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Items: 1 to 20 of 177

1.

Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase.

Channar PA, Irum H, Mahmood A, Shabir G, Zaib S, Saeed A, Ashraf Z, Larik FA, Lecka J, Sévigny J, Iqbal J.

Bioorg Chem. 2019 Jul 23;91:103137. doi: 10.1016/j.bioorg.2019.103137. [Epub ahead of print]

PMID:
31400554
2.

Densely substituted piperidines as a new class of elastase inhibitors: Synthesis and molecular modeling studies.

Hamdani SS, Khan BA, Saeed A, Larik FA, Hameed S, Channar PA, Ahmad K, Mughal EU, Abbas Q, Amin NU, Ghumro SA, Maitlo H, Hassan M, Raza H, Seo SY.

Arch Pharm (Weinheim). 2019 Aug;352(8):e1900061. doi: 10.1002/ardp.201900061. Epub 2019 Jul 24.

PMID:
31338866
3.

4-Aminocoumarin based aroylthioureas as potential jack bean urease inhibitors; Synthesis, enzyme inhibitory kinetics and docking studies.

Fattah TA, Saeed A, Ashraf Z, Abbas Q, Channar PA, Larik FA, Hassan M.

Med Chem. 2019 Jul 15. doi: 10.2174/1573406415666190715164834. [Epub ahead of print]

PMID:
31309895
4.

Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities.

Zahra MH, Salem TAR, El-Aarag B, Yosri N, El-Ghlban S, Zaki K, Marei AH, Abd El-Wahed A, Saeed A, Khatib A, AlAjmi MF, Shathili AM, Xiao J, Khalifa SAM, El-Seedi HR.

Molecules. 2019 Jul 8;24(13). pii: E2495. doi: 10.3390/molecules24132495.

5.

Investigation of potent inhibitors of cholinesterase based on thiourea and pyrazoline derivatives: Synthesis, inhibition assay and molecular modeling studies.

Mumtaz A, Majeed A, Zaib S, Ur Rahman S, Hameed S, Saeed A, Rafique H, Mughal E, Maalik A, Hussain I, Iqbal J.

Bioorg Chem. 2019 Sep;90:103036. doi: 10.1016/j.bioorg.2019.103036. Epub 2019 Jun 4.

PMID:
31271943
6.

Anti-proliferative Effects of Chromones: Potent Derivatives Affecting Cell Growth and Apoptosis in Breast, Bone-marrow and Cervical Cancer Cells.

Iqbal J, Ejaz SA, Miliutina M, Langer P, Saeed A.

Med Chem. 2019 Jun 21. doi: 10.2174/1573406415666190621155843. [Epub ahead of print]

PMID:
31223093
7.

Synthesis, molecular docking and kinetic studies of novel quinolinyl based acyl thioureas as mushroom tyrosinase inhibitors and free radical scavengers.

Mustafa MN, Saeed A, Channar PA, Larik FA, Zain-Ul Abideen M, Shabir G, Abbas Q, Hassan M, Raza H, Seo SY.

Bioorg Chem. 2019 Sep;90:103063. doi: 10.1016/j.bioorg.2019.103063. Epub 2019 Jun 12.

PMID:
31220666
8.

Synthesis and characterization of DGEBA composites reinforced with Cu/Ag modified carbon nanotubes.

Iqbal A, Saeed A, Kausar A, Arshad M, Mahar J.

Heliyon. 2019 May 29;5(5):e01733. doi: 10.1016/j.heliyon.2019.e01733. eCollection 2019 May.

9.

Plants mentioned in the Islamic Scriptures (Holy Qur'ân and Ahadith): Traditional uses and medicinal importance in contemporary times.

El-Seedi HR, Khalifa SAM, Yosri N, Khatib A, Chen L, Saeed A, Efferth T, Verpoorte R.

J Ethnopharmacol. 2019 Oct 28;243:112007. doi: 10.1016/j.jep.2019.112007. Epub 2019 Jun 4. Review.

PMID:
31170516
10.

Recent developments and comparison of transformation strategies for organic halides to aldehydes and ketones.

Faisal M, Saeed A, Shahzad D, Dar P, Larik FA.

Mol Divers. 2019 May 16. doi: 10.1007/s11030-019-09956-1. [Epub ahead of print] Review.

