes Res. 2019 Aug 14;2019:8562408. doi: 10.1155/2019/8562408. eCollection 2019.

Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology.

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Institute of Clinical and Experimental Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara, Mexico.
Department of Ophthalmology, Specialties Hospital of the National Occidental Medical Center, Mexican Institute of Social Security, Mexico.
Tecnológico de Monterrey Institute, School of Medicine and Health Sciences, Campus Guadalajara, Mexico.
Department of Physiology, University Center of Tonalá, University of Guadalajara, Mexico.


Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM) causing vision impairment even at young ages. There are numerous mechanisms involved in its development such as inflammation and cellular degeneration leading to endothelial and neural damage. These mechanisms are interlinked thus worsening the diabetic retinopathy outcome. In this review, we propose oxidative stress as the focus point of this complication onset.

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Authors declare that they have no conflicts of interest to report.

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