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J Hum Lact. 2017 Feb;33(1):181-187. doi: 10.1177/0890334416680176. Epub 2017 Jan 20.

Enhancing Human Milk Production With Domperidone in Mothers of Preterm Infants.

Author information

1
Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
2
Izaak Walton Killam Health Centre, Dalhousie University, Halifax, NS, Canada.
3
Perinatal and Women's Health, London Health Sciences Centre, Western University, London, ON, Canada.
4
Division of Clinical Pharmacology & Toxicology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
5
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
6
School of Pharmacy, University of Waterloo, Kitchener, ON, Canada.
7
Christoph Fusch; Lajos Kovacs; Annie Janvier; Georges Cauoette; Abhay Lodha; Barbara Bulleid; Doug McMillan; Balpreet Singh

Abstract

BACKGROUND:

Mothers of preterm infants often are at risk of expressing an inadequate amount of milk for their infants and the use of galactogogues is often considered. Domperidone is a widely used galactogogue with little information available to guide clinicians regarding initiation, timing, and duration of treatment. Research aim: The primary objective of this study was to determine whether administration of domperidone within the first 21 days after delivery would lead to a higher proportion of mothers achieving a 50% increase in the volume of milk at the end of 14 days of treatment compared with mothers receiving placebo.

METHODS:

Eligible mothers were randomized to one of two treatment arms: Group A-domperidone 10 mg orally three times daily for 28 days; or Group B-placebo 10 mg orally three times daily for 14 days followed by domperidone 10 mg orally three times daily for 14 days.

RESULTS:

A total of 90 mothers of infants ≤ 29 weeks gestation were randomized. Mean milk volumes at entry were similar for both groups. More mothers achieved a 50% increase in milk volume after 14 days in Group A (77.8%) compared with Group B (57.8%), odds ratio = 2.56, 95% confidence interval [1.02, 6.25], p = .04.

CONCLUSION:

A greater number of mothers experienced a 50% or more increase in human milk volume, but the absolute increase in milk volume was modest.

KEYWORDS:

breast milk expression; breastfeeding; galactogogues; human milk; human milk production; lactation difficulties; milk supply; randomized controlled trials

PMID:
28107101
DOI:
10.1177/0890334416680176
[Indexed for MEDLINE]

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