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Medicina (Kaunas). 2018 Dec 3;54(6). pii: E99. doi: 10.3390/medicina54060099.

Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies.

Author information

1
Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran. mozaffari20@yahoo.com.
2
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran. mozaffari20@yahoo.com.
3
Dermatology Unit, Department of Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", 28100 Novara, Italy. elisa.zavattaro@med.uniupo.it.
4
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran. abbas_a@icloud.com.
5
Facultad de Medicina y Odontologia Universidad de Murcia, Hospital Morales Meseguer, Clinica Odontologic Adv Marques Velez s/n, 30008 Murcia, Spain. majornet@um.es.
6
Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran. n.omidpanah@yahoo.com.
7
Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran. roholahsharifi@gmail.com.
8
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran. sadeghi_mbrc@yahoo.com.
9
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran. sadeghi_mbrc@yahoo.com.
10
Department of Oral Medicine, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran. dsshoriabii@yahoo.com.
11
Oral and Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran. mohsen_safaei@yahoo.com.

Abstract

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastleā»Ottawa Quality Assessment Scale (NOS) questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Out of 70 studies found in the databases, 8 studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of IgA, IgG, and IgM were -0.13 g/L [95% CI: -0.24, -0.02; P = 0.02], 1.01 g/L [95% CI: -0.91, 2.93; P = 0.30], and -0.06 g/L [95% CI: -0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95% CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95% CI: -0.20, 1.38; P = 0.14], respectively. Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had higher values than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

KEYWORDS:

immunoglobulin; oral lichen planus; saliva; serum

PMID:
30513983
PMCID:
PMC6306895
DOI:
10.3390/medicina54060099
[Indexed for MEDLINE]
Free PMC Article

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