PMID:
31098859
11.

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics.

Shahzad D, Saeed A, Larik FA, Channar PA, Abbas Q, Alajmi MF, Arshad MI, Erben MF, Hassan M, Raza H, Seo SY, El-Seedi HR.

Molecules. 2019 Apr 17;24(8). pii: E1511. doi: 10.3390/molecules24081511.

12.

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT, and DNA-Binding Studies of (E)-2-(3-Hydroxy-4-Methoxybenzylidene)Hydrazinecarbothioamide.

Channar PA, Arshad N, Farooqi SI, Larik FA, Saeed A, Hökelek T, Shehzadi SA, Abbas N, Flörke U.

Appl Biochem Biotechnol. 2019 Sep;189(1):175-192. doi: 10.1007/s12010-019-03008-y. Epub 2019 Apr 10.

PMID:
30972703
13.

Aroylthiourea derivatives of ciprofloxacin drug as DNA binder: Theoretical, spectroscopic and electrochemical studies along with cytotoxicity assessment.

Farooqi SI, Arshad N, Perveen F, Channar PA, Saeed A, Javeed A.

Arch Biochem Biophys. 2019 May 15;666:83-98. doi: 10.1016/j.abb.2019.03.021. Epub 2019 Apr 2.

PMID:
30951683
14.

Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies.

Hayat K, Afzal S, Saeed A, Murtaza A, Ur Rahman S, Khan KM, Saeed A, Zaib S, Lecka J, Sévigny J, Iqbal J, Hassan A.

Bioorg Chem. 2019 Jun;87:218-226. doi: 10.1016/j.bioorg.2019.03.019. Epub 2019 Mar 12.

PMID:
30903944
15.

Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5'-nucleotidase inhibitors.

Hassan S, Channar PA, Larik FA, Saeed A, Shah HS, Lecka J, Sévigny J, Iqbal J.

R Soc Open Sci. 2018 Sep 12;5(9):180837. doi: 10.1098/rsos.180837. eCollection 2018 Sep.

16.

Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation.

Ujan R, Saeed A, Channar PA, Larik FA, Abbas Q, Alajmi MF, El-Seedi HR, Rind MA, Hassan M, Raza H, Seo SY.

Molecules. 2019 Feb 28;24(5). pii: E860. doi: 10.3390/molecules24050860.

17.

Synthesis of sulfonamide, amide and amine hybrid pharmacophore, an entry of new class of carbonic anhydrase II inhibitors and evaluation of chemo-informatics and binding analysis.

Ahmed A, Channar PA, Saeed A, Kalesse M, Kazi MA, Larik FA, Abbas Q, Hassan M, Raza H, Seo SY.

Bioorg Chem. 2019 May;86:624-630. doi: 10.1016/j.bioorg.2019.01.060. Epub 2019 Feb 10.

PMID:
30807935
18.

Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies.

Larik FA, Faisal M, Saeed A, Channar PA, Korabecny J, Jabeen F, Mahar IA, Kazi MA, Abbas Q, Murtaza G, Khan GS, Hassan M, Seo SY.

Bioorg Chem. 2019 May;86:473-481. doi: 10.1016/j.bioorg.2019.02.011. Epub 2019 Feb 8.

PMID:
30772648
19.

One-pot four-component synthesis of thiazolidin-2-imines using CuI/ZnII dual catalysis: A new class of acetylcholinesterase inhibitors.

Shehzadi SA, Khan I, Saeed A, Larik FA, Channar PA, Hassan M, Raza H, Abbas Q, Seo SY.

Bioorg Chem. 2019 Mar;84:518-528. doi: 10.1016/j.bioorg.2018.12.002. Epub 2018 Dec 5.

PMID:
30610971
20.

Cardenolides: Insights from chemical structure and pharmacological utility.

El-Seedi HR, Khalifa SAM, Taher EA, Farag MA, Saeed A, Gamal M, Hegazy MF, Youssef D, Musharraf SG, Alajlani MM, Xiao J, Efferth T.

Pharmacol Res. 2019 Mar;141:123-175. doi: 10.1016/j.phrs.2018.12.015. Epub 2018 Dec 21. Review.

PMID:
30579976

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